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| Number | Title | Issue Date |
| 8183018 | Process for producing of epoxy-containing (meth)acrylic esters, using lipases A process for preparing (meth)acrylic esters (F) of alcohols (A) having at least one epoxy group, in which at least one alcohol (A) having at least one epoxy group is esterified with (meth)acrylic acid (S) or is transesterified with at least one (meth)acrylic ester ... | 05/22/2012 |
| 8067212 | strain for high yield of tetramethylpyrazine This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacter... | 11/29/2011 |
| 7989189 | Mutant GTP cyclohydrolase II enzymes The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors.... | 08/02/2011 |
| 7888080 | Enzymatic reduction for producing optically active alcohols A process for preparing optically active alkanols of the formula I in which n is an integer from 0 to 5; Cyc is an optionally substituted, mono- or polynuclear, sat... | 02/15/2011 |
| 7556948 | Method for producing crystallized pleuromutilins Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. ... | 07/07/2009 |
| 7507560 | Enzymatic production of macrocyclic amide oligomers Hydrolytic enzymes capable of catalyzing amidation reactions can be used to produce cyclic amide oligomers from diesters and diamines. The cyclic amide oligomers are useful for the production of higher molecular weight polyamides. ... | 03/24/2009 |
| 7439045 | pH controlled fermentation process for pseudomonic acid production An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of ... | 10/21/2008 |
| 7432102 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, ther... | 10/07/2008 |
| 7427496 | Anti-cancer compounds The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers. ... | 09/23/2008 |
| 7414069 | Antituberculosis compounds, Hirsutellones A, B, and C Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against Mycobacterium tube... | 08/19/2008 |
| 7378268 | Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis o... | 05/27/2008 |
| 7375230 | Fermentation and purification of migrastatin and analog Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells. ... | 05/20/2008 |
| 7358233 | Tetronic acid derivative The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) show... | 04/15/2008 |
| 7351569 | Aldolase and production process of substituted α-keto acids 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erw... | 04/01/2008 |
| 7300779 | Preparation of a granule containing protein, corn starch and sugar layered on an inert particle Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an... | 11/27/2007 |
| 7267974 | Polyhydroxyalkanoate synthesizing microorganism and process of producing polyhydroxyalkanoate using the same Microorganisms showing higher productivity of unusual-polyhydroxyalkanoate (PHA) than ever by using an inexpensive substrate or under specific conditions are obtained from wild strains and mutant strains. The microorganisms are cultured with such substrates to synth... | 09/11/2007 |
| 7253206 | Phenalenone derivatives, processes for preparation and use thereof The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, ... | 08/07/2007 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7235396 | Bacterium for producing polyhydroxyalkanoate having polyhydroxyalkanoate depolymerase gene disrupted and method for producing polyhydroxyalkanoate using the same The objective of the present invention is to provide a bacterium for producing polyhydroxyalkanoate with improved productivity. To achieve above objective, the gene coding for the polyhydroxyalkanoate depolymerase of the bacterium for producing polyhydroxyalkanoate ... | 06/26/2007 |
| 7229803 | Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing c... | 06/12/2007 |
| 7169591 | Preparation of enantio-specific epoxides A method for converting alkenes into epoxides and, particularly, to convert alkenes into enantio-specific epoxides by the use of enzymes which may be in their naturally-occuring (native) form or in mutated form, such as a native or mutated non-haem diiron-containing... | 01/30/2007 |
| 7090999 | Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use The invention concerns methods for preparing pristinamycin IIA or IIB. ... | 08/15/2006 |
| 7083955 | Preparation of lactic acid from a pentose-containing substrate Cost-effective processes for producing lactic acid and/or lactate from pentose-containing substrates, such as xylose-containing substrates, are provided. In particular, processes for producing lactic acid and/or lactate include fermentation of pentoses, such as xylo... | 08/01/2006 |
| 7071168 | Anti-cancer compounds and methods related thereto The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n-X[Formula I] wherein X is a linker group having 2–5 functi... | 07/04/2006 |
| 7067544 | Epothilones C, D, E and F, preparation and compositions The present invention relates to epothilones C, D, E and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection. ... | 06/27/2006 |
| 7063977 | Enzymatic resolution of t-butyl taxane derivatives A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula wherein R1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting the mixture ... | 06/20/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 7049107 | Method of producing phosphatidylserine A novel method of producing PS is described herein. The method first involves producing PLD enzyme through the use of enzyme-producing microorganisms. The PLD enzyme is reacted with a lecithin and source of serine to produce the phosphatidylserine (PS). The method d... | 05/23/2006 |
| 7022502 | Process for the biological production of L-pipecolic acid A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by t... | 04/04/2006 |
| 7018808 | Polyketides and their synthesis and use The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded ... | 03/28/2006 |
| 7015309 | Pyrrhocoricin-derived peptides, and methods of use thereof Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R2 SEQ ID NO: 1 or multimeri... | 03/21/2006 |
| 6998411 | 2-Methylheptylisonicotinate and process for production thereof The present invention relates to a novel antifungal antibacterial compound 2-methylheptylisonicotinate of formula 1 below obtained from natural sources and to a process for the isolation thereof. ... | 02/14/2006 |
| 6991925 | Fermentation of clavulanic acid at a controlled level of ammonia A method for the production of clavulanic acid by the fermentation of a clavulanic acid producing microorganism at a controlled level of at least 50 mg/l ammonia has been provided for. Under the application of these reaction conditions surprisingly high produ... | 01/31/2006 |
| 6984510 | Vitamin B-phosphate phosphatase A purified vitamin B6-phosphate phosphatase (VB6PP), having the following physico-chemical properties: a) Molecular weight: 29,000±5,000 (consisting of a monomer having a molecular weight of 29,000±5,000); b) Co-factor: Mn2+, Mg2+,... | 01/10/2006 |
| 6972335 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/06/2005 |
| 6967085 | Flocculation of cell material A process of flocculating microbial cell material from a suspending medium which contains cell material, comprising adding to the suspending medium a first polymeric material which is cationic and has intrinsic viscosity of not more than 2 dl/g, and subsequently or ... | 11/22/2005 |
| 6953678 | Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula R... | 10/11/2005 |
| 6908752 | Process for the preparation of the enant iomeric forms of 2-substituted 2- (2, 5-dioxoimidazolidin-1yl) -acetic acid derivatives The present invention relates to a process for the preparation of the enantiomeric forms of 2-substituted 2-(2,5-dioxoimidazolidin-1-yl)acetic acid derivatives of the formula I, wherein R1, R2 and... | 06/21/2005 |
| 6909011 | Process for preparing protected, enantiomer-enriched cyanohydrins by in-situ derivatization A process for preparing protected, enantiomer-enriched cyanohydrins of the formula where R1 and R2 independently of one another can be an unsubstituted, monosubstituted or polysubstituted C1-C20-a... | 06/21/2005 |
| 6844173 | Strain of Streptomyces griseus A microorganism strain which is Streptomyces griseus FERM BP-5420 and processes for preparing compounds by cultivating such microorganism strain. ... | 01/18/2005 |
