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| Number | Title | Issue Date |
| 7960152 | Methods for production of xylitol in microorganisms The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates. ... | 06/14/2011 |
| 7256027 | Enzymes for the production of 2-keto-L-gulonic acid Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/... | 08/14/2007 |
| 7244596 | Separation of biomass from lactic-acid containing fermentation products by means of flocculation The present invention is in the field of the preparation of lactic acid by means of fermentation, more particularly it is directed to processes to separate the biomass from the lactic acid-containing fermentation product by means of flocculation. We have foun... | 07/17/2007 |
| 7241587 | Method of uncoupling the catabolic pathway of glycolysis from the oxidative membrane bound pathway of glucose conversion The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding a... | 07/10/2007 |
| 7229811 | 2,5-diketo-D-gluconic acid (2,5-DKG) permeases The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, whi... | 06/12/2007 |
| 7229795 | 2,5-DKG permeases The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, whi... | 06/12/2007 |
| 7195792 | Browning agent A browning agent for foodstuffs having at least two carbonyl groups is disclosed. A method for using the browning agent in or on a substrate is also disclosed. The browning agent may be coated onto foodstuffs such as biscuits, pizza, pie coverings or hash brown pota... | 03/27/2007 |
| 7135315 | Aldehyde dehydrogenase gene The present invention relates to a novel DNA which encodes aldehyde dehydrogenase (SNDH), an expression vector containing the DNA and recombinant organisms containing said DNA. Furthermore, the present invention concerns a process for producing recombinant aldehyde ... | 11/14/2006 |
| 7109004 | Process for reducing an alpha-keto ester A process for preparing (R)-hydroxy ester (II) from alpha-keto ester I comprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enz... | 09/19/2006 |
| 7105297 | Methods and compositions for cellular and metabolic engineering The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of reco... | 09/12/2006 |
| 7091013 | Process for the manufacture of 2-keto-L-gulonic acid The present invention discloses a process for producing sodium 2-keto-L-gulonate from sorbitol and recovering 2-keto-L-gulonic acid in high recovery yields, by controlled cation exchange treatment of the micro-organism free fermentation broth and/or adjusting PII of... | 08/15/2006 |
| 7033824 | shuttle vectors The present invention relates, in general, to vectors comprising Ketogulonigenium replicons. More specifically, the present invention relates to vectors comprising a Ketogulonigenium replicon found on the endogenous plasmid contained in Deposit No. NRR... | 04/25/2006 |
| 7033804 | Methods for the production of products in host cells The invention provides methods and host cells for the production of ascorbic acid intermediates. The invention also provides host cells having a modification in a polynucleotide that uncouples the catabolic pathway from the oxidative pathway by deleting the encoding... | 04/25/2006 |
| 6916646 | Enterobacteriaceae fermentation strains Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby creating the improved strain. Methods for reducing the mobilization prope... | 07/12/2005 |
| 6902917 | Process for recovery of organic acids from fermentration broths The present invention relates to a process for the recovery of an organic acid from a fermentation broth which comprises drying the fermentation broth to obtain a dried product, adding the dried product to a lower alcohol in the presence of an acid, and then removin... | 06/07/2005 |
| 6824996 | Production of ascorbic acid The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source. ... | 11/30/2004 |
| 6730503 | Alcohol/aldehyde dehydrogenase The present invention is directed to a recombinant enzymes having alcohol and aldehyde dehydrogenase activity which comprises one or mom recombinant polypeptides selected from the group consisting of polypeptides which are identified by SEQ ID NO 5, SEQ ID NO 6, SEQ... | 05/04/2004 |
| 6670505 | Process for the recovery of organic acids from aqueous solutions A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired lev... | 12/30/2003 |
| 6541228 | Electrodialysis methods for purification and recovery of gluconic acid derivatives A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic acid derivative an... | 04/01/2003 |
| 6399340 | Vector derivatives of gluconobacter plasmid pF4 A DNA derived from plasmid pF4, which contains a region involved in the control of autonomous replication in a bacterial cell belonging to the genus Gluconobactor, with or without a part of the polynucleotide region not essential for the autonomous replic... | 06/04/2002 |
| 6358715 | Production of ascorbic acid The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source.... | 03/19/2002 |
| 6319699 | Bacterial strains and use thereof in fermentation processes for 2-keto-l-gulonic acid protection The present invention relates to a process for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorbose and/or D-sorbitol. The present invention further relates to novel bacterial strains useful in this process.... | 11/20/2001 |
| 6316231 | Bacterial strains for the production of 2-keto-L-gulonic acid The present invention relates to novel bacterial strains useful for the production of 2-keto-L-gulonic acid. The present invention further relates to the use of these strains for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorb... | 11/13/2001 |
