Quotables
"The production of too many useful things results in too many useless people."
Karl Marx
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183006 | Screening method for identifying new aminoacyl-tRNA synthetase inhibitors The method comprising: a) obtaining a gene sequence codifying a naturally occurring aminoacyl-tRNA synthetase; b) engineering the gene codifying for said aminoacyl-tRNA synthetase, resulting into an aminoacyl-tRNA synthetase with a defective activity, with the provi... | 05/22/2012 |
| 8183007 | ADP detection based methods using adenylate cyclase and bioluminescence The disclosure provides compositions and methods to determine or detect ADP or the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP hydrolases such as ATPases, e.g., HSP90, that employ ATP as a subs... | 05/22/2012 |
| 8183005 | Pharmaceutical agents for treating HCV infections The present inventors examined the inhibitory activity against HCV replicon of myriocin, fumonisin B1, and ceramide trafficking inhibitor HPA-12, which are compounds derived from microorganisms such as those of the genus Aureobasidium, and found that these co... | 05/22/2012 |
| 8178314 | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein The invention relates to pyrimidines suitable as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido;... | 05/15/2012 |
| 8158376 | Bisubstrate fluorescent probe binding to protein kinases This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstr... | 04/17/2012 |
| 8153389 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K The present invention relates to methods for the identification of a PI3K interacting compound using phenylthiazole ligand 1. ... | 04/10/2012 |
| 8153390 | FRET-based binding assay The present invention provides for an assay that identifies kinase inhibitors by employing fluorescence resonance energy transfer in a competition binding approach. ... | 04/10/2012 |
| 8124368 | Fluorogenic protein kinase substrates The present invention relates to kinase sensors comprising a metal chelator and a fluorophore, where the chelator comprises a quinoline group and where the fluorophore is conjugated to the chelator. The invention also relates to methods of using these kinase sensors... | 02/28/2012 |
| 8105799 | Methods of screening compounds inhibiting signal transduction through inflammatory cytokines Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflamm... | 01/31/2012 |
| 8101375 | Compositions and methods for detecting phosphomonoester The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a f... | 01/24/2012 |
| 8097432 | Method for diagnosing hemangiosarcoma in canine using detection of thymidine kinase activity The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contactin... | 01/17/2012 |
| 8076098 | Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclo... | 12/13/2011 |
| 8003342 | Method for identifying farnesyl transferase inhibitors Disclosed are methods and compositions for the identification of inhibitors of farnesyl protein transferases, enzymes involved in the farnesylation of various cellular proteins, including cancer related ras proteins such as p21ras. One farnesyl protein tr... | 08/23/2011 |
| 7981633 | Method for measuring tyrosine kinase phosphorylation The present invention relates to methods for measuring the autophosphorylation of one or more tyrosine kinases and use of such methods in profiling kinase inhibitors and activators. As a representative example, the method comprises inducing kinase autophosphorylatio... | 07/19/2011 |
| 7972805 | Phytase-containing animal food and method A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff... | 07/05/2011 |
| 7968309 | Method for improving the thermostability of sucrose phosphorylase (SP) A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having improved thermostability has an amino acid residue which is different from t... | 06/28/2011 |
| 7964373 | Transformed cell with enhanced sensitivity to antifungal compound and use thereof The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at ... | 06/21/2011 |
| 7960134 | Kinase inhibition models and their uses The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases. ... | 06/14/2011 |
| 7960133 | Methods of diagnosing leiomyoma by measuring catechol-O-methyltransferase The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and c... | 06/14/2011 |
| 7955814 | Method A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuf... | 06/07/2011 |
| 7955813 | Method of using lipid acyltransferase A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuf... | 06/07/2011 |
| 7947468 | Methods A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radi... | 05/24/2011 |
| 7932049 | Methods of identifying longevity modulators and therapeutic methods of use thereof The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended li... | 04/26/2011 |
| 7923218 | Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction ... | 04/12/2011 |
| 7901901 | Assays for measuring phosphate modification enzyme activity The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays can also be used to identify and screen for substances that modulate th... | 03/08/2011 |
| 7892776 | Screening assay to identify modulators of protein kinase A Methods for screening compounds for their activity as a protein kinase A modulators are provided. The methods are based on fluorescence polarization of peptide probes to identify drug candidates that act by activating or inhibiting the catalytic function of PKA. In ... | 02/22/2011 |
| 7888058 | Transformed cell with enhanced sensitivity to antifungal compound and use thereof The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at ... | 02/15/2011 |
| 7858333 | Method for screening candidate compounds for antitumor drug Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD... | 12/28/2010 |
| 7851175 | Kit for assaying acetyl transferase or deacetylase activity The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non... | 12/14/2010 |
| 7846683 | Method for identifying agents which modulate cell growth or survival The present invention relates to a method for identifying an agent. for modulating cell growth or survival. The method involves the identification of an agent which modulates the net ratio of nuclear-localized versus cytosolic-localized H11 kinase or mutant H11 kina... | 12/07/2010 |
| 7833743 | Phytase-containing animal food and method A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff... | 11/16/2010 |
| 7820403 | ACTR-1, a novel human acyltransferase and uses thereof The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nuclei... | 10/26/2010 |
| 7811781 | Core 2 β(1,6)-acetylglycosaminyltransferase as diagnostic marker for atherosclerosis A method of indicating the presence of the atherosclerosis (particularly coronary artery atherosclerosis) in a subject is provided, comprising comparing the level of Core 2 GlcNAc-T in a tissue sample from a subject with a reference level determined for the same tis... | 10/12/2010 |
| 7807398 | Method of using lipid acyltransferase A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuf... | 10/05/2010 |
| 7803571 | Method for identifying IRS inhibitors or agonists The present invention relates to a method for the identification of an IRS protein kinase inhibitor, comprising the steps of a) bringing into contact PKC-ζ with at least one IRS peptide comprising at least one PKC-ζ-Ser-phosphorylation site in the presence of at l... | 09/28/2010 |
| 7794964 | Biochip for the detection of phosphorylation and the detection method using the same The present invention relates to a biochip for detecting phosphorylation and a method for detecting phosphorylation using the same, more precisely a biochip prepared by integrating a protein produced from the recombination of a substrate of kinase selected from the ... | 09/14/2010 |
| 7785821 | Measurement of nicotinamde N-methyl transferase in diagnosis of lung cancer The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Mea... | 08/31/2010 |
| 7767411 | Assay system for specific inhibitors of protein kinase C-related kinases The present invention relates to an assay system for specific inhibitors of protein kinase C-related kinases (PRKs) relating to one or more of the reactions wherein said protein kinase C-related kinases are involved under physiological conditions. The invention also... | 08/03/2010 |
| 7759084 | Transformed cell with enhanced sensitivity to antifungal compound and use thereof The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at ... | 07/20/2010 |
| 7745164 | Methods of modulating apoptosis using inhibitors of brain-localized protein kinases homologous to homeodomain-interacting protein kinases The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods ... | 06/29/2010 |
