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| Number | Title | Issue Date |
| 8143035 | Pantothenate kinase overexpression and pantothenic acid supplementation in actinomycetes The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary m... | 03/27/2012 |
| 8129153 | Control of enzymatic peracid generation A process is provided for producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having... | 03/06/2012 |
| 8129152 | Method of producing enantioselective immobilized candida rugosa lipase Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and Mg—Al-hydrotalcite enhances its enantioselectivity by six to seven folds. The imm... | 03/06/2012 |
| 8124386 | Methods and systems for biomass conversion to carboxylic acids and alcohols The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts ... | 02/28/2012 |
| 8105810 | Method for producing peroxycarboxylic acid Disclosed herein are two-component enzymatic peracid generation systems and methods of using such systems wherein the first component comprises a formulation of at least one enzyme catalyst having perhydrolysis activity, a carboxylic acid ester substrate, and a coso... | 01/31/2012 |
| 8058038 | Aldolase and production process of substituted α-keto acids 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwi... | 11/15/2011 |
| 8039238 | Method of controlling ethanol production and mass production of lactic acid and transformant therefor The present invention provides a transformant into which has been incorporated DNA for coding a foreign protein having lactate dehydrogenase activity and provided with pyruvic acid substrate affinity that equals or exceeds the pyruvic acid substrate affinity of the ... | 10/18/2011 |
| 8030038 | Stabilization of perhydrolases Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carb... | 10/04/2011 |
| 8003356 | Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively... | 08/23/2011 |
| 7964378 | Production of peracids using an enzyme having perhydrolysis activity A method is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity de... | 06/21/2011 |
| 7955825 | Process for producing CMP-N-acetylneuraminic acid The present invention is directed to a process for producing CMP-N-acetylneuraminic acid (CMP-NeuAc), comprising adding to the cultured E. coli cells which has been transformed with both the DNA encoding N-acetylglucosamine-6-phosphate 2-epimerase (GlcNAc-6P ... | 06/07/2011 |
| 7951567 | Production of peracids using an enzyme having perhydrolysis activity A method is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity de... | 05/31/2011 |
| 7951566 | Production of peracids using an enzyme having perhydrolysis activity A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. ... | 05/31/2011 |
| 7842483 | Cytochrome c oxidase enzyme complex The present invention is directed to a novel cytochrome c oxidase complex, genetic materials useful for the preparation of the said complex, such as recombinant polypeptides involved in cytochrome c oxidase complex, recombinant DNA fragments, expression vectors, rec... | 11/30/2010 |
| 7829315 | Production of peracids using an enzyme having perhydrolysis activity A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. ... | 11/09/2010 |
| 7820417 | Methods and systems for biomass conversion to carboxylic acids and alcohols The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts ... | 10/26/2010 |
| 7807425 | Production of peracids using an enzyme having perhydrolysis activity A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. ... | 10/05/2010 |
| 7803586 | Chemical Process Enzymatic and chemical processes for the preparation of certain of 3-phenyl-2-arylalkylthiopropionic acid derivatives which have utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance and o... | 09/28/2010 |
| 7799545 | Microorganisms for the production of adipic acid and other compounds The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid o... | 09/21/2010 |
| 7749740 | Microbial production of pyruvate and pyruvate derivatives Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources. ... | 07/06/2010 |
| 7723083 | Production of peracids using an enzyme having perhydrolysis activity A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. ... | 05/25/2010 |
| 7632665 | Coupled cofactor-dependent enzymatic reaction systems in aqueous media The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a ... | 12/15/2009 |
| 7629155 | Process for producing 1,4-dihydroxy-2-naphthoic acid A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This comp... | 12/08/2009 |
| 7625727 | Process for producing mycophenolic acid using BICC 7673 The present invention discloses the manufacture of MPA by fermentation under optimal fermentation parameters using a new strain of Penicillium arenicola. ... | 12/01/2009 |
| 7517675 | Oxidation of carbohydrates by means of peroxidases and nitroxy radicals A method of oxidising carbohydrates and/or carbohydrate derivatives having primary alcohol groups comprising contacting a reaction medium containing said carbohydrates and/or carbohydrate derivatives with a nitroxy radical mediator and a peroxidase enzyme, character... | 04/14/2009 |
| 7479381 | Production of itaconic acid by Itaconic acid may be produced in high yields by fermentation with a yeast, Pseudozyma antarctica NRRL Y-30980. ... | 01/20/2009 |
| 7439045 | pH controlled fermentation process for pseudomonic acid production An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of ... | 10/21/2008 |
| 7413883 | Enantioselective immobilized lipase Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and Mg—Al-hydrotalcite enhances its enantioselectivity by six to seven folds. The imm... | 08/19/2008 |
| 7374915 | Process for producing 1,4-dihydroxy-2-naphthoic acid A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This comp... | 05/20/2008 |
| 7368267 | Method for the oxidation of aromatic compounds The invention relates to a process for the biocatalytic oxidation of aromatic compounds using recombinant xylene monooxygenase-expressing microorganisms in a biphasic reaction medium. ... | 05/06/2008 |
| 7358071 | Production of 3-hydroxycarboxylic acid using nitrilase mutants This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidovorax facilis 72W (ATCC 55746) nitrilase gene was mutated using error-prone PCR and site-... | 04/15/2008 |
| 7351559 | Process for producing ethanol A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, u... | 04/01/2008 |
| 7344869 | Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and hosts capable of improved clavulanic acid production Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid. ... | 03/18/2008 |
| 7332354 | Compounds for chemiluminescense procedures The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converte... | 02/19/2008 |
| 7314739 | Lipase variants The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the po... | 01/01/2008 |
| 7300771 | Process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes A process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes is disclosed. ... | 11/27/2007 |
| 7270947 | Method for controlling biooxidation reactions Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate ... | 09/18/2007 |
| 7262037 | Method for the production of D-(-)-3-hydroxybutyric acid by recombinant This invention relates to a method for the production of D-(−)-3-hydroxybutyric acid, comprising the step of culturing a recombinant strain containing genes phbA, phbB, ptb and buk by fermentation. Preferably, the recombinant strain is a strain of E. coli. ... | 08/28/2007 |
| 7259295 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 08/21/2007 |
| 7256022 | Pufa polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 08/14/2007 |
