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| Number | Title | Issue Date |
| 8142990 | Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and... | 03/27/2012 |
| 8129102 | Method for harvesting and preparing porcine hearts for use in a cardiac surgical simulator A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery. ... | 03/06/2012 |
| 8110346 | Process for preserving tissues A process for preserving tissues is described which comprises transferring the tissues in a container and evacuating the container. ... | 02/07/2012 |
| 8092987 | Mucosa tissue preserved with heating and hydrogen peroxide or phosphoric acid A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventi... | 01/10/2012 |
| 8088568 | Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and... | 01/03/2012 |
| 8088567 | Human immortalised neural precursor cell line The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a n... | 01/03/2012 |
| 8067149 | Acellular dermal matrix and method of use thereof for grafting A method for processing and preserving an acellular collagen-based tissue matrix for transplantation is disclosed. The method includes the steps of processing biological tissues with a stabilizing solution to reduce procurement damage, treatment with a processing so... | 11/29/2011 |
| 8067150 | In-situ preservation (ISP) bridge method and solution for non-heart beating donors A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, ... | 11/29/2011 |
| 8029977 | Method for preserving organs or limbs using a composition containing a siloxane and a semifluorinated alkane and/or hydrofluoroether Use of a composition which contains at least one semifluorinated alkane compound and at least one liquid siloxane, wherein the composition is of a density in a range of 0.8 to 1.5 g/cm3, for preserving organs or limbs. ... | 10/04/2011 |
| 8021830 | Method for increasing plasma volume by administering a plasma expander comprising basic alpha keratose A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of; or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic al... | 09/20/2011 |
| 8017311 | Method for treatment of cellular materials with sugars prior to preservation Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the cellular material to a preservation protocol, such as freezing, vitrificat... | 09/13/2011 |
| 8017312 | Method for preserving cells, tissues or organs using a solution comprising alkyldiamine-beta-cyclodextrin A composition for protecting and/or preserving cells, tissues or organs, includes at least one cyclodextrin, preferably closely combined with an antioxidant. A process for producing this composition and its uses are also disclosed. ... | 09/13/2011 |
| 8007991 | Three-dimensional physiological matrices for oncological testing, and methods for their production and use Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiolog... | 08/30/2011 |
| 8007993 | Method for storage and perfusion of organs using a solution comprising L-carnitine and isovaleryl L-carnitine A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b)... | 08/30/2011 |
| 8007992 | Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C-Calcohol A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 ... | 08/30/2011 |
| 7989158 | Solution containing carnitine for the storage and perfusion of organs awaiting transplantation A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b)... | 08/02/2011 |
| 7989157 | Solution for storing bioprosthetic tissue used in a biological prosthesis A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and ... | 08/02/2011 |
| 7981596 | Tissue preservation with a salt solution isotonic with interstitial fluids The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. ... | 07/19/2011 |
| 7977041 | Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiolog... | 07/12/2011 |
| 7955788 | Bioprosthetic tissue preparation with synthetic hydrogels Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glut... | 06/07/2011 |
| 7955789 | Adhesion-preventing material and process for preventing adhesion An object of the present invention is to provide an adhesion-preventing material which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and produced with ease and has high practical uti... | 06/07/2011 |
| 7943292 | Physiologically acceptable aqueous solutions and methods for their use Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a h... | 05/17/2011 |
| 7927784 | Vascular lumen debulking catheters and methods A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly dispo... | 04/19/2011 |
| 7897326 | Peroxisome-proliferator activated receptor-alpha agonists for organ preservation Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ. ... | 03/01/2011 |
| 7892724 | Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be har... | 02/22/2011 |
| 7883841 | Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiolog... | 02/08/2011 |
| 7824847 | Tissue preservation method with polyoxyethylene/polyoxypropylene copolymer Tissue preservation media comprising a polyoxyethylene/polyoxypropylene copolymer are used to preserve tissues and organs for storage and transplantation. In particular embodiments, the polyoxyethylene/polyoxypropylene copolymer is Pluronic F68 or FLOCOR (CRL-5861; ... | 11/02/2010 |
| 7803522 | Elastin producing fibroblast formulations and methods of using the same The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration... | 09/28/2010 |
| 7781158 | Method of separating collagen from the various animal tissues for producing collagen solution and product using the same A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsi... | 08/24/2010 |
| 7749692 | Tissue preservation method comprising contacting tissue with a solution of nanobubbles and salt An object of the invention is to provide a tissue preservation solution that has excellent tissue-preserving ability and is useful in the field of medicine, medical experiment, etc. Thus, the invention relates to a tissue preservation solution including oxygen nanob... | 07/06/2010 |
| 7745105 | Method of preparing soft tissue for a biological scaffold by lyophilizing, heating and elastase treatment A method for preparing a scaffold material for use in the prosthesis therapy is disclosed. The method comprises (a) lyophilizing a segment of native soft tissue of mammalian origin, heating the lyophilized tissue at a temperature of 100-200° C., and incubating the ... | 06/29/2010 |
| 7736845 | Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor th... | 06/15/2010 |
| 7732125 | Bioartificial primarily vascularized tissue matrix, and bioartificial primarily vascularized tissue, method for the production and use of the same The invention relates to a bioartificial primarily vascularized tissue matrix, a bioartificial primarily vascularized tissue, a method for the production thereof and the use of the same. Said tissue matrix and bioartificial primarily vascularized tissue are obtained... | 06/08/2010 |
| 7687230 | Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, t... | 03/30/2010 |
| 7655391 | Method for shipping items in an aircraft A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas t... | 02/02/2010 |
| 7645568 | Xenograft heart valves The invention provides an article of manufacture comprising a substantially non-immunogenic heart valve xenograft for implantation into humans. The invention further provides methods for preparing a heart valve xenograft by removing at least a portion of a soft tiss... | 01/12/2010 |
| 7611830 | Device to lavage a blood vessel The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. The presen... | 11/03/2009 |
| 7604929 | Cellular compositions and methods for their preparation The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and th... | 10/20/2009 |
| 7601487 | Composition using HMW dextran and method for in vitro preservation of corneal tissues A corneal storage solution which maintains cell density and cell viability of corneas stored in vitro for a period of greater than four days up to about two weeks is provided. The solution contains a buffered, balanced, nutrient and electrolyte aqueous solution, at ... | 10/13/2009 |
| 7601488 | Hyaluronic acid oligosaccharide fractions and drugs containing the same A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administe... | 10/13/2009 |
