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| Number | Title | Issue Date |
| 8163525 | Method of expressing long-chain prenyl diphosphate synthase The present disclosure describes a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a protein which are required for enabling or enhancing the activity ex... | 04/24/2012 |
| 8114642 | Method for producing vitamin K2 from culture of A method for producing vitamin K2 comprising: culturing Bacillus natto in a liquid medium to obtain a Bacillus natto culture or culture supernatant thereof, wherein the culture or culture supernatant contains vitamin K2; treating the culture or culture... | 02/14/2012 |
| 8080397 | Biocatalystic synthesis of quinic acid and conversion to hydroquinone by recombinant microbes A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided. ... | 12/20/2011 |
| 7910340 | Processes for producing coenzyme Q10 The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally ... | 03/22/2011 |
| 7718407 | Process for the preparation of vitamin K2 A process for the preparation of vitamin K2 (MK-7) comprising the culture of Bacillus subtilis mutant strain GN13/72-DSM 17766 deposited on Dec. 5, 2005 at the DSMZ. ... | 05/18/2010 |
| 7572609 | Production of isoprenoids The present invention relates to a process for the production of isoprenoids Coenzyme Q-10 by microorganisms. More particularly, the present invention relates to a process for increased production of Coenzyme Q-10 by microorganisms of the genus Rhodobacter, p... | 08/11/2009 |
| 7435565 | culture extract A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μ/g or less of vitamin K2/g dry weight is obtained. ... | 10/14/2008 |
| 7422878 | Process for microbial production of ubiquinone-10 using The present invention provides a process for producing ubiquinone-10 using a microorganism having the ability to form ubiquinone-10 and having one or more properties selected from the group consisting of the property wherein geranylgeranyltransferase activity is red... | 09/09/2008 |
| 7402413 | Method of expressing long-chain prenyl diphosphate synthase The present invention provides a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a protein which are required for enabling or enhancing the activity expr... | 07/22/2008 |
| 7374901 | Method of analyzing coenzyme Q-10 and two-electron reduction product thereof and analysis system The present invention relates to an analysis method and analysis system that can accurately analyze the contents of coenzyme Q-10 and a 2-electron reduced form thereof in a specimen, in which human blood plasma as the specimen is mixed with isopropyl alcohol as a pr... | 05/20/2008 |
| 7348166 | Anti-tumor substances An anti-tumor substance may be produced from a tumor cell-derived material by Staphylococcus. The anti-tumor substance may include a chemical compound having the formula: Staphylococcus may preferably be St... | 03/25/2008 |
| 7320883 | Process for producing coenzyme Q The invention aims at providing a process for producing coenzyme Q10 efficiently in microorganisms by utilizing a coenzyme Q10 side chain synthesis gene derived from a fungal species belonging to the genus Aspergillus and genus Leucos... | 01/22/2008 |
| 7169590 | Method of stabilizing reduced coenzyme Qand method of acidic crystallization The present invention relates to a method of efficiently producing reduced coenzyme Q10 having excellent qualities which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal dru... | 01/30/2007 |
| 7002047 | Biocatalytic synthesis of quinic acid and conversion to hydroquinone A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided. ... | 02/21/2006 |
| 6677143 | Method for culturing Bacillus subtilis natto to produce water-soluble vitamin K and food product, beverage, or feed containing the cultured microorganism or the vitamin K derivative A method for culturing Bacillus subtilis in such a manner that a vitamin K derivative is accumulated in the largest amount in the cells of the microorganism. A method for the culture of Bacillus subtilis, which comprises culturing Bacillus subtilis and re... | 01/13/2004 |
| 6677141 | Edible compositions of Bacillus subtilis natto cells containing water-soluble vitamin K A method for culturing Bacillus subtilis in such a manner that a vitamin K derivative is accumulated in the largest amount in the cells of the microorganism. A method for the culture of Bacillus subtilis, which comprises culturing Bacillus subtilis and re... | 01/13/2004 |
| 6620602 | Biocatalytic synthesis of quinic acid and conversion to hydroquinone A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided... | 09/16/2003 |
| 6600077 | Biocatalytic synthesis of quinic acid and conversion to hydroquinone A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided... | 07/29/2003 |
| 6531591 | Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-ol... | 03/11/2003 |
| 6511820 | Bacterial strains for the production of Pyrroloquinoline Quinone The present invention relates to novel bacterial strains useful for the production of 2-keto-L-gulonic acid. The present invention further relates to the use of these strains for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorb... | 01/28/2003 |
| 6506583 | Bacterial strains for the production of 2-keto-L-gulonic acid The present invention relates to novel bacterial strains useful for the production of 2-keto-L-gulonic acid. The present invention further relates to the use of these strains for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorb... | 01/14/2003 |
