Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8187799 | Stabilization of liquid solutions of recombinant protein for frozen storage The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a car... | 05/29/2012 |
| 8124329 | Hypothermic preservation of biological tissues and cells A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixtu... | 02/28/2012 |
| 8071281 | Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C,... | 12/06/2011 |
| 8071280 | Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C,... | 12/06/2011 |
| 8048618 | Method for preparing and preserving a natural allograft intervertebral disk for humans A natural spinal disk including adjacent vertebral structures is removed from a deceased donor, rinsed in normal saline, preserved in a cryopreservative solution, and then frozen by gradually decreasing the temperature using liquid nitrogen or similar method. The im... | 11/01/2011 |
| 7943293 | Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C,... | 05/17/2011 |
| 7935478 | Biological material and methods and solutions for preservation thereof A preservation solution for preserving a biological material at a low temperature including one or more polyphenols, and a method for preserving a biological material are provided. The method includes adding the preservation solution to a biological material, coolin... | 05/03/2011 |
| 7879539 | Improving the post-thaw survival of mammalian blastocyt or sperm by applying hydrostatic pressure prior to cryopreservation The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined... | 02/01/2011 |
| 7741018 | Advantageous vitrifiable cryoprotectant mixtures Disclosed herein are aqueous carrier solutions for cryoprotectants that are useful for a variety of cryoprotectant solutions for use with cells, tissues, and whole organs, said aqueous carrier solutions permitting antinucleators to be fully effective in vitrificatio... | 06/22/2010 |
| 7553612 | Method for cryopreserving microencapsulated living animal cells enclosed in immunoisolation membranes, such microencapsulated living animal cells in immunoisolation membranes, and biohybrid artificial organ modules using such microencapsulated living animal cells in immunoisolation membranes A method is disclosed for cryopreserving living animal cells in immunoisolation membranes, including: (1) cutting out a living organ from an animal, (2) digesting the cutout organ into the discrete living animal cells and separating the discrete cells, (3) suspendin... | 06/30/2009 |
| 7501231 | Methods and compositions for cryopreservation of dissociated primary animal cells The invention can be summarized as follows. The present invention provides cell culture compositions and cell cryopreservation compositions for culturing and cryopreserving enteric system (ENS) neurons and central nervous system (CNS) neurons. The present invention ... | 03/10/2009 |
| 7353658 | Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material ther... | 04/08/2008 |
| 7354702 | Processing tissue to produce a biopolymer scaffold for tissue engineering A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The process includes, but is not limited to, harvesting the tissue, optional... | 04/08/2008 |
| 7331186 | Changing the temperature of a liquid sample and a receptacle useful therefor Disclosed is a method of changing the temperature of a liquid sample, comprising: providing a receptacle having inner and outer walls defining an annular portion therebetween for receiving therein a liquid sample, inserting said liquid sample, at a first temperature... | 02/19/2008 |
| 7318998 | Tissue decellularization The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon ... | 01/15/2008 |
| 7316896 | Egg freezing and storing tool and method An egg freezing and storing instrument has an egg freezing and storing tube made of a liquid nitrogen-resistant material; and a metal cylindrical protection member for protecting the tube. The tube has a body part; and an egg-storing small-diameter part having an in... | 01/08/2008 |
| 7314755 | Preservation of eukaryotic cells using reversible pore formation A method is disclosed for reliably stabilizing eukaryotic cells that express the P2X7 receptor channel, particularly mammalian and other vertebrate cells, including human cells, for example mammalian macrophages, or hematopoietic stem cells, in order to i... | 01/01/2008 |
| 7304743 | Diffuse reflectance readhead A glucose monitoring system comprising a readhead positioned a predetermined distance from a sample aperture. The readhead comprises first and second LEDs adapted to emit intersecting paths of light. A beam splitter is positioned at the intersection of the light pat... | 12/04/2007 |
| 7272252 | Automated system for combining bright field and fluorescent microscopy A method and apparatus for automated analysis of transmitted and fluorescently labeled biological samples, wherein the apparatus automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. Once can... | 09/18/2007 |
| 7270946 | Method for treatment of cellular materials with sugars prior to preservation Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the cellular material to a preservation protocol, such as freezing, vitrificat... | 09/18/2007 |
| 7256040 | Method and apparatus for preparing monolayers of cells The invention concerns an apparatus for preparing monolayers of cells. The apparatus comprises a container (6) for a cryosubstitution system and an insert (1) for the container, the insert (1) having a surface (1a) and a plurality ... | 08/14/2007 |
