Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7141385 | Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectiv... | 11/28/2006 |
| 7064823 | Consumable tube for use with a flow cytometry-based hematology system The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cel... | 06/20/2006 |
| 7056713 | Urate oxidase The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modifie... | 06/06/2006 |
| 7026150 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 04/11/2006 |
| 6913915 | PEG-modified uricase The present invention is directed to uricase modified with polyethylene glycol and to methods of treating different illnesses characterized by increased circulating uric acid levels, including but not limited to, hyperuricemia and tumor lysis syndrome. ... | 07/05/2005 |
| 6872517 | Early diagnosis of cancerous and precancerous conditions by leakage of signature peptides and carbohydrates into the bloodstream The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a biological sample obtained from the gastrointestinal tract. ... | 03/29/2005 |
| 6753159 | Uric acid assay device with stabilized uricase reagent composition The invention provides an enzyme-based device and process for manufacture of the device in a shelf-stable form. The device consists of a dry phase test strip useful in detecting the presence and concentration of uric acid in a liquid sample (such as urine) and has a... | 06/22/2004 |
| 6689618 | Method and test strip of detecting oxidizing adulterant in urine A single reagent system and a method to detect and measure oxidizing adulterants in bodily fluid being screened for drugs of abuse are disclosed. The system comprising a strip containing 0.05 to 0.2 micromole/25 sq. mm. of a benzidine derivative and is us... | 02/10/2004 |
| 6682937 | Threshold glucose detection in urine Methods are provided for glucose detection and quantification in urine. The methods include selecting a test device comprising a matrix impregnated with a chromogenic indicator mixture, locating the test device to promote incidental contact of same with a... | 01/27/2004 |
| 6599474 | Threshold glucose detection in urine The present invention is directed to a reagent composition for use in detection and quantification of glucose in urine comprising a first chromogenic indicator reagent combination capable of color development to indicate the presence of a lower concentrat... | 07/29/2003 |
| 6455261 | Diagnostic assay using microperoxidase A method for determining the presence and/or the amount of an analyte in a sample which method comprises contacting the sample containing the analyte with a peroxidatively-active material to produce a peroxide, a substance capable of producing a detectabl... | 09/24/2002 |
| 6051389 | Enzyme sensor The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte in a test fluid. The sensor has at least one enzyme layer comprising an immobilized enzyme for which the analyte is a substrate. The immobilized en... | 04/18/2000 |
| 6030800 | Urine cancer test A urine test for cancer is disclosed for the detection of a broad spectrum of cancers in which the specimen of urine from the subject to be tested is placed into a test tube, a concentrated acid is added to the specimen and the resulting mixture is heated... | 02/29/2000 |
| 5935805 | Measurement of bilirubin albumin binding The present invention is directed to the determination of unconjugated and unbound bilirubin in a sample.... | 08/10/1999 |
| 5897993 | Method of determining the number of bacteria quickly and a device for determining the number of bacteria A method of determining the number of bacteria in a sample which involves introducing a sample containing bacteria into a tubular filtering vessel holding therein a hydrophobic filter for bacterial detection, a coloring composition is disposed on the side... | 04/27/1999 |
| 5888755 | Method of determining the amount of cholesterol in a high-density lipoprotein Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase in the presence of a reagent ... | 03/30/1999 |
| 5863746 | Method of measuring bilirubin An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that re... | 01/26/1999 |
| 5849474 | Diagnosis of preeclampsia in mammals An improved method of diagnosing preeclampsia comprising the steps of a. collecting blood from a pregnant female mammal; and b. detecting in said blood significantly elevated levels of at least one substance selected from the group consisting of: (1) a hemoglobin v... | 12/15/1998 |
| 5783407 | Method of measuring bilirubin An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that re... | 07/21/1998 |
| 5691159 | Method of determining the amount of cholesterol in a high-density lipoprotein Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase in the presence of a reagent ... | 11/25/1997 |
| 5654152 | Method of measuring enzyme activity by using a column having an immobilized substrate Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a support and a substrate that can be recognized by the enz... | 08/05/1997 |
| 5595867 | Method and kit for enzymatically determining the pH of a specimen The present invention concerns a method of enzymatically determining the pH of a specimen (e.g., a solution or a biological fluid) and a kit for conducting the method. The present method involves mixing (1) a specimen with (2) an enzyme and (3) one or mor... | 01/21/1997 |
| 5593851 | Test kid for the rapid detection of helicobacter pylori in gastric biopsy tissue A test kit for the rapid detection of the bacteria Helicobacter pylori in gastric biopsy tissue to diagnose gastric disease is described which includes a chemical test composition for the bacteria, a tray-like means including means to visibly display the ... | 01/14/1997 |
