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| Number | Title | Issue Date |
| 8148119 | Hydroxylase gene and use thereof A vitamin D3 hydroxylase is purified from Pseudonocardia autotrophica cell, and a primer is designed based on amino acid sequence obtained from hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseudonocardia autotrophica as a... | 04/03/2012 |
| 7972821 | Production of functional proteins: balance of shear stress and gravity A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-α-hydroxylase which can be us... | 07/05/2011 |
| 7790425 | Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol B The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of prod... | 09/07/2010 |
| 7432102 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, ther... | 10/07/2008 |
| 7354747 | Carbohydrate derived protein resistant biomaterial Carbohydrate-derived side-chain polyethers that may be synthesized by condensation polymerization of monomers derived from natural occurring carbohydrates. These compounds are protein resistant, biodegradable and may be functionalized at location other that the chai... | 04/08/2008 |
| 7335498 | Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol B The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of prod... | 02/26/2008 |
| 7294492 | Process for the manufacture of spiroketals The present invention is directed to the use of yeasts to produce spiroketal fragrance materials. The preferred yeasts used in the method of the invention are Bensingtonia ciliate and Cryptococcus laurentii. ... | 11/13/2007 |
| 7125692 | Process for producing monomer A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2 | 10/24/2006 |
| 7084171 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound... | 08/01/2006 |
| 6872517 | Early diagnosis of cancerous and precancerous conditions by leakage of signature peptides and carbohydrates into the bloodstream The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a biological sample obtained from the gastrointestinal tract. ... | 03/29/2005 |
| 6589765 | Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production of the paclitaxel comprises the following procedure: (i) ... | 07/08/2003 |
| 6586201 | Method of chromatographic isolation for non-glyceride components A method of chromatographic isolation for non-glyceride components (squalenes, carotenes, vitamin E, sterols and/or the like) from a non-glyceride components-comprising compound by the steps of a. introducing the non-glyceride components-comprising compound on... | 07/01/2003 |
| 6479657 | Crystalline 1-kestose and process for preparing the same A process for producing crystal 1-kestose wherein granular crystal 1-kestose in the form of large crystals can be produced at a high yield is disclosed. A highly pure solution of 1-kestose is concentrated to a Brix of 75 or higher; either seed crystals ar... | 11/12/2002 |
| 6472169 | Biocatalytic synthesis of shikimic acid A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.... | 10/29/2002 |
| 6428989 | Method for producing taxane-type diterpenes The present invention discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising one or both of the the following steps (a) and (b) to increase the ratio of those cell clusters sui... | 08/06/2002 |
| 6046041 | Method for producing marine-derived compounds and novel compounds produced therefrom A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g., sterols, to their corresponding metabolites, e.g., 9(11)-s... | 04/04/2000 |
| 5928910 | Antifungal substances BE-49385 and process for their production The present invention relates to a compound represented by the general formula (I): ##STR1## wherein R1 is a hydrogen atom, or ##STR2## and R2 is a hydrogen atom or OH and R2 is a hydrogen atom or a lower al... | 07/27/1999 |
| 5925550 | Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex The present invention relates to a method for selectively enhancing the production of factors A2 and/or A3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, ... | 07/20/1999 |
| 5861293 | Gene encoding glycosyltransferase and its uses This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof. This invention makes it possible to glycosylate indolopyrro... | 01/19/1999 |
| 5861277 | Methods and compositions for enhancing the expression of genes in plants Disclosed are methods of increasing exogenous protein expression in a cell or a transgenic plant. Constructs, i.e., vectors, DNA fusions and polynucleotides, for use in conjunction with the methods to cause increased exogenous protein expression are also ... | 01/19/1999 |
| 5840683 | Peptides inhibiting the oncogenic action of p21 ras The present invention provides peptides and cyclized peptides which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the ras-inhibiting peptides, cyclized peptides and peptid... | 11/24/1998 |
