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| Number | Title | Issue Date |
| 8119374 | Nucleotide sequences of coryneform bacteria coded for proteins participating in L-serine metabolism and method for microbial production of L-serine This invention relates to the nucleotide sequence of coryneform bacteria coding for proteins which are involved in L-serine metabolism with reduced and switched off L-serine dehydratase activity. The invention also relates to microorganisms used in methods for produ... | 02/21/2012 |
| 7919285 | DNA encoding novel enzyme having D-serine synthase activity, method of producing the enzyme and method of producing D-serine by using the same This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producin... | 04/05/2011 |
| 7851187 | Method of producing L-serine derivative and enzyme used therefore The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): (in the formula... | 12/14/2010 |
| 7572605 | Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or ... | 08/11/2009 |
| 7432085 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 10/07/2008 |
| 7432087 | Method for preparing (2S, 3R, 4S)-4-hydroxyisoleucine and analogues thereof The invention concerns a method for preparing a-amino acids of general formula (2S-1) wherein: the group R1 represents a hydrogen atom, a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or ... | 10/07/2008 |
| 7413884 | Immunological control of β-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using β-amyloid peptides which incorporate transition state analogs are also ... | 08/19/2008 |
| 7399617 | Method for producing an L-amino acid in an bacterium via altering expression levels of target proteins A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the... | 07/15/2008 |
| 7368276 | Polynucleotide constructs encoding aspartate kinase, aspartate-semialdehyde dehydrogenase, and dihydrodipicolinate reductase and related constructs, products, and methods The invention relates to production of lysine, and provides several isolated polynucleotide molecules useful for the production of L-lysine. One such polynucleotide encodes an aspartate kinase (ask), an aspartate-semialdehyde dehydrogenase (asd) and a dihydrodipicol... | 05/06/2008 |
| 7332309 | Process for the preparation of L-amino acids using strains of the enterobacteriaceae family which contain an enhanced sucC or sucD gene The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which a... | 02/19/2008 |
| 7323321 | Metabolic engineering of amino acid production The present invention is directed towards the fermentative production of amino acids, providing microorganisms, methods and processes useful therefor. Microorganisms of the invention are capable of converting glucose to amino acids other than L-isoleucine, L-leucine... | 01/29/2008 |
| 7311836 | Process for producing amino acid or salt thereof by column technique and production apparatus thereof According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so that a free amino acid is adsorbed on a carbonate-type anion exchange... | 12/25/2007 |
| 7300775 | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide ... | 11/27/2007 |
| 7300777 | Feedback-resistant pyruvate carboxylase gene from corynebacterium The present invention relates to a mutated pyruvate carboxylase gene from Corynebacterium. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also rela... | 11/27/2007 |
| 7273920 | Controlling protein levels in eucaryotic organisms The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for... | 09/25/2007 |
| 7267967 | Nucleic acid encoding pyruvate carboxylase from coryneform glutamicum A pyruvate carboxylase gene having SEQ ID NO:1 as well as an amino acid sequence having SEQ ID NO:2 expressed by the pyruvate carboxylate gene are disclosed. Also disclosed is a method for microbial production of amino acids of the aspartate and/or glutamate family ... | 09/11/2007 |
| 7247721 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 07/24/2007 |
| 7241600 | Process for the preparation of L-amino acids using strains of the enterobacteriaceae family The invention relates to a process for the preparation of L-amino acids, in particular L-threonine. ... | 07/10/2007 |
| 7238503 | Process for making fluoroleucine ethyl esters The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other reactions previously described. ... | 07/03/2007 |
| 7220572 | Method for producing L-leucine There is provided a method for producing L-leucine using bacterium belonging to the genus Escherichia, which produces L-valine, L-isoleucine and L-homoleucine in an amount of less than 1% of that of L-leucine produced due to inactivation of ilvE gene coding f... | 05/22/2007 |
| 7220561 | Processes for enhanced production of pantothenate The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasin... | 05/22/2007 |
| 7217544 | Method for the preparation of L-amino acids from D-amino acids The invention relates to recombinant microorganisms which, in comparison to the starting organism, have a higher concentration or activity of a D-amino acid oxidase, of an L-amino acid dehydrogenase, of an NADH cosubstrate regenerating enzyme and, if necessary, of a... | 05/15/2007 |
| 7211415 | Enterobacteriaceae strains over-expressing the yfiD gene for the fermentative production of L-amino acids The present invention relates to a process for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, wherein a) the yfiD ORF and/or the pflB gene or nucleotide sequences coding for the gene produ... | 05/01/2007 |
| 7192753 | Modified threonine deaminase Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to α-ketobutyrate. One or both of t... | 03/20/2007 |
| 7186532 | Process for producing D-serine The present invention relates to: a process for producing D-serine wherein a microbial cell which is modified to have a higher L-serine deaminase activity than Escherichia coli DH5α strain, a culture of said cell, or a processed product thereof is brought in... | 03/06/2007 |
| 7179623 | Method of producing amino acids using transformed with sucrose PTS genes Amino acids such as threonine, homoserine, isoleucine, lysine, valine and tryptophan are produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucrose non-assimilative strain belonging to the genus Escherichia ... | 02/20/2007 |
| 7160703 | Nucleotide sequences coding for the PtsI protein The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced. ... | 01/09/2007 |
| 7157251 | Process for the racemization of N-protected amino acids using racemase The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids. ... | 01/02/2007 |
| 7083952 | Nucleotide sequences coding for proteins involved in the biosynthesis of L-serine, an improved method for the microbial production of L-serine and a genetically modified microorganism suitable therefor The present invention relates to nucleotide sequences of coryneform bacteria, coding for proteins involved in the bio-synthesis of L-serine and to methods for the isolation thereof. The invention further relates to an improved method for the production of L-serine. ... | 08/01/2006 |
| 7067289 | Method for producing histidine by fermentation with The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-... | 06/27/2006 |
| 7037690 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 05/02/2006 |
| 7029896 | Phosphoserine phosphatase gene of coryneform bacteria The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open readin... | 04/18/2006 |
| 6960455 | Methods of making amino acids using E. coli transformed with csc genes An amino acid such as threonine, homoserine, isoleucine, lysine, valine and tryptophan is produced using a bacterium belonging to the genus Escherichia which has been constructed from sucorse non-assimilative strain belonging to the genus Escherichia a... | 11/01/2005 |
| 6953677 | Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial method of producing L-amino acids can be established with it, i... | 10/11/2005 |
| 6946588 | Nucleic acid encoding a modified threonine deaminase and methods of use Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to α-ketobutyrate. One or both of t... | 09/20/2005 |
| 6919190 | Regulation of carbon assimilation The present invention provides a method of increasing the productivity of a microorganism by improving the assimilation of carbon dioxide. Specifically, the invention provides a polypeptide having phosphoenolpyruvate carboxylase activity which does not require acety... | 07/19/2005 |
| 6916637 | Fermentation process for the preparation of L-amino acids using strains of the family Enterobacteriaceae The invention relates to a fermentation process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-am... | 07/12/2005 |
| 6902925 | Selection media for beauveriolide I or beauveriolide III and process for selectively producing these substances The present invention is a process for selective production of beauveriolide I substance or beauveriolide III substance, in which a beauveriolide producing microorganism strain FO-6979 or mutant thereof is cultured in a medium for fungi added with specific amino aci... | 06/07/2005 |
| 6902915 | Heat-stable D-aminoacylase The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms belonging ... | 06/07/2005 |
| 6887691 | DNA coding for protein which confers on bacterium Escherichia coli resistance to L-homoserine, and method for producing L-amino acids A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulat... | 05/03/2005 |
