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| Number | Title | Issue Date |
| 8158395 | Polypeptides having C4 dicarboxylic acid transporter activity and polynucleotides encoding same The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleoti... | 04/17/2012 |
| 8143036 | Genetically modified microorganisms for producing itaconic acid with high yields Genetically modified microorganisms that produce itaconic acid at high yields and uses thereof. ... | 03/27/2012 |
| 8129154 | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enz... | 03/06/2012 |
| 8119377 | Recombinant microorganisms for increased production of organic acids Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombi... | 02/21/2012 |
| 8076111 | Method for producing an organic acid An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction ... | 12/13/2011 |
| 8021864 | Biomass-resource-derived polyester and production process thereof The present invention provides a resin capable of contributing greatly to solve environmental problems and problems related to exhaustion of fossil fuel resources and having physical properties suited for practical use. The polyester according to the present ... | 09/20/2011 |
| 7993888 | Bacterium having enhanced 2-oxoglutarate dehydrogenase activity Provided is a bacterium which is capable of producing an organic acid and is modified so as to have an enhanced 2-oxoglutarate dehydrogenase activity as compared with that of an unmodified strain. An organic acid such as succinic acid can be produced by culturing th... | 08/09/2011 |
| 7985566 | Biomass-resource-derived polyester and production process thereof The present invention provides a resin capable of contributing greatly to solve environmental problems and problems related to exhaustion of fossil fuel resources and having physical properties suited for practical use. The polyester according to the present ... | 07/26/2011 |
| 7972823 | Succinic acid-producing bacterium and process for producing succinic acid Coryneform bacterium is modified so that an activity of acetyl-CoA hydrolase is decreased, and succinic acid is produced by using the bacterium. ... | 07/05/2011 |
| 7888084 | Biomass-resource-derived polyester and production process thereof The present invention provides a resin capable of contributing greatly to solve environmental problems and problems related to exhaustion of fossil fuel resources and having physical properties suited for practical use. The polyester according to the present ... | 02/15/2011 |
| 7833763 | Method for producing organic acid An object to be solved by the present invention is to provide a method for producing organic acid with higher fermentation efficiency. The present invention provides a method for producing organic acid from an organic material by allowing bacterial cell or treated p... | 11/16/2010 |
| 7829316 | Process for production of succinic acid Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product produced by any treatment of the bacterium with an organic raw material in ... | 11/09/2010 |
| 7763447 | Method of producing succinic acid with bacterium comprising a modified fumarate reductase gene or a modified succinate dehydrogenase gene Succinic acid is produced by allowing a bacterium modified to enhance fumarate reductase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to... | 07/27/2010 |
| 7563606 | Method for producing non-amino organic acid Non-amino organic acids such as succinic acid, malic acid and fumaric acid are produced by reacting bacterial cells or treated bacterial cells of a coryneform bacterium with an organic raw material in an aqueous medium containing magnesium carbonate and/or magnesium... | 07/21/2009 |
| 7435168 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 10/14/2008 |
| 7368268 | Coryneform bacterium transformant and process for producing dicarboxylic acids using the same The present invention provides an aerobic coryneform bacterium transformant in which a lactate dehydrogenase gene is disrupted, and a pyruvate carboxylase gene is recombined so as to be highly expressed by a genetic engineering method. The aerobic coryneform bacteri... | 05/06/2008 |
| 7262046 | Aerobic succinate production in bacteria Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. ... | 08/28/2007 |
| 7244610 | Aerobic succinate production in bacteria Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. ... | 07/17/2007 |
| 7183086 | Enzymatic hydrolysis of cyclic oligomers The present invention relates to a process for enzymatic hydrolysis of cyclic oligomers of poly(ethylene terephthalate), which process comprises subjecting the cyclic oligomer to the action of one or more lipolytic and/or biopolyester hydrolytic enzyme(s). ... | 02/27/2007 |
| 7163812 | shuttle vector and methods of use An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid com... | 01/16/2007 |
| 7083960 | Production of a highly active, soluble form of the cytochrome P450 reductase (CPR A) from The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal region. Also provided are host cells comprising the subject soluble ... | 08/01/2006 |
| 7063968 | Organic acid producing microorganism and process for preparing organic acids employing the same A novel microorganism capable of producing organic acids, Mannheimia sp. 55E, and a process for producing organic acid through anaerobic and aerobic incubation using the novel microorganism are provided. The method of producing an organic acid using the micro... | 06/20/2006 |