| 7252988 | Straw for the conservation of small quantities of substances, in particular biological liquids A straw (1) for the conservation of small quantities of substances, in particular biological substances, having a segment of tube provided inside one end with a stopper including gel powder, characterized in that a proportion of the gel powder is replaced wit... | 08/07/2007 |
| 7250292 | Hypertonic reduction of chilling injury This invention relates generally to cryopreservation and a method for preventing injury caused by cooling and warming of tissue and for reducing the toxicity of vitrification solutions. The present method achieves reduction or elimination of injury by increasing the... | 07/31/2007 |
| 7228688 | Scaled down freezing and thawing system for biopharmaceuticals and biologics A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservatio... | 06/12/2007 |
| 7229820 | Apparatus and method for culturing and preserving tissue constructs A disclosure is made of various apparatus and methods for culturing and preserving cells and tissue in ways that minimize contamination potential, direct cells to reside in desired areas, allow uniform cell distribution during seeding, provide optimal growth conditi... | 06/12/2007 |
| 7214508 | Method for coarse purification of cell digests from microorganisms The present invention relates to the coarse clarification of lysed cell material from microorganisms and particularly to a method of obtaining nucleic acids. In certain embodiments, the present invention provides a method of coarsely clarifying cell lysate from micr... | 05/08/2007 |
| 7176022 | Directly injectable formulations which provide enhanced cryoprotection of cell products This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO ... | 02/13/2007 |
| 7157222 | Method of cryopreservation of tissues by vitrification A method for vitrification of a tissue or organ includes immersing the tissue or organ in increasing concentrations of cryoprotectant solution at a temperature greater than −15° C. to a cryoprotectant concentration sufficient for vitrification; cooling the tissue... | 01/02/2007 |
| 7153433 | Use of functionalized porous membranes or matrices for purification of nucleic acids and corresponding methods Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an ambient medium. The membrane is functionalized by deprotonated groups. | 12/26/2006 |
| 7153472 | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers This invention relates to formulations comprising biological samples preserved as dry glassy powders and hydrophobic carriers, the formulations being adapted for the long-term storage and delivery of the bioactive materials, in particular viral and bacterial vaccine... | 12/26/2006 |
| 7150999 | Process for filling microfluidic channels The present invention provides novel methods and devices for filling at least one microfluidic channel with a gas or with a degassed fluid. In particular the methods and devices of the invention are useful in completely filling substantially all areas of a microflui... | 12/19/2006 |
| 7138227 | Frozen spermatozoa compositions and uses thereof The present invention provides a composition for freezing or freeze-drying spermatozoa or sperm heads thereof, wherein the composition enables the spermatozoa or sperm heads thereof to maintain chromosome integrity at a temperature of about +4° C. to about −200°... | 11/21/2006 |
| 7137261 | Systems and methods for freezing, mixing and thawing biopharmaceutical material A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical materi... | 11/21/2006 |
| 7129035 | Method of preserving tissue This invention relates to the sterilization and preservation of tissue for storage. More specifically, the invention relates to a method of using a solution to form a preserved tissue. The solution includes a radical scavenger at a concentration believed to reduce t... | 10/31/2006 |
| 7112576 | Compositions and methods for cryopreservation of peripheral blood lymphocytes A composition and method for cryopreserving cells in a non-toxic medium is described. The composition and method provide cells for cell therapy and other in vivo applications. ... | 09/26/2006 |
| 7104074 | Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material ther... | 09/12/2006 |
| 7094601 | Microinjection of cryoprotectants for preservation of cells A preservation method for biological material having cell membranes includes microinjecting the cells with sugar; preparing the cells for storage; storing the biological material; and recovering the stored biological material from storage. The invention also feature... | 08/22/2006 |
| 7090974 | Ultrasound-mediated high-speed biological reaction and tissue processing Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used and the sample or tissue receives 0.1–200 W/cm2 of ultr... | 08/15/2006 |
| 7087370 | Kit for vitrifying specimens The present invention relates to systems for the vitrification of a biological specimen. The systems employ a transfer instrument such as a loop, containing a base medium that includes a cryoprotectant. The biological specimen which has undergone vitrification may b... | 08/08/2006 |
| 7029839 | Methods and solutions for storing donor organs A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium chan... | 04/18/2006 |