| 5567581 | Method and kit for enzymatically determining the pH of a specimen The present invention concerns a method of enzymatically determining the pH of a specimen (e.g., a solution or a biological fluid) and a kit for conducting the method. The present method involves mixing (1) a specimen with (2) an enzyme and (3) one or mor... | 10/22/1996 |
| 5559003 | Assay method for biological components The method is directed to assaying for biological components in a sample comprising step (A) generating an oxidase substrate in the presence of an amphoteric surfactant and in the absence of ferrocyanide; (B) initially generating hydrogen peroxide through... | 09/24/1996 |
| 5556743 | Method for immobilizing dye on substrates A dye is covalently bound to a polymeric film, especially a polyhydric polymer, for assays and other purposes. The dye may be one which, when it comes into contact with hydrogen peroxide, changes color to indicate the presence of hydrogen peroxide. This d... | 09/17/1996 |
| 5527509 | Colorimetric enzymic analysis A colorimetric enzymic analytical test element comprises a support and a plurality of reaction zones incorporating a dried enzyme composition, dyestuff and reagent adapted to provide a substantial dosage independent colorimetric display when the concentra... | 06/18/1996 |
| 5470750 | Detection of appendicitis by measurement of orthohydroxyhippuric acid Appendicitis can be detected in human beings suspected of having appendicitis by determining a threshold level of 10 mg/liter of ς-hydroxyhippuric acid in the urine of such humans. This threshold level can be determined by qualitative, semiquantitative, ... | 11/28/1995 |
| 5453360 | Oxidative coupling dye for spectrophotometric quantitive analysis of analytes A dye couple, comprising 3-methyl-2-benzothiazolinone hydrazone (MBTH) and 8-anilino-l-naphthalenesulfonate (ANS), is used as an indicator in a reaction cascade producing a strong oxidizing agent, such as hydrogen peroxide or other peroxides or perborates... | 09/26/1995 |
| 5439801 | Test composition for the rapid detection of helicobacter pylori in gastric biopsy tissue An improved test composition for the diagnosis of gastric disease by detecting the presence of urease associated with H. pylori in a biopsy specimen is described in which the hydrolysis of urea by urease is detected by a combination of at least two dye in... | 08/08/1995 |
| 5391482 | Method and diagnostic agent for enzyme substrate stabilization using 1-arylsemicarbazides The present invention is concerned with the use of 1-arylsemicarbazides of the general formula: Ar--NH--NH--CON2 wherein Ar is an aryl radical optionally substituted by alkyl, alkoxy or halogen, for the stabilization of an enzyme substrate from whic... | 02/21/1995 |
| 5384248 | Process for measuring an analyte with an oxidase and an oxidizable color reagent and surfactants A substrate or an enzymatic activity in a body fluid can be measured accurately without influences of interfering substances such as bilirubin by reacting an oxidase corresponding to an analyte with the analyte or an oxidase corresponding to a substance p... | 01/24/1995 |
| 5369013 | Method, reagent mixture and kit for determining the presence of bacterial or somatic cells in urine A method, reagent mixture and test kit are provided for testing a urine sample for the presence of bacterial or somatic cells, by reacting a urine sample with a catalase-free alkaline protease enzyme and a detergent compatible therewith, so as to disrupt ... | 11/29/1994 |
| 5366868 | Multilayer analytical element for assaying fructosamine A multilayer analytical element for assaying fructosamine, having a liquid-impermeable support, a buffer-containing layer which contains a buffer having pH of 8 to 12 formed on the support, a tetrazolium salt containing layer which is formed on the buffer... | 11/22/1994 |
| 5356790 | Highly sensitive assay method for myo-inositol, composition for practicing same, novel myo-inositol dehydrogenase, and process for producing same Myo-inositol in a specimen is assayed by reacting a specimen containing myo-inositol with: a) myo-inositol dehydrogenase using a thio-NADP group or thio-NAD group and an NADP group or NAD group as coenzymes, and which catalyzes a reversible reaction formi... | 10/18/1994 |
| 5314804 | Test for Helicobacter pylori A rapid method and easy to use unitized test device is disclosed for determining the presence of Helicobacter pylori in a biological tissue specimen by detecting the presence of urease in the tissue. The system basically utilizes a multilayer test device ... | 05/24/1994 |
| 5288606 | Reagent for specific determination of fructosamine The present invention provides a process for the specific determination of the serum fructosamine content in blood or samples derived from blood by reaction with an appropriate color reagent and measurement of the color change thereby brought about, where... | 02/22/1994 |
| 5278047 | Method of analysis, reagent composition and use thereof for glucose determination A method, a reagent composition and the use thereof for quantitative determination of total glucose in undiluted whole blood are described. A sample of undiluted whole blood is contacted with a reagent composition which is in dry form and comprises: gluco... | 01/11/1994 |
| 5266472 | Stabilization of the enzyme urate oxidase in liquid form This invention relates to a process for stabilizing the enzyme urate oxidase (commonly known as uricase) in liquid form, and to the relative compositions which can then be obtained, with particular reference to compositions containing a Trinder reagent. A... | 11/30/1993 |
| 5264348 | Ascorbate interference-resistant composition, device and method of assaying for predetermined analyte A new and improved test device and method of determining the presence or concentration of a predetermined analyte, such as glucose, cholesterol or occult blood, in a test sample are disclosed. The test device includes a test pad comprising a suitable carr... | 11/23/1993 |
