Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 8142991 | Cyclic implant perfusion, cleaning and passivation process and implant produced thereby This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inac... | 03/27/2012 |
| 8084195 | Method of perfusing an organ with a solution comprising a peptide which inhibits protein kinase C βII The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C βII (PKC βII) and/or of protein kinase C ζ (PKC ζ) ... | 12/27/2011 |
| 8012677 | Evaluation and preservation solution An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof h... | 09/06/2011 |
| 7985536 | Method for regulating NO production in an isolated organ or tissue during warm perfusion An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed that employs a warm perfusion solution capable of altering the production of nitric oxide (NO) in an organ or tissue and supporting the metabolis... | 07/26/2011 |
| 7977042 | Composition and method for the restoration and preservation of transplant organs procured from DCD donors The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for... | 07/12/2011 |
| 7897327 | Method and apparatus for pressure control for maintaining viability of organs A method for controlling a pump for delivery of liquid to an organ over a series of fixed-length time intervals f, each interval f comprising a time t1 and a time t2 wherein t1+t2 equals the length of interval f. The metho... | 03/01/2011 |
| 7824848 | Apparatus and method for maintaining and/or restoring viability of organs An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusin... | 11/02/2010 |
| 7749693 | Method of determining that an organ is not suitable for transplantation and using it for testing substances An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusin... | 07/06/2010 |
| 7713686 | Organ preservation container and method An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is pro... | 05/11/2010 |
| 7670762 | Biocompatible tissue graft material for implant and method of making This invention provides an antigen-free and immunologically inert tissue graft material and methods of preparing and using these tissue graft materials. ... | 03/02/2010 |
| 7651835 | Method of timing pulsatile flow of normothermic perfusate to the heart The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. ... | 01/26/2010 |
| 7575856 | Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts. ... | 08/18/2009 |
| 7504201 | Method for perfusing an organ and for isolating cells from the organ An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusin... | 03/17/2009 |
| 7368109 | Monoclonal antibodies against leukocyte adhesion receptor β-chain, methods of producing these antibodies and use therefore Monoclonal antibodies and method for ameliorating an immune response disorder. The monoclonal antibodies are specific for an epitope present on the leukocyte adhesion receptor β-chain. ... | 05/06/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7354730 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 04/08/2008 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7338962 | Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us... | 03/04/2008 |
| 7335642 | Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A th... | 02/26/2008 |
| 7314880 | Cardioprotective delta opioid receptor agonists and methods of using same The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce ... | 01/01/2008 |
| 7310545 | Method and device to form a sensor using isolated cardiomyocytes A method and device are described to form a sensor using a cardiomyocyte by advancing a catheter into the tissue of interest, cardiac in the preferred embodiment, and using the catheter to ablate a cone- or a dome-shaped region to form an electrically isolated secti... | 12/18/2007 |
| 7297475 | Medicament injection kit and medicament injection method A medicament injection kit, for use in occluding a renal artery and a renal vein in a kidney and injecting a therapeutic medicament into the kidney so as to pressurize the kidney, includes: an artery catheter which includes a first balloon capable of occluding the r... | 11/20/2007 |
| 7288551 | Solution for the preservation of hearts The present invention is directed to preservation solutions for storing and perfusing a heart intended for transplantation to a patient requiring such implant. It was found that when cyclosporin is added to the preservation solution for to: (1) preserve the mitochon... | 10/30/2007 |
| 7285266 | Cell-polymer fiber compositions and uses thereof The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising p... | 10/23/2007 |
| 7255879 | Post-partum mammalian placenta, its use and placental stem cells therefrom The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood b... | 08/14/2007 |
| 7255983 | Evaluation and preservation solution An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof h... | 08/14/2007 |
| 7250292 | Hypertonic reduction of chilling injury This invention relates generally to cryopreservation and a method for preventing injury caused by cooling and warming of tissue and for reducing the toxicity of vitrification solutions. The present method achieves reduction or elimination of injury by increasing the... | 07/31/2007 |
| 7241754 | 2-Desmethyl ansamycin compounds 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents ... | 07/10/2007 |
| 7220538 | Composition for maintaining organ and cell viability The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs suc... | 05/22/2007 |
| 7220407 | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction The present invention relates to methods of using Granulocyte Colony Stimulating Factor (G-CSF) polypeptide in conjunction with reperfusion therapy in the treatment of acute myocardial infarction or other ischemic events. This treatment can be used alone or in combi... | 05/22/2007 |
| 7208580 | Atomic structure of the hemalbumin complex and its use in designing therapeutic compounds A high resolution structure of the hemalbumin binding complex is provided which includes the detailed atomic coordinates which reflect the binding site and the binding characteristics of the structure. This high resolution structure can be used in methods of determi... | 04/24/2007 |
| 7176015 | Organ preservation apparatus and methods This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascula... | 02/13/2007 |
| 7157221 | Processes for making protein hydrolysates from animal peptone and for preserving mucosa A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventi... | 01/02/2007 |
| 7156803 | Devices for controlling fluid flow through a medium A fluid flow system for preparing an implantable substrate is provided having a fluid permeable container that is capable of retaining a biocompatible, implantable substrate, and a driver mechanism for subjecting fluid to a constant force to induce a selected, contr... | 01/02/2007 |
| 7142910 | Methods of indirectly stimulating the vagus nerve with an electrical field Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs. ... | 11/28/2006 |
| 7060792 | Protection against ischemia and reperfusion injury A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduc... | 06/13/2006 |
| 7045279 | Isolated perfused heart preparation and method of use An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical de... | 05/16/2006 |
| 7041840 | Antioxidant triacylglycerols and lipid compositions A lipid composition includes triacylglycerols that include unsaturated fatty acids such as alpha linolenic acid and antioxidant moeities such as pyruvic acid. ... | 05/09/2006 |
| 7029839 | Methods and solutions for storing donor organs A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium chan... | 04/18/2006 |
| 7029838 | Prevascularized contructs for implantation to provide blood perfusion This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs followi... | 04/18/2006 |
