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| Number | Title | Issue Date |
| 8178324 | Deracemisation of amines The present invention relates to a method for the deracemization or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion... | 05/15/2012 |
| 8168412 | Method for producing optically-active amine compound, recombinant vector, and transformant containing the vector The present invention relates to a method for producing an optically-active amine compound. The method is characterized by using a transaminase (A), an α-keto acid reductase (B), and an enzyme (C), each having specific properties, in an identical reaction system to... | 05/01/2012 |
| 8133705 | Aminotransferase, gene encoding the same, and method of using them The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an op... | 03/13/2012 |
| 8088607 | Microorganisms for the production of adipic acid and other compounds The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid o... | 01/03/2012 |
| 8071340 | Biocatalytic process for the production of ortho-aminophenols from chloramphenicol and analogs A process for the production of ortho-aminophenolic analogs of chloramphenicol using a biocatalyst consisting of pure enzymes, partially purified enzymes, cell lysate, intact cells, or a metal reaction linked with a subsequent enzymatic reaction. The biocatalyst is ... | 12/06/2011 |
| 8039236 | Process for producing dipeptides The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes ... | 10/18/2011 |
| 7939302 | Process for producing dipeptides The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the abil... | 05/10/2011 |
| 7932064 | Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hyd... | 04/26/2011 |
| 7915019 | Processes for preparing optically active (S or R)-β-amino acid and optically active (R or S)-β-amino acid ester, and β-amino acid 2-alkoxyethyl ester and optically active (S or R)-β amino acid 2-alkoxyethyl ester A process for preparing an optically active (S or R)-β-amino acid represented by formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, ar... | 03/29/2011 |
| 7867736 | Method for preparing an organic amine—lactic acid complex The invention relates to a method for preparing a complex of an organic amine and lactic acid in a reactor, characterized in that a water-miscible organic amine is brought into contact with magnesium lactate in an aqueous medium in the reactor to form the complex an... | 01/11/2011 |
| 7807423 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and comp... | 10/05/2010 |
| 7759095 | Process for the preparation and isolation of phosphatides Process for the preparation of phosphatidylserine of formula wherein R1 and R2 independently represent a saturated, mono-unsaturated or polyunsaturated acyl C10-C30, X=OH or OM wh... | 07/20/2010 |
| 7741082 | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure ... | 06/22/2010 |
| 7642073 | Method for reductive amination of a ketone using a mutated enzyme Methods for chemically transforming compounds using a mutated enzyme are provided, and more particularly a method for the production of an amine from a target ketone. The methods comprise creating a mutated enzyme that catalyzes the reductive amination of the target... | 01/05/2010 |
| 7575906 | Catalase decomposition of hydrogen peroxide in surfactants A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme. ... | 08/18/2009 |
| 7572608 | -hydroxynitrillyases having improved substrate tolerance and the use thereof The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, vali... | 08/11/2009 |
| 7531330 | Modified S-hydroxynitrile lyase This invention relates to S-hydroxynitrile lyase having excellent tolerance to heat, organic solvents, and the like, which is obtained by modifying at least one amino acid in the helix D3, helix A, and β-sheet 2 domains in the amino acid sequence of wild-type S-hyd... | 05/12/2009 |
| 7514243 | Process for producing dipeptides The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the abil... | 04/07/2009 |
| 7514242 | Process for producing dipeptides The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes ... | 04/07/2009 |
| 7491520 | Biochemical synthesis of 6-amino caproic acid The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group... | 02/17/2009 |
| 7432102 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, ther... | 10/07/2008 |
| 7407779 | Modification of solid 3-sn-phosphoglycerides Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structur... | 08/05/2008 |
| 7405064 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 07/29/2008 |
| 7399616 | Enzymatic synthesis of N-acyl-L-arginine esters The invention relates to a process for preparing a Na-acyl-L-arginine ester, derived from fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X— is Br—, Cl—, or HSO4— R1: is linear alkyl chain from an saturated fatt... | 07/15/2008 |
| 7374926 | Enantioconvergent chemoenzymatic synthesis of ()-γ-amino-β-hydroxybutyric acid (()-GABOB) The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its race... | 05/20/2008 |
| 7364882 | Enzymatic reduction of a nitrile containing compound to the corresponding amine A new class of enzymes that catalyze the conversion of a nitrile containing compound to the corresponding amine (such as a primary amine) are disclosed. Such enzymes are referred to herein as nitrile oxido-reductases. Methods of using the enzymes to reduce a nitrile... | 04/29/2008 |
| 7364881 | Biological process for the conversion of nitroarenes to ortho-aminophenols using recombinant strains A process for biological production of ortho-aminophenols from nitroaromatic compounds using recombinant E. Coli strains. The process uses an enzyme system that makes use of a nitroreductase enzyme that initially reduces the nitroarene to the hydroxylaminoare... | 04/29/2008 |
| 7351786 | Polyhydroxyalkanoate containing unit having cyclohexyl structure at side chain, production process therefor, and binder resin containing polyhydroxyalkanoate Disclosed are a polyhydroxyalkanoate, containing in a polymer molecule thereof a monomer unit represented by the following general formula (1): (wherein R1 represents a substituent to a cyclohexyl group, where R1 is a H ato... | 04/01/2008 |
| 7338792 | Process for the preparation of D-pantothenic acid and/or salts thereof The invention provides a process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Bacillus group, in particular those which already produce D-pantothenic acid, whi... | 03/04/2008 |
| 7332297 | Enzymatic polymerization The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to... | 02/19/2008 |
| 7319027 | Thermostable Omega-Transaminases Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereosel... | 01/15/2008 |
| 7316918 | Process for the preparation of (−) modafinil An enzymatic process for the preparation of intermediates useful in the synthesis of (−) modafinil. ... | 01/08/2008 |
| 7309582 | Polymer-template complex produced by enzymatic polymerization The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to... | 12/18/2007 |
| 7309590 | Method for producing an aqueous acrylamide solution with a biocatalyst The invention relates to a method and device for producing an aqueous acrylamide solution by hydrating acrylonitrile in an aqueous solution while in the presence of a biocatalyst. ... | 12/18/2007 |
| 7294493 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 11/13/2007 |
| 7291490 | Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and pro... | 11/06/2007 |
| 7276360 | Thermostable omega-transaminases Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereosel... | 10/02/2007 |
| 7267969 | Thermostable omega-transaminases Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereosel... | 09/11/2007 |
| 7264952 | Thermostable omega-transaminases Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereosel... | 09/04/2007 |
| 7255813 | NADH/NADPH-containing compound The invention relates to a compound containing at least one health promoting isolated antioxidant A having a redox potential of less than 180 mV and at least one stabilising antioxidant B which has a standard redox potential which is less than the standard redox pot... | 08/14/2007 |
