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| Number | Title | Issue Date |
| 8119373 | Method for purifying histidine from a cell culture In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 420 μm or more and which ha... | 02/21/2012 |
| 8080396 | Microorganism producing an amino acid of the L-glutamic acid family and a method for producing the amino acid A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase α-ketoglutarate synthase activity. The... | 12/20/2011 |
| 8071339 | Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacter... | 12/06/2011 |
| 8058035 | Method for producing an L-amino acid A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and α-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or ce... | 11/15/2011 |
| 7888077 | Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kef... | 02/15/2011 |
| 7811798 | Method for producing an L-amino acid by fermentation using a bacterium having an enhanced ability to utilize glycerol The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to have glycerol kinase in which feedb... | 10/12/2010 |
| 7790422 | Method for producing basic substance A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein am... | 09/07/2010 |
| 7439036 | Process for producing optically active octahydro-1H-indole-2-carboxylic acid To provide an enzymatic resolution process for efficiently producing an optically active N-protected-octahydro-1H-indole-2-carboxylic acid denoted by the formula (2): by using an enzyme capable of asymmetrically hydrolyzing... | 10/21/2008 |
| 7432085 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 10/07/2008 |
| 7399617 | Method for producing an L-amino acid in an bacterium via altering expression levels of target proteins A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the... | 07/15/2008 |
| 7399618 | Method for producing L-histidine using bacteria of Enterobacteriaceae family A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene. ... | 07/15/2008 |
| 7311836 | Process for producing amino acid or salt thereof by column technique and production apparatus thereof According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so that a free amino acid is adsorbed on a carbonate-type anion exchange... | 12/25/2007 |
| 7300777 | Feedback-resistant pyruvate carboxylase gene from corynebacterium The present invention relates to a mutated pyruvate carboxylase gene from Corynebacterium. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also rela... | 11/27/2007 |
| 7300776 | L-amino acid-producing bacterium and a method for producing L-amino acid An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group cons... | 11/27/2007 |
| 7238501 | Process for producing trans-4-hydroxy-L-proline The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme sou... | 07/03/2007 |
| 7160703 | Nucleotide sequences coding for the PtsI protein The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced. ... | 01/09/2007 |
| 7157251 | Process for the racemization of N-protected amino acids using racemase The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids. ... | 01/02/2007 |
| 7067289 | Method for producing histidine by fermentation with The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-... | 06/27/2006 |
| 7037690 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 05/02/2006 |
| 6984514 | Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus Escherichia, which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid, L-proline or L-arginine, in a medium containing L-isoleucine, to produce a... | 01/10/2006 |
| 6979560 | Eschericha bacteria overexpressing the yahn gene for feedback-insensitive amino acid production A bacterium belonging to the genus Escherichia and having an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing an expression amount of an L-amino acid excretion protein, and a method for producing t... | 12/27/2005 |
| 6953677 | Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial method of producing L-amino acids can be established with it, i... | 10/11/2005 |
| 6808914 | Process for the preparation of L-amino acids by fermentation and nucleotide sequences coding for the accDA gene The invention relates to nucleotide sequences coding for the accDA gene and to a process for the preparation of L-amino acids, especially L-lysine, by fermentation using corynebacteria in which the accDA gene is amplified. ... | 10/26/2004 |
| 6767726 | Process for producing cis-3-hydroxy-L-proline An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of L-proline and to act on free L-proline in the presence of 2-ketoglut... | 07/27/2004 |
| 6706517 | Method for producing L-amino acids by fermentation The present invention provides an industrially efficient method for producing an L-amino acid useful as medicament, chemical agent, food material and feed additive, and the method comprising culturing in a medium a microorganism having an ability to produce the L-am... | 03/16/2004 |
| 6686181 | Method for the production of L-amino acids from their racemic N-aceytyl-D, L-derivatives by enzymatic racemate cleavage by means of isolated recombinant enzymes Process for the preparation of L -amino acids from their racemic N-acetyl-D,L derivatives by enzymatic resolution by means of isolated, recombinant enzymes A process for the preparation of proteinogenic or nonproteinogenic L-amino acids, in particular L-p... | 02/03/2004 |
| 6656710 | Process for the production of amino acids using racemase and acylase The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.... | 12/02/2003 |
| 6617140 | Process for producing trans-4-hydroxy-L-proline Provided is an industrially applicable process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an... | 09/09/2003 |
| 6551803 | Method for purification of amino acid containing solutions by electrodialysis A process is described for purifying an amino acid-containing solution by means of electrodialysis, wherein an amino acid-containing solution is employed which is obtained from the fermentation for producing at least one amino acid.... | 04/22/2003 |
| 6413748 | Process for producing CIS-3-hydroxy-L-proline An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source w... | 07/02/2002 |
| 6365381 | Method for producing optically active compound The present invention provides a method for industrially advantageously producing (S)-4-hydroxy-2-ketoglutaric acid and for producing compounds which are formed by biosynthesis from the precursor (S)-4-hydroxy-2-ketoglutaric acid, for example, for produci... | 04/02/2002 |
| 6344347 | Method for producing L-amino acids by fermentation The present invention provides an industrially efficient method for producing an L-amino acid useful as medicament, chemical agent, food material and feed additive, and the method comprising culturing in a medium a microorganism having an ability to produ... | 02/05/2002 |
| 6238895 | Production of aspartic and malic acids with microbacterium The use of strains of the genus Microbacterium for the production of organic acids or amino acids by the enzymatic conversion of a fumaric acid to the organic acid or amino acid desired, as well as methods for such use and the conversion solution produced... | 05/29/2001 |
| 6207427 | Method for producing optically active compound The present invention provides a method for industrially advantageously producing (S)-4-hydroxy-2-ketoglutaric acid and for producing compounds which are formed by biosynthesis from the precursor (S)-4-hydroxy-2-ketoglutaric acid, for example, for produci... | 03/27/2001 |
| 6204050 | Producing diastereomers of 4-hydroxyproline using 4-hp epimerase from Serratia marcescens or Acinetobacter baumanni The present invention relates to two novel microorganisms, Acinetobacter baumanni WT-50/50-4A (ATCC 202144) and Serratia marcescens WT-L-4A1(RED) (ATCC 202145) characterized by 4-hydroxyproline epimerase activity. The compounds trans-4-hydroxy-L-proline (... | 03/20/2001 |
| 6171829 | Physiologically active substance PF1191 and process for producing the same A substance PF1191 having an inhibitory activity to kainic acid toxicity represented by the following formula (I) which is obtained by incubating a fungus belonging to the genus Eupenicillium and isolating the product thus produced from the culture by sol... | 01/09/2001 |
| 6143552 | Process for producing L-amino acids by fermentation The present invention provides a process for producing an L-amino acid which comprises culturing in a nutrient medium a microorganism which is capable of producing the L-amino acid and which can not grow in a synthetic medium containing said L-amino acid ... | 11/07/2000 |
| 6133018 | Enzymatic synthesis of chiral amines using -2-amino propane as amine donor 2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase i... | 10/17/2000 |
| 6083917 | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase Disclosed are methods and compositions for the identification, characterization and inhibition of mammalian protein farnesyltransferases, enzymes involved in the farnesylation of various cellular proteins, including cancer related ras proteins such as p21... | 07/04/2000 |
| 6063615 | Enzymatic acylation of amino acid esters using a carboxylic acid ester substituted with oxygen on the alpha carbon Disclosed is a process for preparing acylated amino esters and a process for preparing optically active amino esters from racemic amino esters with a carboxylic ester as acylating agent, whose acid component has a halogen, nitrogen, oxygen or sulfur atom ... | 05/16/2000 |
