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| Number | Title | Issue Date |
| 8084239 | Preparation of a therapeutic composition Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system comprises a unique peptide having 31 amino acids and another unique peptide having 21 amino acids and connected with an oligo-nucleotide through a diphosphodie... | 12/27/2011 |
| 7524661 | Preparation of a therapeutic composition Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system, comprises a unique peptide having 31 amino acids and another unique peptide having 21 amino acids and connected with an oligo-nucleotide through a diphosphodi... | 04/28/2009 |
| 7432074 | Method for extracting a macrolide from biomatter Provided is a method for obtaining a macrolide, especially tacrolimus, from biomatter. ... | 10/07/2008 |
| 7166452 | Aminoketone asymmetric reductase and nucleic acid thereof A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on 1-2-methylaminopropiophenone, and having the following physiochemical properties: substrate: 1-2-methylaminopropi... | 01/23/2007 |
| 7144715 | Production of α-keto butyrate A process of obtaining α-keto butyrate by bioconversion is disclosed. The molecule is accumulated in the medium and is apt to subsequent processing to food ingredients, such as top-note flavors. A suitable strain is a natural ilv-3 mutant Neurospora crassa s... | 12/05/2006 |
| 7115412 | Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthes... | 10/03/2006 |
| 6972191 | Method for production of geranylgeraniol and analogous compounds thereof by microorganisms The present invention provides a method for producing geranylgeraniol and analogous compounds thereof, which comprises culturing yeast cells (ascomycetes and deuteromycetes), bacterial cells, actinomycete cells or filamentous fungus cells, all of which are capable o... | 12/06/2005 |
| 6936731 | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high p... | 08/30/2005 |
| 6867023 | Production method of polyhydroxyalkanoate from substituted fatty acid ester as raw material Polyhydroxyalkanoates comprising a monomer unit having the following chemical formula (2): (where the reference characters R represents an arbitrarily selected substituent and x represents an integer of 0 to 8) is prod... | 03/15/2005 |
| 6835559 | Process for the production of optically active β-amino alcohols A process for producing an optical active β-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of ... | 12/28/2004 |
| 6699695 | Rhodococcus microorganisms and process for producing amide compounds A nitrile compound having a complicated structure (e.g., 2-hydroxy-4-methylthiobutyronitrile) is converted into an amide compound with high production efficiency, by using a novel microorganism of which the gene 16S rRNA has a specific base sequence. As t... | 03/02/2004 |
| 6586393 | Antibiotics GE 23077, pharmaceutically acceptable salts and compositions, and use thereof The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any proportion, the pharmaceutically acceptable salts and compositio... | 07/01/2003 |
| 6444448 | Production of ଲ-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions There is provided a method of production of an immunostimulatory ଲ-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35 to 60° C. for 6 to 48 hours, and separating solid m... | 09/03/2002 |
| 6365383 | Method of producing erythritol by repeated fed-batch fermentation The invention relates to a method of producing erythritol by fed-batch and repeated fermentation of sugars by microorganisms which produce erythritol, characterised by the fact that the fermentation is started by introducing said microorganisms into a fer... | 04/02/2002 |
| 6306629 | Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to prav... | 10/23/2001 |
| 6300327 | Compositions and methods for potentiation of neurotrophin activity Compositions and methods for use in modulating neurotrophin activity, wherein the active agent is at least one compound which potentiates neurotrophin activity. A preferred class of active agents is K-252 compounds, including both microbial metabolites an... | 10/09/2001 |
| 6277602 | Method of producing 1-menthyl- -D-glucopyranoside A method of producing 1-menthyl--D-glucopyranoside is provided, wherein microorganisms capable of producing 1-menthol glycoside from 1-menthol are added to sugars and 1-menthol. Bacteria selected from the group consisting of Xanthomonas species, St... | 08/21/2001 |
| 6193964 | Strain of streptomyces, and relevant uses thereof Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.... | 02/27/2001 |
| 6183972 | Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect Disclosed is a method for determining the concentration of an analyte in a fluid test medium by use of an immunochromatographic test strip through which the test fluid can flow by capillarity. The test strip has at least two capture bands and optionally o... | 02/06/2001 |
| 5962286 | Process for the production of gluconic acid with a strain of Aureobasidium pullulans (de bary) Arnaud Strains of Aureobasidium pullulans (de bary) Arnaud can be used for the commercial production of gluconic acid by fermentation in aqueous liquid containing sugar, which in continuous culture from glucose form greater than or equal to 90% and greater than ... | 10/05/1999 |
