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| Number | Title | Issue Date |
| 8187830 | Method for determining insulin sensitivity with biomarkers Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metaboli... | 05/29/2012 |
| 8178313 | Method for determining an analyte in a bodily fluid A method for determining (e.g., detecting and/or measuring the concentration of) an analyte in a bodily fluid sample includes obtaining a bodily fluid sample, applying the bodily fluid sample to an analyte test strip, transferring the applied bodily fluid sample to ... | 05/15/2012 |
| 8178312 | Method of estimation of blood glucose excursions in diabetic patients using 1,5-anhydroglucitol (1,5-AG) assay The invention is a method of measuring blood glucose excursions in general, and postprandial hyperglycemia in diabetic patients in particular, by the 1,5-anhydroglucitol assay (1,5-AG) or A1C/1,5-AG assay combination. 1,5-AG levels and percent changes of 1,5-AG leve... | 05/15/2012 |
| 8114623 | Method for determining glucose concentration in tissue fluid The invention relates to a method and a device for determining the glucose concentration in tissue fluid whereby test values for glucose and for an endogenous reference substance are detected in a sample liquid obtained by microdialysis, microperfusion or ultrafiltr... | 02/14/2012 |
| 8101374 | Oxidative chromogenic compound or salt thereof and production method thereof, and reagent composition and test instrument using the same It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the ... | 01/24/2012 |
| 8088595 | Method for glucose monitoring using fluorescence quenching This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecul... | 01/03/2012 |
| 8080385 | Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated,... | 12/20/2011 |
| 7964372 | Size self-limiting compositions and test devices for measuring analytes in biological fluids A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive sys... | 06/21/2011 |
| 7935499 | Method and device for predicting physiological values The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embo... | 05/03/2011 |
| 7910323 | Methods for identifying the effect of a drug agent on the metabolism of sugars and fats in an individual Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting ... | 03/22/2011 |
| 7892775 | Fluorescence assay for kinase activity The present invention provides a sensor and methods for determining kinase activity. ... | 02/22/2011 |
| 7867728 | Determining the concentration of analytes in sample by direct mediation of enzymes The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator. ... | 01/11/2011 |
| 7833742 | Treatment of α-galactosidase A deficiency The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included. ... | 11/16/2010 |
| 7790693 | Glucose-transport related genes, polypeptides, and methods of use thereof Methods and compositions for modulating glucose transport are provided herein. ... | 09/07/2010 |
| 7709221 | Biosensor with inorganic-organic hybrid polymer coating The present invention relates to a biosensor comprising a substrate with a coating system in which a Ruthenium complex and an enzyme is integrated. The enzyme is able to convert bioproducts, e.g. glucose, fructose or glycerol. The depletion of oxygen during these co... | 05/04/2010 |
| 7704704 | Implantable system for glucose monitoring using fluorescence quenching This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce ... | 04/27/2010 |
| 7670794 | Managing glycemia status in diabetic patients Methods for monitoring and managing glycemia status in a diabetic patient are disclosed. The methods comprise measuring in a diabetic patient, serum concentrations of HbA1c, glucose and inorganic phosphate and comparing the measured concentrations with reference con... | 03/02/2010 |
| 7651845 | Method and apparatus for glucose control and insulin dosing for diabetics A computer implemented method and associated apparatus for the combined control of insulin bolus dosing and basal delivery for the goal of achieving normal glycemic response to meals, exercise, stressors, and other perturbations to blood glucose levels. A run-to-run... | 01/26/2010 |
| 7615360 | Use of mutants for expressing mammalian glucose transporter The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains. ... | 11/10/2009 |
| 7611859 | Method for improving heat stability of composition containing water-soluble coenzyme-bound glucose dehydrogenase (GDH) The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH), comprising a step of combining, in a composition comprising soluble coenzyme-bound glucose dehydrogenase (GDH), the enzyme with any one or more selected from the group... | 11/03/2009 |
| 7595170 | Apparatus and method for measuring concentrations of molecules through a barrier An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms... | 09/29/2009 |
| 7592151 | Redox polymers for use in electrochemical-based sensors A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer ar... | 09/22/2009 |
| 7563588 | Electrically non-conductive, nanoparticulate membrane An electrically non-conductive, nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIIB or VIIIB of the Periodic Table, and wherein an oxidoreductase e... | 07/21/2009 |
| 7556934 | Concentration measurement by sensing hydrogel pressure A sensor and method for measuring the concentration of one or more chemical substances within a solution. The sensor including a body of saturated hydrogel held within a sensor body. A window to allow flow through of the chemical substance to be measured. The hydrog... | 07/07/2009 |
| 7537909 | Enzymatic method of producing 4-O-β-D-galactopyranosyl-D-xylose, 4-O-β-D-galactopyranosyl-D-xylose obtained using said method, compositions contain same and the use thereof in evaluating intestinal lactase An enzymatic process to obtain 4-O-β-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of preparing a reaction mixture of D-xylose, a β-D-galactopyranoside a... | 05/26/2009 |
| 7537910 | Lactamase amplification substrate An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon opening of the β-lactam ring the enzyme donor fragment becomes linearized.... | 05/26/2009 |
| 7517664 | Inactivated enzyme variants and associated process and reagent system The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors con... | 04/14/2009 |
| 7510849 | OCT based method for diagnosis and therapy This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsa... | 03/31/2009 |
| 7504233 | Methods for determining the metabolism of sugars and fats in an individual Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting ... | 03/17/2009 |
| 7439033 | Method and test strip for determining a fluid analyte A reagent strip for measuring the concentration of glucose in whole blood has a polymer on at least one side thereof to increase the opacity thereof, thereby reducing the effect of hematocrit on the glucose determination. ... | 10/21/2008 |
| 7435569 | Method of forming a molded protein matrix for use in a sensor A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical ... | 10/14/2008 |
| 7432096 | Glucose dehydrogenase and production thereof The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems. ... | 10/07/2008 |
| 7432353 | Fluorescent indicator proteins A protein biosensor having increased signal intensity to sugar concentration and the use thereof. A fluorescent indicator protein is described, in which fluorescent proteins of different emission ranges are fused to both ends of a binding protein undergoing a confor... | 10/07/2008 |
| 7432069 | Biocompatible chemically crosslinked hydrogels for glucose sensing An hydrogel incorporating a biologically active component is provided that is useful as an interface material for transdermal sensing applications. Specifically, the hydrogel has a crosslinked gel structure and a biologically active component incorporated into the c... | 10/07/2008 |
| 7429630 | Redox polymers for use in electrochemical-based sensors A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer ar... | 09/30/2008 |
| 7429462 | Kits for assays of rapid screening of diabetes The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydra... | 09/30/2008 |
| 7427491 | Nanoparticles for optical sensors The present invention concerns a polymer layer for a sensor, wherein the polymer layer has nanoparticles embedded therein which impart to the polymer layer recognizing properties as well as transducer properties, a sensor comprising such layer and the use of the sen... | 09/23/2008 |
| 7416843 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expos... | 08/26/2008 |
| 7407626 | Composition and method of use of medical test kit A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood testing composition, a calcium testing composition, a nitrite testing ... | 08/05/2008 |
| 7405055 | Method and device for predicting physiological values The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embo... | 07/29/2008 |