| 6271006 | Enzymatic process for the manufacture of ascorbic acid, 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid The present invention is directed toward efficient, high-yield processes for making ascorbic acid, 2-keto-L-gulonic acid, and esters of 2-keto-L-gulonic acid. The processes comprise reacting the appropriate starting materials with a hydrolase enzyme catal... | 08/07/2001 |
| 6238897 | Continuous process for producing 2-keto-L-gulonic acid A process for the continuous production of 2-keto-L-gulonic acid or a salt thereof from D-sorbitol by fermentation with microorganisms in a nutrient medium containing D-sorbitol that is incubated in a first fermentation vessel with a microorganism capable... | 05/29/2001 |
| 6187570 | Electrodialysis methods for purification and recovery of gluconic acid derivatives A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic acid derivative an... | 02/13/2001 |
| 6022719 | Enzymatic process for the manufacture of ascorbic acid, 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid The present invention is directed toward efficient, high-yield processes for making ascorbic acid, 2-keto-L-gulonic acid, and esters of 2-keto-L-gulonic acid. The processes comprise reacting the appropriate starting materials with a hydrolase enzyme catal... | 02/08/2000 |
| 5998180 | Nitrilase from Rhodoccus rhodochrous for converting acrylonitrile directly to acrylic acid Nitrilase enzymes are provided which have Km at pH 7.0 for acrylonitrile of 500 μM or below. The enzymes also have Ki at pH 7.0 for ammonium acrylate of at least 100 mM. In particular, the nitrilases have a value of the ratio of the said Ki to the said K... | 12/07/1999 |
| 5989891 | Bacterial stains and use thereof in fermentation processes for 2-keto-L-gulonic acid production The present invention relates to a process for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorbose and/or D-sorbitol. The present invention further relates to novel bacterial strains useful in this process.... | 11/23/1999 |
| 5932463 | Gluconobacter alcohol/aldehyde dehydrogenase The present invention relates to a novel alcohol/aldehyde dehydrogenase (hereinafter referred to as AADH), a process for producing the same and a process for producing aldehydes, carboxylic acids and ketones, especially 2-keto-L-gulonic acid (hereinafter ... | 08/03/1999 |
| 5916785 | Process of oxidizing alcohols or carboxylic acids with alcohol/aldehyde dehydrogenase from gluconobacter The present invention relates to a novel alcohol/aldehyde dehydro-genase (hereinafter referred to as AADH), a process for producing the same and a process for producing aldehydes, carboxylic acids and ketones, especially 2-keto-L-gulonic acid (hereinafter... | 06/29/1999 |
| 5900370 | Process for the production of ascorbic acid with prototheca The present invention is directed to methods for the production of ascorbic acid by culturing organisms of the genus Prototheca and recovering ascorbic acid from the fermentation medium.... | 05/04/1999 |
| 5888786 | Method for producing 2-keto-L-gulonic acid An expression vector containing both a DNA encoding an L-sorbose dehydrogenase and a DNA encoding an L-sorbosone dehydrogenase; a transformant having an ability to produce 2-keto-L-gulonic acid (hereinafter 2KLGA) at high yields from D-sorbitol, which is ... | 03/30/1999 |
| 5834263 | Method for producing 2-keto-L-gulonic acid An expression vector containing both a DNA encoding an L-sorbose dehydrogenase and a DNA encoding an L-sorbosone dehydrogenase; a transformant having an ability to produce 2-keto-L-gulonic acid (hereinafter 2KLGA) at high yields from D-sorbitol, which is ... | 11/10/1998 |
| 5834231 | Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production The present invention relates to a process for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorbose and/or D-sorbitol. The present invention further relates to novel bacterial strains useful in this process.... | 11/10/1998 |
| 5804423 | Microbiological method of making 5-ketogluconate A method is disclosed for preparing 5-ketogluconate, which comprises the steps of: (a) genetically modifying a microorganism capable of microbiologically producing 5-ketogluconate to increase gluconate NADP+ -5-oxidoreductase gene expression of... | 09/08/1998 |
| 5795761 | Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A Mutants of 2,5-diketo-D-gluconic acid reductase A an enzyme used to produce 2-keto-L-gluconic acid, a precursor of ascorbic acid (vitamin C), are prepared by site-directed mutagenesis. These mutants may exhibit one or more of the following characteristics... | 08/18/1998 |
| 5792631 | Microbial process for the production of ascorbic acid using Chlorella protothecoides The present invention is directed to methods for the production of ascorbic acid by culturing organisms of the species C. protothecoides and recovering ascorbic acid from the fermentation medium.... | 08/11/1998 |
| 5776742 | Aldehyde dehydrogenase enzyme An aldehyde dehydrogenase having the physico-chemical properties: molecular weight: 91,000&#b1;5,000; substrate specificity:active on aldehyde compounds; inhibition: by Cu2+, Zn2+, Ni2 + and ethylenediamine tetraacetic aci... | 07/07/1998 |
| 5759826 | Process of preparing an organic acid A process is disclosed for preparing an organic acid and/or its salts from a solution obtained through fermentation. In this process, a pure carbohydrate-containing raw material is used. The acid-containing solution prepared by means of fermentation is su... | 06/02/1998 |