| 6410280 | Decaprenyl diphosphate synthetase gene The present invention provides a prenyl diphosphate synthetase and a gene coding for the synthetase. The invention discloses a recombinant protein having the amino acid sequence shown in SEQ ID NO:2 or a recombinant protein which has the amino acid sequen... | 06/25/2002 |
| 6214573 | Recombinant production of novel polyketides Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn ca... | 04/10/2001 |
| 6066656 | 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to... | 05/23/2000 |
| 5846788 | Process for preparing a lignocellulose-based product, and product obtainable by the process A process for the manufacture of a lignocellulose-based product from a lignocellulosic material comprises treating the lignocellulosic material and a phenolic polysaccharide having substituents containing a phenolic hydroxy group with an enzyme capable of... | 12/08/1998 |
| 5798236 | Synthesis of quinic acid from glucose There are described methods for the synthesis of quinoid organic compounds from a renewable energy source such as glucose. The method comprises enhancing the amount of glucose equivalents introduced into the pathway, blocking the common pathway so as to a... | 08/25/1998 |
| 5773291 | Non-melanotytic mammalian cell constitutively expressing biologically active human tyrosinase and use thereof This invention provides a non-melanocytic eucaryotic cell constitutively expressing biologically active human tyrosinase. The present invention also provides methods of producing biologically active human tyrosinase. Additionally, the invention provides a... | 06/30/1998 |
| 5631151 | Melanin production by transformed organisms The present invention is directed to a process for producing melanins, their precursors and their analogues, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet wei... | 05/20/1997 |
| 5484708 | Method for the colorimetric determination of an analyte with a PQQ-dependent dehydrogenase The invention concerns a method for the colorimetric determination of an analyte by means of enzymatic oxidation with a PQQ-dependent dehydrogenase in the presence of an electron acceptor from the group of the electron-rich aromatic nitroso compounds by e... | 01/16/1996 |
| 5156962 | Process for producing carboxylic acid esters using carboxyesterase and an anhydride in organic solvent A process for producing a carboxylic acid ester which comprises reacting a hydroxy compound for example a primary or secondary alcohol, lankacidin C or maridomycin with a carboxylic anhydride in the presence of carboxylesterase as a catalyst in an organic... | 10/20/1992 |
| 4994382 | Process for production of pyrrolo-quinoline quinone There are disclosed a new process for production of pyrrolo-quinoline quinone, comprising culturing a bacterium belonging to the genus Paracoccus, Protaminobacter or Pseudomonas and capable of producing pyrrolo-quinoline quinone in a culture medium to pro... | 02/19/1991 |
| 4849354 | Process for producing menaquinone-4 Menaquinone-4 is produced by cultivating in culture media a microorganism belonging to the genus Corynebacterium Arthrobactor, Brevibacterium, Microbacterium, Cutobacterium, Auteobacterium or Flavobacterium which produces menaquinone-4 and recovering the ... | 07/18/1989 |
| 4824780 | Method for producing hydroquinone Hydroquinone is isolated from the reaction medium resulting from contacting cultured Mycobacterium cells containing an oxygenase with benzene and/or phenol in the presence of molecular oxygen or air and aqueous medium.... | 04/25/1989 |
| 4717664 | Method for producing secondary metabolites of plants This invention provides for a method for producing secondary metabolites of higher plants, such as Lithospermum erythrorhizon, Coptis japonica, and Nicotinia tabacum, by suspension cultures of a mass of undifferentiated cells (callus). The cultures are ca... | 01/05/1988 |
| 4447362 | Process for the production of coenzyme Q A process is disclosed wherein coenzyme Q is prepared from tissues of animals and plants or microbial cells by treating a water suspension of said materials with an alkali, or with an acid and then an alkali, and by extracting the treated suspension with ... | 05/08/1984 |
| 4414226 | 1,4-Naphtoquinone derivatives and their use in treating coccidiosis 1,4-naphthoquinone derivatives represented by the following general formula: ##STR1## (wherein R1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R2 represents a carboxy group, an est... | 11/08/1983 |
| 4367288 | Method for producing coenzyme Q10 Coenzyme Q10 can be produced extremely quickly in exceedingly high yield in a simple industrial process by cultivating a microorganism of genus Aureobasidium or Trichosporon in a culture medium containing a large quantity of p-hydroxy benzoic a... | 01/04/1983 |
| 4367289 | Method of producing coenzyme Q10 Coenzyme Q10 which is useful as a raw material of medicines for curing various diseases such as heart diseases, hypertension, etc. can economically be mass produced in a culture medium containing an extremely large quantity of p-hydroxybenzoic ... | 01/04/1983 |
| 4245048 | Process for producing coenzyme Q10 The invention provides a process for producing coenzyme Q10 by cultivating a novel microorganism JY-155 which belongs to the genus Trichosporon (FERM-P4650, ATCC 20566) which we discovered, in a culture medium containing sulfite waste liquor as... | 01/13/1981 |
| 4220719 | Process for the production of Coenzyme Q10 A process for producing Coenzyme Q10 which comprises cultivating a microorganism belonging to genus Cryptococcus, Rhodotorula, Sporobolomyces, Torulopsis, Sporidiobolus, Oosporidium, Aspergillus, and Cladosporium in a culture medium to which is... | 09/02/1980 |