| 5925550 | Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex The present invention relates to a method for selectively enhancing the production of factors A2 and/or A3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, ... | 07/20/1999 |
| 5843437 | A82846 antibiotics New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancom... | 12/01/1998 |
| 5843679 | Method for selectively enhancing the production of factors A or B0 of antibiotic A 40926 complex The present invention is directed to a method for selectively enhancing the production of factors A, and/or B0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above co... | 12/01/1998 |
| 5830693 | Gene encoding a regulatory factor involved in activating expression of the nitrilase gene promoter The invention relates to a regulatory factor substantially containing an amino acid sequence represented by SEQ ID NO:1 and having the action of activating a nitrilase gene promoter, a regulatory factor gene containing DNA coding substantially for said re... | 11/03/1998 |
| 5707833 | Process of making cyclodextrin glucanotransferase with brevibacterium This invention relates to a γ-cyclodextrin glucanotransferase having novel properties, to a process for the production of the γ-cyclodextrin glucanotransferase which comprises culturing a strain belonging to the genus Brevibacterium capable of producing... | 01/13/1998 |
| 5627057 | Inhibitor compounds of farnesyl-protein transferase and chemotherapeutic compositions containing the same, produced by strain ATCC 55532 The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 05/06/1997 |
| 5573946 | Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invent... | 11/12/1996 |
| 5494812 | Suidatrestin and production thereof A novel trehalase inhibitor having the following physicochemical properties: (1) Activity: a specific inhibitory activity to trehalase; (2) Form: white powder, water-soluble; (3) Somogy-Nelson test: negative (4) Rydon-Smith test: positive (5) Optical rotation [�... | 02/27/1996 |
| 5378463 | Antitumor antibiotic A certain fermentation product of Actinomadura strain Q473-8 yield, when suitably treated, a novel compound having both antibiotic and antitumor activities.... | 01/03/1995 |
| 5372816 | Trehalostatin and process for the preparation thereof This invention relates to the substance Trehalostatin which is a white powder soluble in water but hardly or only slightly soluble in hexane, benzene, ethers and petroleum ether, shows no absorption maxima at 220 nm or above in its ultraviolet visible lig... | 12/13/1994 |
| 5354685 | Suidatrestin and production thereof A novel trehalase inhibitor having the following physicochemical properties: (1) Activity: a specific inhibitory activity to trehalase; (2) Form: white powder, water-soluble; (3) Somogy-Nelson test: negative (4) Rydon-Smith test: positive (5) Optical rotation [�... | 10/11/1994 |
| 5332574 | Compounds produced by a strain of Streptomyces exfoliatus Disclosed are active compounds BU-4726G-A and BU-4726G-B which contain a quinone chromophore and hydroquinone chromophore, respectively. The compounds are produced by fermentation of Streptomyces exfoliatus AA4510. The compounds possess antimicrobial, and... | 07/26/1994 |
| 5332837 | CC-1065 analogs This invention concerns 2-acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula I': ##STR1## the compounds of Formula I' are useful as uv light absorber substances, as chemical intermediates and as prodrugs of k... | 07/26/1994 |
| 5320946 | Method and element for assay of catechol and catechol generating substances A method and multilayer analytical element for the determination of catechol and catechol generating substances such as salicylate is described. A series of enzymatic conversions involving tyrosinase is used to convert catechol to o-quinone and the latter... | 06/14/1994 |
| 5304373 | Antitumor antibiotic A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.... | 04/19/1994 |
| 5290772 | Immunosuppressant agent Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism, Actinoplanacete sp, (Merck Culture Collection MA 6559) ATCC No. ... | 03/01/1994 |
| 5286649 | Antiviral antibiotic BU-3889V Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A2, A3, D1, D2 and D3, by fermentation of a BU-3889V producing strain of the new microorganism Amyco... | 02/15/1994 |
| 5281417 | Antitumor process employing novel fermentate of an Actinomadura strain A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.... | 01/25/1994 |
| 5275817 | Physiologically active kanglemycin C Novel physiologically active substance, kanglemycin C, having a molecular weight of 326 and is isolated from the fermentation broth of Nocardia mediterranei var. kanulensis 1747-64 which belongs to the genus Nocardia. Kanglemycin C has an immunosuppressiv... | 01/04/1994 |
| 5244790 | Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same The present invention relates to microorgaisms which produce the aroma and flavor of traditional Korean soybean paste. The present invention also relates to a method for producing the soybean paste which comprises inoculating a pure boiled soybean medium ... | 09/14/1993 |
