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| Number | Title | Issue Date |
| 7846701 | Method for preparing optically active compound According to the present invention, there is provided a method for preparing an optically active compound, characterized in that said method comprises permitting a mixture of optical isomers relative to the carbon atom in the β-position in relation to the carbon at... | 12/07/2010 |
| 7771977 | Alkane polyol dehydrogenase Disclosed is a protein selected from: (1) a protein comprising the amino acid sequence of SEQ ID NO: 1 in the Sequence Listing; (2) a protein comprising the amino acid sequence of SEQ ID NO: 1 in the Sequence Listing with the deletion, addi... | 08/10/2010 |
| 7592166 | Enone reductase gene and microbial production of levodione Disclosed is an isolated DNA comprising a nucleotide sequence coding for an enzyme having enone reductase activity wherein the enzyme is characterized by the following physico-chemical properties: (a) molecular mass: 61,300±5,000 Da (estimated using gel filtration,... | 09/22/2009 |
| 7364884 | Method for producing a hydroxylation catalyst and the use thereof A process for preparing a hydroxylation catalyst by i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel matrix, and combini... | 04/29/2008 |
| 7348167 | Increase in the vitamin E content in organisms due to an increase in the tyrosine aminotransferase activity The present invention relates to a process for producing vitamin E by growing organisms, in particular plants, which have an increased tyrosine aminotransferase activity in comparison with the wild type, and to the genetically modified organisms, in particular plant... | 03/25/2008 |
| 7291486 | Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii | 11/06/2007 |
| 7259295 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 08/21/2007 |
| 7256023 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 08/14/2007 |
| 7256022 | Pufa polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 08/14/2007 |
| 7252985 | Carotenoid ketolases Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW ketolases previously reported. Expression of the carotenoid ketolases in ... | 08/07/2007 |
| 7247461 | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from Schizochytrium sp., to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding ... | 07/24/2007 |
| 7217856 | PUFA polyketide synthase systems and uses thereof Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, t... | 05/15/2007 |
| 7214853 | Schizochytrium PKS genes The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required fo... | 05/08/2007 |
| 7211418 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 05/01/2007 |
| 7172894 | Reductase gene and use of the same A gene containing a DNA having the nucleotide sequence encoding any one of the amino acid sequences of the following (a) to (e): (a) an amino acid sequence set out in SEQ ID NO: 1; (b) an amino acid sequence having... | 02/06/2007 |
| 7157268 | Process for producing L-epi-2-inosose and novel process for producing epi-inositol using microorganisms Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, inexpensive myo-inositol is used as a starting compo... | 01/02/2007 |
| 7148063 | Mitochondrial creatine kinase antibody The object of the present invention is to provide a method for more accurately assaying the enzyme activities of mCK isozymes and a method for separately assaying the enzyme activities of CK isozymes by separately assaying the enzyme activities of ubiquitous mCK (um... | 12/12/2006 |
| 7148045 | Hybrid polyketide synthases and novel loading domains A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further k... | 12/12/2006 |
| 7129071 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 10/31/2006 |
| 7122703 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 10/17/2006 |
| 7109043 | Fluorescent probe for magnesium ion determination A fluorescent probe for measuring magnesium ion, which can selectively form a complex with magnesium ion in aqueous system is disclosed. The fluorescent probe for measuring magnesium ion according to the present invention has the structure represented by the followi... | 09/19/2006 |
| 7101684 | Modified modular polyketide synthase Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides. ... | 09/05/2006 |
| 7098189 | Wound and skin care compositions The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-relate... | 08/29/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7067286 | host cells containing heterologous PKS genes for the synthesis of polykedtides Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided. ... | 06/27/2006 |
| 7063969 | Yeast-based process for production of l-pac The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either ... | 06/20/2006 |
| 7056540 | Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root The present invention relates to an enzymatic process for the preparation of optically active chiral alcohols using tuberous root Daucus carota; particularly invention relates to an enzymatic process for the preparation of optically active alcohols by enantio... | 06/06/2006 |
| 7049100 | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of no... | 05/23/2006 |
| 7049111 | Process for producing HMG-CoA reductase inhibitor The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 ... | 05/23/2006 |
| 7045554 | Method for improved Fischer-Tropsch catalyst stability and higher stable syngas conversion The present invention is generally related towards methods for preparing and using a more stable synthesis catalysts. In particular, the present invention is directed towards treating synthesis catalysts with low levels of oxygen to deactivate the smaller more unsta... | 05/16/2006 |
| 7033818 | Recombinant polyketide synthase genes Regions of sequence identity are recurrent in some modular polyketide synthase (PKS) gene clusters. Such sequences are potentially detrimental to the stability of PKS gene clusters and expression plasmids for the genes in the gene cluster. PKS gene and gene cluster ... | 04/25/2006 |
| 7025985 | Dihydroxyphenyl compounds and glucoside compounds thereof The present invention is a compound represented by the following formula (1) or (2): where one of R1 and R2 is hydrogen and the other one is hydrogen or glucose residue. The compound is effective f... | 04/11/2006 |
| 7015001 | DNA encoding SPNF of the spinosyn cluster Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes... | 03/21/2006 |
| 7011959 | Heterologous production of polyketides Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimer... | 03/14/2006 |
| 7001748 | Methods of making polyketides using hybrid polyketide synthases Linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides... | 02/21/2006 |
| 6998258 | L-pantolactone-hydrolase and a method for producing D-pantolactone The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a... | 02/14/2006 |
| 6992112 | Selective removal of oxygen from syngas The present invention is an improvement in the preparation of liquid hydrocarbons from natural gas/methane, oxygen and/or steam. In particular, the present invention relates to processes for the production of synthesis gas, reducing the oxygen concentration from the... | 01/31/2006 |
| 6969584 | Combinatorial enzymatic complexes The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity. ... | 11/29/2005 |
| 6969611 | Methods to prepare cells comprising heterologous polyketide synthase expression systems Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the ... | 11/29/2005 |
| 6939691 | and host cells that contain MatBC genes or host cells that contain pcc genes useful for enhanced polyketide production The use of enzymes that catalyze the production of starter and extender units for polyketides in E. coli and Streptomyces is described; these enzymes include malonyl CoA decarboxylase (MatA), malonyl CoA synthetase (MatB), and a malonate transporter (M... | 09/06/2005 |
