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| Number | Title | Issue Date |
| 8148118 | Method of inducing chirality to epoxides using 2,3:4,6 di-O-isopropylidene-2-keto-L-gulonic acid monohydrate The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea... | 04/03/2012 |
| 7439045 | pH controlled fermentation process for pseudomonic acid production An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of ... | 10/21/2008 |
| 7405063 | Biooxidation capabilities of sp A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates. ... | 07/29/2008 |
| 7396667 | Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a re-polymerizable oligomer. A producing process of polylactic acid, wherein th... | 07/08/2008 |
| 7350331 | Method for producing metabolites from plants cultivated in soil-less medium A method for producing molecules from plants, characterized in that the plants are cultivated in soil-less conditions and are supplied with a nutrient solution and/or sprayed with a leaching liquid, the solution and/or the liquid being subsequently recovered and tre... | 04/01/2008 |
| 7326779 | Primers and method of detecting bacteria The first primer of the invention is a primer which, when used in PCR under appropriate conditions, serves to detectably amplify 16S rRNA-encoding DNAs of bacteria of the Escherichia, Salmonella and Vibrio genera, but when used in PCR under the same co... | 02/05/2008 |
| 7264951 | Enhanced production of taxol and taxanes by cell cultures of species This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, med... | 09/04/2007 |
| 7259268 | Method for purification of paclitaxel from paclitaxel-containing materials This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extr... | 08/21/2007 |
| 7238348 | Method of treatment of osteoporosis with compositions of red rice fermentation products Methods are disclosed for using red rice fermentation products for the treatment or prevention of osteoporosis and abnormal bone mass conditions. Particular Monascus strains yield fermentation products with the desired biological activities. ... | 07/03/2007 |
| 7238514 | Diterpene-producing unicellular organism The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synt... | 07/03/2007 |
| 7217558 | Microorganism producing 5'xanthylic acid The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5′-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 which is a mutant strain of Corynebacterium amm... | 05/15/2007 |
| 7202063 | Processes for the production of rhamnolipids A process for producing rhamnolipids involving culturing Pseudomonas chlororaphis strain NRRL B-30761 in a first aqueous culture medium containing about 0.3% NH4H2PO4, about 0.2% K2HPO4, about 0.2% carbon... | 04/10/2007 |
| 7198808 | Process for extracting compounds from plants The present invention provides a method for selectively extracting acidic and/or non-acidic compounds from natural material such as plant tissue. ... | 04/03/2007 |
| 7169591 | Preparation of enantio-specific epoxides A method for converting alkenes into epoxides and, particularly, to convert alkenes into enantio-specific epoxides by the use of enzymes which may be in their naturally-occuring (native) form or in mutated form, such as a native or mutated non-haem diiron-containing... | 01/30/2007 |
| 7141412 | Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding pyrrolidines, respectively, by use of a bacterium having hydroxylation activity... | 11/28/2006 |
| 7129067 | Method for producing lactone This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy ... | 10/31/2006 |
| 7105187 | Method for obtaining taxanes A method for obtaining a taxane by which a taxane is isolated from a growth medium, such as soil, in which a taxane-producing plant has grown. ... | 09/12/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7063977 | Enzymatic resolution of t-butyl taxane derivatives A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula wherein R1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting the mixture ... | 06/20/2006 |
| 7060477 | Epoxide hydrolases of origin The invention concerns proteins of fungal origin having an epoxide hydrolase activity, such as those obtained in essentially pure form by extraction from fungi cells, or by culturing in host cells transformed by a nucleotide sequence coding for said fungal proteins.... | 06/13/2006 |
| 7060471 | Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phe... | 06/13/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 7052886 | Process for the isolation of lovastatin The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic acid to lovastatin in a totally aqueous medium. ... | 05/30/2006 |
| 7045354 | Process for scaled-up production of recombinant proteins using transgenic plant suspension cultures The present invention relates to methods for semi-continuous culture of plant cells in a nutrient medium. The pH of the medium is monitored during the cell culture as a way of monitoring the expression of a product of interest by the cells. ... | 05/16/2006 |
| 7045554 | Method for improved Fischer-Tropsch catalyst stability and higher stable syngas conversion The present invention is generally related towards methods for preparing and using a more stable synthesis catalysts. In particular, the present invention is directed towards treating synthesis catalysts with low levels of oxygen to deactivate the smaller more unsta... | 05/16/2006 |
| 7034130 | Method for producing novel spinosyn derivatives The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns. ... | 04/25/2006 |
| 7033621 | Isoflavone compositions produced from legumes Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the aglucone form and a C2-C10 organic solve... | 04/25/2006 |
| 6992112 | Selective removal of oxygen from syngas The present invention is an improvement in the preparation of liquid hydrocarbons from natural gas/methane, oxygen and/or steam. In particular, the present invention relates to processes for the production of synthesis gas, reducing the oxygen concentration from the... | 01/31/2006 |
| 6956123 | Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to... | 10/18/2005 |
| 6951745 | Polyhydroxyalkanoate-containing structure and manufacturing method thereof A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base mater... | 10/04/2005 |
| 6946283 | Ginkgo biloba levopimaradiene synthase The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae... | 09/20/2005 |
| 6939978 | Production of taxol and taxanes A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar substances. The organic solvent extract of the biomass is adsorbed onto ... | 09/06/2005 |
| 6927047 | Manufacture and purification of mycophenolic acid The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation of Pencillium brevi-campactum, in a contained bioreactor under optimal fermentation parameters with its subsequent purification steps. | 08/09/2005 |
| 6924129 | Enzyme-catalyzed esterification of pendant carboxylic acid groups A method for enzymatically synthesizing a polymer by combining a preselected quantity of an enzyme, a first reactant selected from polymers with at least one carboxylic acid pendant group, a second reactant selected from alcohols, i.e., polyols, in a reaction vessel... | 08/02/2005 |
| 6905875 | Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good ... | 06/14/2005 |
| 6903225 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required... | 06/07/2005 |
| 6852315 | Epoxidation of carbon-carbon double bond with membrane bound peroxygenase A method has been discovered for the epoxidation of a compound having at least one carbon-carbon double bond, the method involves reacting a compound having at least one carbon-carbon double bond, a solvent, an oxidant, and membrane bound peroxygenase. Also discover... | 02/08/2005 |
| 6844174 | Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oi... | 01/18/2005 |
| 6828115 | Epoxide hydrolases from streptomyces A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting e... | 12/07/2004 |
| 6780620 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 08/24/2004 |
