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| Number | Title | Issue Date |
| 7803585 | Process for preparing 2-Hydroxy-4-Substituted Pyridines A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. ... | 09/28/2010 |
| 7727750 | Biocatalytic asymmetric reduction in preparation of (S)-N-[5-(1,2-dihydroxy-ethyl)-pyrazinyl]-2,2-dimethyl-propionamide The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino-[5-(1-hydroxy-2-hydroxy or halogen-ethyl)]-pyrazine derivatives of the formula wherein R is lower alkylcarbonyl or an amino p... | 06/01/2010 |
| 7723082 | Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polyn... | 05/25/2010 |
| 7691615 | Process for the production of piperidine derivatives with microorganisms The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R | 04/06/2010 |
| 7432089 | DNA encoding favin-adenine-dinucleotide-dependent-D-erythronate-4-phosphate-de-hydrogenase, pdxR, and microbial production of vitamin B The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti, which is involved in vitamin B6 biosynthesis, and a recombinant microorg... | 10/07/2008 |
| 7371547 | Process for producing vitamin B6 Disclosed is a mutant of a recombinant microorganism of the genus Sinorhizobium capable of producing vitamin B6 having a recombinant plasmid with pdxJ gene that acquired histidine requirement of glycine resistance, or its combination thereof. ... | 05/13/2008 |
| 7297800 | Process of producing glutamate derivatives The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzy... | 11/20/2007 |
| 7241601 | Process for the preparation of Fexofenadine A process for the preparation of a compound of the formula by means of bioconversion with a microorganism culture of a compound of the formula ... | 07/10/2007 |
| 7232908 | Process for the production of piperidine derivatives with microorganisms The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products.... | 06/19/2007 |
| 7192729 | Methods for assaying homocysteine The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay methods that employ, mutant SAH hydrolase having binding affinity for Hcy, ... | 03/20/2007 |
| 7164025 | Manufacture of single isomer methylphenidate The present invention pertains to a process for obtaining a single enantiomer, d or l, of threo-methylphenidate, comprising resolution of a mixture of the enantiomers; racemisation of the unwanted enantiomer, to give a mixture of all four stereoisomers; and separati... | 01/16/2007 |
| 7153675 | Process for the preparation of substituted carboxylic esters A process for the preparation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by enzymatic hydrolysis, comprising the steps: a) enzymatic hydrolysis of racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters in aqueous and alkaline medium in the presence of an est... | 12/26/2006 |
| 7141573 | Polypharmacophoric agents One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, ... | 11/28/2006 |
| 7129067 | Method for producing lactone This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy ... | 10/31/2006 |
| 7115631 | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invent... | 10/03/2006 |
| 7078195 | Antibiotics AA-896 This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-8... | 07/18/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6946269 | Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same. ... | 09/20/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6919199 | Microbes and methods for remediation The present invention provides methods of using a microbe containing a polypeptide that degrades, preferably detoxifies, a compound that is present in the environment. Preferably, the polypeptide is a hydrolase and the compound is at least one s-triazine. The presen... | 07/19/2005 |
| 6780635 | Process for the preparation of optically active azabicyclo heptanone derivatives The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single enanotiomer of lactam (III) and the corresponding ring opened compound of... | 08/24/2004 |
| 6780634 | Method for producing (1R,4S)-2-azabicyclo[2.2.1]-hept-5-en-3-on derivatives A biotechnological method is described for preparing compounds of the general formulas wherein R1 is acyl or acyloxy and R2 is a hydrogen atom or C1-10 alkyl, comprising the conversion of... | 08/24/2004 |
| 6770463 | Process for the preparation of chiral isofluoroenes There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention. ... | 08/03/2004 |
| 6689587 | Polynucleotides encoding the nadC gene and methods of producing nicotinic acid or nicotinic acid derivatives The present invention relates to polynucleotides corresponding to the nadC gene and which encode the nicotinate nucleotide pyrophosphorylase protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucle... | 02/10/2004 |
| 6686182 | Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.... | 02/03/2004 |
| 6673582 | Microbes and methods for remediation The present invention provides methods of using a microbe containing a polypeptide that degrades, preferably detoxifies, a compound that is present in the environment. Preferably, the polypeptide is a hydrolase and the compound is at least one s-triazine.... | 01/06/2004 |
| 6613907 | Process for the production of piperidine derivatives with microorganisms The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: ##STR1## wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1... | 09/02/2003 |
| 6558931 | Process for the preparation of Fexofenadine The invention concerns a method for preparing Fexofenadine from Terfenadine by a bioconversion process using Absidia corymbifera LCP 63-1800 or Stepromyces platensis NRRL 2364 strain.... | 05/06/2003 |
| 6489147 | Gene for adenylate cyclase and its use A gene which contains the nucleotide sequence shown in SEQ ID NO:1 from nucleotide 671 to nucleotide 6295 or a nucleotide sequence which can be obtained therefrom by substitution, insertion or deletion of up to 30%, preferably up to 10%, particularly pref... | 12/03/2002 |
| 6451587 | Microbial asymmetric reduction of 2-chloro-1-[-6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone The present invention relates to microbial processes for carrying out the asymmetric reduction of a ketone to an alcohol, which comprises: contacting the ketone with a microorganism, or an enzyme reduction system capable of accomplishing the subject reduc... | 09/17/2002 |
| 6444450 | Large-scale production of polyphenols or polyaromatic amines using enzyme-mediated reactions A process for large-scale, low cost, batch or continuous production of polyphenols using enzyme-mediated reactions and methods for recycling non-consumed reactants.... | 09/03/2002 |
| 6416979 | 5-substituted picolinic acid compounds production by Marasmiellus sp The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 and R2 are independently H, C2 -C6 acyl or halo-subst... | 07/09/2002 |
| 6410265 | Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention f... | 06/25/2002 |
| 6406912 | Method for enzymatic enantiomer-separation of 3(r)- and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridi ne or its carboxylic acid esters The invention relates to a method for producing optically pure compounds of 3(R)- and 3(S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridi ne or its carboxylic acid esters by reacting the enantiomer mixtures stereoselectively, us... | 06/18/2002 |
| 6387667 | Process for producing cytidine diphosphate choline A process for producing cytidine diphosphate choline is provided. The process comprises carrying out an enzymatic reaction using microorganisms having the enzyme activities of cytidine-5'-triphosphate synthetase (pyrG), cholinephosphate cytidylyltransfera... | 05/14/2002 |
| 6361979 | Microbial conversion of 2-methylquinoxaline The present invention relates to processes for the microbial oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid which comprise contacting 2-methylquinoxaline with a microorganism, or a suitable mutant thereof, and incubating the resulting mi... | 03/26/2002 |
| 6284522 | Isolated and purified DNA molecule and protein for the degradation of triazine compounds An isolated and purified DNA molecule, and an isolated and purified protein, that are involved in the degradation of s-triazine compounds (e.g., atrazine) are provided. A method for the purification of this protein is also provided.... | 09/04/2001 |
| 6268183 | Method of purifying thuringiensin The invention discloses a two-step process for recovery of thuringiensin, comprising adsorbing the thuringiensin from fermentation broth by calcium silicate, and dissociating the thuringiensin by dibasic sodium phosphate. The resulting thuringiensin can b... | 07/31/2001 |
| 6248571 | Method of producing dihydroxypyrimidine derivatives A process for the preparation of dihydroxypyrimidine derivatives of the general formula: ##STR1## in which R1 and R2 are identical or different and are a hydrogen atom, aryl group, or a C1 -C4 -alkyl group or an... | 06/19/2001 |
