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| Number | Title | Issue Date |
| 8158389 | Products and methods for in vivo secretion of monatin Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and m... | 04/17/2012 |
| 7935506 | Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L... | 05/03/2011 |
| 7888078 | Process for producing amino acids The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 μm to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, c... | 02/15/2011 |
| 7820415 | Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the ydiN gene or the ydiB gene or combination thereof The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of th... | 10/26/2010 |
| 7700328 | Method for producing an L-tyrosine over-producing bacterial strain An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and stron... | 04/20/2010 |
| 7638312 | mutant containing mutant genes related with tryptophan biosynthesis and production method of tryptophan by using the same The present invention relates to a Tryptophan-producing E. coli mutant strain CJ285 (KCCM-10534) containing single or multi mutant genes related with Tryptophan biosynthesis and production method of Tryptophan using the same. More particularly, DNA base seque... | 12/29/2009 |
| 7432085 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 10/07/2008 |
| 7381548 | Method for producing L-amino acid using bacterium of family having expression of gene attenuated The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the yafA ge... | 06/03/2008 |
| 7361490 | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino... | 04/22/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7338790 | Alleles of the gnd gene from coryneform bacteria The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes ... | 03/04/2008 |
| 7335496 | Method for producing target substance A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modif... | 02/26/2008 |
| 7332649 | Changing the fine chemical content in organisms by genetically modifying the shikimate pathway The present invention relates to a process for the production of fine chemicals, in particular vitamin E, vitamin K and/or ubiquinone by culturing organisms, in particular plants, whose shikimate pathway is genetically modified over that of the wild type, and to the... | 02/19/2008 |
| 7323328 | Obligately symbiotic thermophile SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The pre... | 01/29/2008 |
| 7311836 | Process for producing amino acid or salt thereof by column technique and production apparatus thereof According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so that a free amino acid is adsorbed on a carbonate-type anion exchange... | 12/25/2007 |
| 7312058 | Mutant serine acetyltransferase O-acetylserine, L-cysteine and sulphurous compounds derived therefrom may be produced using a bacterium belonging to the genus Escherichia which harbors a mutant feedback-resistant serine acetyltransferases in which the amino acid sequence corresponding to po... | 12/25/2007 |
| 7303900 | Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid using recombinant microorganisms Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redire... | 12/04/2007 |
| 7300775 | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide ... | 11/27/2007 |
| 7300776 | L-amino acid-producing bacterium and a method for producing L-amino acid An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group cons... | 11/27/2007 |
| 7288403 | Anthranilate synthase gene and method for increasing tryptophan production The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells o... | 10/30/2007 |
| 7282356 | D-aminoacylase mutants The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the D-aminoacylase derived from Alcaligenes denitrificans subsp. xylosoxyd... | 10/16/2007 |
| 7259003 | bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, and methods for producing an L-amino acid using same A method for producing an L-amino acid, such as L-phenylalanine or L-threonine, is provided using a bacterium belonging to the genus Escherichia, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the protein encod... | 08/21/2007 |
| 7256024 | Tyrissamycin antibiotic A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, part... | 08/14/2007 |
| 7223588 | Microorganisms and methods for overproduction of DAHP by cloned Pps gene Genetic elements comprising expression vectors and a gene coding for phosphoenol pyruvate synthase is utilized to enhance diversion of carbon resources into the common aromatic pathway and pathways branching therefrom. The overexpression of phosphoenol pyruvate synt... | 05/29/2007 |
| 7223572 | having enhanced dihydrodipicolinate synthase and/or aspartokinase activity for L-amino acid production An L-amino acid is produced by culturing a Methylophilus bacterium which can grow by using methanol as a main carbon source and has L-amino acid-producing ability, for example, a Methylophilus bacterium in which dihydrodipicolinate synthase activity an... | 05/29/2007 |
| 7220571 | strains which over-produce L-threonine and processes for the production of L-threonine by fermentation The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacterial strains and processes employing these strains for the fermentative production of amino acids such as threonine. ... | 05/22/2007 |
| 7214526 | Alleles of the mqo gene from coryneform bacteria The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes fo... | 05/08/2007 |
| 7192772 | Recombinant cells that highly express chromosomally-integrated heterologous gene Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased express... | 03/20/2007 |
| 7186531 | L-threonine producing bacterium belonging to the genus and method for producing L-threonine There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has been modified to enhance an activity of aspartate-β-semialdehyde dehydrogenase. ... | 03/06/2007 |
| 7179623 | Method of producing amino acids using transformed with sucrose PTS genes Amino acids such as threonine, homoserine, isoleucine, lysine, valine and tryptophan are produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucrose non-assimilative strain belonging to the genus Escherichia ... | 02/20/2007 |
| 7160703 | Nucleotide sequences coding for the PtsI protein The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced. ... | 01/09/2007 |
| 7157251 | Process for the racemization of N-protected amino acids using racemase The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids. ... | 01/02/2007 |
| 7129059 | Process for the preparation of compounds with enhanced optical purity A process for preparation of a compound with enhanced optical purity is disclosed wherein a mixture of the enantiomers of a chiral amine is brought into contact with an enzyme having peptide deformylase activity with a bivalent metal ion as a cofactor. ... | 10/31/2006 |
| 7115412 | Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthes... | 10/03/2006 |
| 7105326 | Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redire... | 09/12/2006 |
| 7098020 | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino... | 08/29/2006 |
| 7097999 | Method for producing target substance using microorganisms with reduced interactions between MalK and IIA The present invention describes a method for producing a target substance by utilizing a microorganism comprising culturing the microorganism in a medium, allowing the target substance to accumulate, and collecting the target substance from the medium. Also the micr... | 08/29/2006 |
| 7087728 | Carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the... | 08/08/2006 |
| 7074602 | Method for producing L-threonine An L-threonine-producing Escherichia coli strain and a method for producing the same are provided. The Escherchia coli strain contains chromosomal DNA with inactivated metJ gene. Therefore, expression repression of threonine biosynthesis genes by a met... | 07/11/2006 |
| 7067289 | Method for producing histidine by fermentation with The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-... | 06/27/2006 |