| 5801023 | Antiparasitic pyrrolobenzoxazine compounds This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: ##STR1## wherein R is hydrogen or chloro. Also, the present invention provides a process for the production of the compound of formula I, ... | 09/01/1998 |
| 5773264 | Process for the production of 17 -hydroxy-3-methoxy-8,14-seco-1,3,5(10),9(11)estratetraen-14-one by reduction of the corresponding 17-one compound A process for the production of 17-hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-seco-1,3,5(10),9(11) -estratetraene-14,17-dione with a live culture of Kloeckera magna is described, which is chara... | 06/30/1998 |
| 5763234 | Secosteroids, and method for producing same A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high yield. NAD, NADP, and glutamate dehydrogenase are key additives ... | 06/09/1998 |
| 5747303 | Intermediates of peptide antagonists of neurotensin The invention is directed to a novel compound of formula ##STR1## in which R is a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH2 --COOH radical, R' and R" are identical and are each a hydroxy or methoxy radical and R'" represents a hydrog... | 05/05/1998 |
| 5702929 | Antifungal agent There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.... | 12/30/1997 |
| 5593870 | Process for producing frenolicin B The present invention is directed to a process for producing frenolicin B. The process comprises fermenting a broth so as to produce frenolicin, said broth having a microorganism capable of producing frenolicin. The frenolicin is then converted in the bro... | 01/14/1997 |
| 5563054 | Process for preparation of benzo[B]thiophene glucuronides The present invention provides a biotransformation process for preparing a compound of the formula ##STR1## wherein R1 and R2 are hydrogen or a ଲ-glucuronide group of the formula ##STR2## provided at least one of... | 10/08/1996 |
| 5492819 | Recovery of insoluble biosynthetic products There is disclosed a process for the recovery of an insoluble fermentation product from a solid phase cell mass, the process comprising treating the fermentation broth to solubilize the cell mass and separating by known methods the liquid phase from the i... | 02/20/1996 |
| 5474923 | Method for the biological preparation of hydroxyvitamin D compounds A method for introducing hydroxyl groups into vitamin D compound at the 1- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a microorganism being capable of hydroxylating vitamin D compound ... | 12/12/1995 |
| 5444087 | Manumycin compounds Manumycin C, Manumycin D and Manumycin E, obtainable by cultivation of a strain of Streptomyces sp. A.T.C.C. No. 55484, oxidized derivatives thereof and salts and prodrugs of these compounds. The novel compounds have antibacterial and antitumor activity.... | 08/22/1995 |
| 5431896 | Microbial immunoregulant Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection... | 07/11/1995 |
| 5407816 | Enhanced production of taxol and taxanes by cell cultures of taxus species This invention is directed to methods for the enhanced production and recovery of taxol and taxanes by cell cultures of Taxus species.... | 04/18/1995 |
| 5403728 | Microbial process for preparing mevinolin by a strain of aspergillus The invention refers to a new microbial process for preparing ଲ,δ-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid δ-lactone of formula (I) and ଲ,δ-dihydroxy-7-[1,2,6,7,8,8a-hexah... | 04/04/1995 |
| 5338845 | Aspergillus species, cyclic dimeric dipeptide derivative substance P antagonist biosynthetic products thereof, and process for preparation thereof A novel Aspergillus species, cyclic dimeric dipeptide derivatives which are biosynthetic products thereof and are useful as Substance P antagonists and therefore as analgesic and/or antiinflammatory agents, and a process for preparation of the biosyntheti... | 08/16/1994 |
| 5316939 | Microorganism belonging to the genus Rhodococcus, and process for producing sec-cedrenol and cedrenone A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of -cedrene, a process for producing sec-cedrenol comprising contacting a microorganism belonging to the genus Rhodoco... | 05/31/1994 |
| 5302522 | Process for the production of sec-cedrenol and cedrenone from -cedrene by rhodococcus A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of -cedrene, a process for producing sec-cedrenol comprising contacting a microorganism belonging to the genus Rhodoco... | 04/12/1994 |
| 5290698 | Streptoverticillium ferm P-10489 which produces antitumor agent BE-13793C A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of... | 03/01/1994 |
| 5248601 | Process for preparing L(-)-carnitine chloride A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2## wherein R is an alkyl group having from 1 to ... | 09/28/1993 |
| 5217885 | Antitumor substance BE-13793C A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of... | 06/08/1993 |
