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| Number | Title | Issue Date |
| 8183019 | Method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis o... | 05/22/2012 |
| 8153405 | Products and methods for in vivo secretion of monatin Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and m... | 04/10/2012 |
| 8133704 | Biological synthesis of difunctional alkanes from carbohydrate feedstocks Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. M... | 03/13/2012 |
| 8119375 | Method for the production of ramipril An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method. ... | 02/21/2012 |
| 8105807 | Carbamoylglycine derivatives The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present inventio... | 01/31/2012 |
| 8076108 | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(i... | 12/13/2011 |
| 8043837 | Aldolases, nucleic acids encoding them and methods for making and using them This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypep... | 10/25/2011 |
| 7888081 | Methods and systems for increasing production of equilibrium reactions Methods and systems for increasing the production of equilibrium reactions are described. In some embodiments, a method comprises removing enzymes from a reaction mixture once equilibrium is achieved, selectively re-adding enzymes and reactants for driving the produ... | 02/15/2011 |
| 7582455 | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(i... | 09/01/2009 |
| 7572607 | Polypeptides and biosynthetic pathways for the production of monatin and its precursors Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-h... | 08/11/2009 |
| 7534591 | Bengamide derivatives, process for preparing them, and their use The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, t... | 05/19/2009 |
| 7432100 | Variant aldolase and processes for producing an optically active IHOG and an optically active monatin using the same The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG (4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid: IHOG), a process for producing an optically active IHOG using the same, and a process for producing an optically act... | 10/07/2008 |
| 7405070 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is select... | 07/29/2008 |
| 7371549 | Aldolase, and method for producing optically active IHOG and monatin The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As ... | 05/13/2008 |
| 7358374 | Purified racemic lasofoxifene and purified lasofoxifene D-tartrate and a method for effective purification of racemic lasofoxifene A method for removing impurities from racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol and purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol useful as an estrogen agonist/antagon... | 04/15/2008 |
| 7354746 | Method for producing optically active IHOG and monatin The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and an aldolase which can be used in the... | 04/08/2008 |
| 7351567 | Enzymatic resolution of selective estrogen receptor modulators The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist. ... | 04/01/2008 |
| 7300921 | Polyene polyketides and methods of production Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant... | 11/27/2007 |
| 7294493 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 11/13/2007 |
| 7241599 | Aldolase, and method for producing optically active IHOG and monatin The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As ... | 07/10/2007 |
| 7229803 | Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing c... | 06/12/2007 |
| 7223573 | Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process. ... | 05/29/2007 |
| 7220562 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either... | 05/22/2007 |
| 7196039 | Methods of reducing fluid loss in a wellbore servicing fluid Methods of reducing the fluid loss from a wellbore servicing fluid include combining a terpolymer with the wellbore servicing fluid to reduce the fluid loss from the fluid, followed by displacing the fluid into a wellbore. In an embodiment, the following monomers ar... | 03/27/2007 |
| 7135556 | NPC1L1 (NPC3) and methods of use thereof We claim an isolated polypeptide having ability of binding with cholesterol. Said polypeptide is useful for investigating regulation of intestinal cholesterol absorption and cholesterol levels. Also, we claim a composition comprising said polypeptide bound to choles... | 11/14/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 6962794 | Application of glucose transport mutants for production of aromatic pathway compounds This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts−/glucose+. Such host cells... | 11/08/2005 |
| 6953679 | Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 10/11/2005 |
| 6953678 | Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula R... | 10/11/2005 |
| 6936445 | Enzyme preparation and method of using the same There is disclosed are an enzyme preparation characterized by a polymer carrier having fine pores with average radius of 200-500 Å and the enzyme is capable of converting an N-substituted cyclic imino ester into an (S)-N-substituted cyclic imino acid, thereby an (... | 08/30/2005 |
| 6908752 | Process for the preparation of the enant iomeric forms of 2-substituted 2- (2, 5-dioxoimidazolidin-1yl) -acetic acid derivatives The present invention relates to a process for the preparation of the enantiomeric forms of 2-substituted 2-(2,5-dioxoimidazolidin-1-yl)acetic acid derivatives of the formula I, wherein R1, R2 and... | 06/21/2005 |
| 6906202 | Purified racemic lasofoxifene and purified lasofoxifene D-tartrate and a method for effective purification of racemic lasofoxifene A method for removing impurities from racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol and purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol useful as an estrogen agonist/antagon... | 06/14/2005 |
| 6905849 | Process for preparing clavam derivatives by using polypeptides having β-lactam synthetase activity The present invention relates to a new process for the synthesis of clavam compounds, in particular clavulanic acid. In one aspect, the invention relates to Streptomyces clavuligerus β-lactam synthetase polypeptide sand Streptomyces clavuligerus β-la... | 06/14/2005 |
| 6780620 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 08/24/2004 |
| 6642391 | Amycomycin, a process for its production and its use as a pharmaceutical A compound named Amycomycin of the formula: ##STR1## is described, as well as its pharmaceutically acceptable salts and derivatives, in all their stereoisomeric and tautomeric forms. The compound is obtained by growing the microorganism Amycolatopsis spec... | 11/04/2003 |
| 6638758 | Process for the enzymatic resolution of lactams A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the cor... | 10/28/2003 |
| 6635455 | Process for producing pyrrole-2-carboxylic acid A process for producing pyrrole-2-carboxylic acid which comprises the steps of: allowing a microorganism that is derived from the genus Serratia, is capable of catalyzing decarboxylation of pyrrole-2-carboxylic acid, and is capable of catalyzing the s... | 10/21/2003 |
| 6632659 | Apparatus and method for UV oxidation and microbiological decomposition of organic waste air The invention discloses an apparatus and a method for UV oxidation and microbiological decomposition of organic waste air. The invention provides an integrated system consisting of UV oxidation as a pretreatment process and biofiltration and biotrickling ... | 10/14/2003 |
| 6617451 | Enantioselective acylation of cis racemic azetidinones Cis-ଲ-lactam compounds having structure (II) are described herein which are prepared by enantioselective acylation of the free amine in the presence of Penicillin G Amidase. ##STR1##... | 09/09/2003 |
| 6613550 | Microbial process for preparation of optically active 3-hydroxypyrrolidine derivatives The present invention is directed to a process for the production of compounds of the formula: ##STR1## from a compound of the formula ##STR2## comprising hydroxylating a compound of the formula I in the presence of an enzyme produced by a mi... | 09/02/2003 |