| 7022503 | Process for the stereoselective preparation of functionalized vicinal diols The present invention relates to a process for the kinetic resolution of racemic functionalized epoxides in the presence of microorganisms, crude or pure preparations thereof comprising a polypeptide having epoxide hydrolase activity. Preferred microorganisms are ye... | 04/04/2006 |
| 6933381 | Method of preparing modified cellulose ether Process for the production of polysaccharide ethers, e.g. cellulose ethers, are disclosed wherein salts formed during the process, e.g., sodium nitrate or sodium acetate, are converted to their corresponding acids and bases by means of an electric current, preferabl... | 08/23/2005 |
| 6828115 | Epoxide hydrolases from streptomyces A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting e... | 12/07/2004 |
| 6777213 | Isolation of carboxylic acids from fermentation broth A process for recovering carboxylic acids from an aqueous mixture such as a fermentation broth using a solvent containing at least one olefin without the need for first removing the spent microorganism cells is provided. A co-solvent which increases the partition co... | 08/17/2004 |
| 6743610 | Method to produce succinic acid from raw hydrolysates A method for producing succinic acid from industrial-grade hydrolysates is provided, comprising supplying an organism that contains mutations for the genes ptsG, pflB, and ldhA, allowing said organism to accumulate biomass, and allowing said organism to metabolize t... | 06/01/2004 |
| 6596521 | Method for manufacturing organic acid by high-efficiency continuous fermentation The present invention provides a method for manufacturing organic acid by high-efficiency fermentation, which comprises the steps of continuous culture of organic acid bacteria and collection of organic acid produced from the culture employing a cell-recy... | 07/22/2003 |
| 6590071 | Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use The present invention provides lipidized conjugates comprising an amino group-containing biologically active substance and a lipophilic group capable of penetrating a biological membrane. Under neutral or mildly acidic conditions, including those found in... | 07/08/2003 |
| 6548278 | Enzymatic hydrolysis of cyclic oligomers The present invention relates to a process for enzymatic hydrolysis of cyclic oligomers of poly(ethylene terephthalate), which process comprises subjecting the cyclic oligomer to the action of one or more lipolytic and/or biopolyester hydrolytic enzyme(s)... | 04/15/2003 |
| 6448061 | Pta LDHA double mutant Escherichia coli SS373 and the method of producing succinic acid therefrom This invention relates to a mutant Escherichia coli SS373 and the production of succinic acid by using the above strain. In detail, a novel E. coli SS373 (W3110 pta::Tn10 ldhA::Km) with the deficiency in the acetate and lactate forming pathways was constr... | 09/10/2002 |
| 6448025 | Motor proteins and methods for their use The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.... | 09/10/2002 |
| 6331420 | Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of produci... | 12/18/2001 |
| 6297032 | Recombinant cephalosporin C amidohydrolase in cephalosporin biosynthesis The present invention relates to an enzyme process for the one-step conversion of cephalosporin C or a derivative thereof into 7-aminocephalosporanic acid or a corresponding derivative thereof. The one step conversion is effected using a cephalosphorin C ... | 10/02/2001 |
| 6288275 | Separation and purification of carboxylic acids from fermentation broths Carboxylic acids, particularly dicarboxylic acids, are separated from a fermentation broth by adjusting the pH of the fermentation broth to about 2.0 or below, and then heating the broth to a temperature sufficient to cause formation of three immiscible p... | 09/11/2001 |
| 6265190 | Succinic acid production and purification A highly efficient process for the production and recovery of pure succinic acid from a succinate salt that involves minimal use of additional reagents, and produces virtually no waste by-products, and permits internal recycle of the base and acid values,... | 07/24/2001 |
| 6245538 | Process for recovering carboxylic acids from a fermentation broth Carboxylic acids are recovered from a fermentation broth by adjusting the pH of a fermentation broth comprised of a carboxylic acid to at least about 6.0 and then heating the pH-adjusted broth to a temperature sufficient to effect the formation of three i... | 06/12/2001 |
| 6238895 | Production of aspartic and malic acids with microbacterium The use of strains of the genus Microbacterium for the production of organic acids or amino acids by the enzymatic conversion of a fumaric acid to the organic acid or amino acid desired, as well as methods for such use and the conversion solution produced... | 05/29/2001 |
| 6184010 | Enzymatic hydrolysis of cyclic oligomers The present invention relates to a process for enzymatic hydrolysis of cyclic oligomers of poly(ethylene terephthalate), which process comprises subjecting the cyclic oligomer to the action of one or more lipolytic and/or biopolyester hydrolytic enzyme(s)... | 02/06/2001 |
| 6171831 | Method for the production of itaconic acid using aspergillus terreus solid state fermentation The method to produce itaconic acid is a solid-state fermentation method. Sugarcane pressmud or peeled sugarcane pressmud is the support used to adsorb liquid medium for the production of itaconic acid by an Aspergillus terreus mutant strain. This mutant ... | 01/09/2001 |
