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| Number | Title | Issue Date |
| 8440390 | Method for ice-free cryopreservation of tissue Method for preserving tissue including immersing the tissue in a solution having a cryoprotectant concentration of at least 75% by weight, a cooling step where the tissue is cooled to a temperature between the glass transition temperature of the solution having a cr... | 05/14/2013 |
| 8415093 | Post-thaw survival of cryopreserved biological material by hydrostatic pressure challenge The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined... | 04/09/2013 |
| 8409793 | Method for preparing a sample A method for preparing a sample consisting of biological tissue in a solid matrix includes steps of: contacting the sample with a first compressed fluid stream wherein the matrix is soluble so as to extract the solid matrix, contacting the sample with a second compr... | 04/02/2013 |
| 8354221 | Methods and compositions for the preservation of cells and tissues Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be... | 01/15/2013 |
| 8349550 | Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interactio... | 01/08/2013 |
| 8343717 | Passive methods for anti-microbial biological meshes Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matri... | 01/01/2013 |
| 8323881 | Method of cell injection into biotissue and apparatus therefor A method of injecting cells into a biological tissue comprising thrusting injection needle (200) under microvibration into tissue (5) secured by suction to tissue suction means (210) and effecting injection of a cell suspension into the tissue t... | 12/04/2012 |
| 8318413 | Amniopunch and uses thereof A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of co... | 11/27/2012 |
| 8313893 | Method of decellularizing porcine cornea Disclosed is a method for processing porcine cornea using an aqueous NaCl solution and an aqueous trypsin/EDTA solution to decellularize enucleated porcine cornea. The porcine cornea processed by the method causes neither inflammation nor immune rejection. The porci... | 11/20/2012 |
| 8304181 | Method for ex-vivo organ care and for using lactate as an indication of donor organ status The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for ... | 11/06/2012 |
| 8293463 | Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and... | 10/23/2012 |
| 8293462 | Method of preserving early mammalian embryos by vitrification This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer th... | 10/23/2012 |
| 8288084 | Composition and method for flushing and cold/cryo preserving organs, tissues, and cells Materials and methods for preserving biological materials (e.g., organs, tissues, and cells) under cold or cryo conditions while reducing or minimizing damage to the materials. ... | 10/16/2012 |
| 8278031 | Increasing the viability of mammalian oocytes The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at t... | 10/02/2012 |
| 8236486 | Flush preservation solution Flush preservation solution for the preservation of cells in the absence of a blood supply comprising: v) water for injection; and vi) at least one saccharide such as a monosaccharide, disaccharide, trisaccharide, or polysaccharide and... | 08/07/2012 |
| 8211628 | Compositions and methods for tissue preservation Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of indu... | 07/03/2012 |
| 8142990 | Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and... | 03/27/2012 |
| 8129102 | Method for harvesting and preparing porcine hearts for use in a cardiac surgical simulator A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery. ... | 03/06/2012 |
| 8110346 | Process for preserving tissues A process for preserving tissues is described which comprises transferring the tissues in a container and evacuating the container. ... | 02/07/2012 |
| 8092987 | Mucosa tissue preserved with heating and hydrogen peroxide or phosphoric acid A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventi... | 01/10/2012 |
| 8088567 | Human immortalised neural precursor cell line The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a n... | 01/03/2012 |
| 8088568 | Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and... | 01/03/2012 |
| 8067150 | In-situ preservation (ISP) bridge method and solution for non-heart beating donors A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, ... | 11/29/2011 |
| 8067149 | Acellular dermal matrix and method of use thereof for grafting A method for processing and preserving an acellular collagen-based tissue matrix for transplantation is disclosed. The method includes the steps of processing biological tissues with a stabilizing solution to reduce procurement damage, treatment with a processing so... | 11/29/2011 |
| 8029977 | Method for preserving organs or limbs using a composition containing a siloxane and a semifluorinated alkane and/or hydrofluoroether Use of a composition which contains at least one semifluorinated alkane compound and at least one liquid siloxane, wherein the composition is of a density in a range of 0.8 to 1.5 g/cm3, for preserving organs or limbs. ... | 10/04/2011 |
| 8021830 | Method for increasing plasma volume by administering a plasma expander comprising basic alpha keratose A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of; or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic al... | 09/20/2011 |
| 8017312 | Method for preserving cells, tissues or organs using a solution comprising alkyldiamine-beta-cyclodextrin A composition for protecting and/or preserving cells, tissues or organs, includes at least one cyclodextrin, preferably closely combined with an antioxidant. A process for producing this composition and its uses are also disclosed. ... | 09/13/2011 |
| 8017311 | Method for treatment of cellular materials with sugars prior to preservation Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the cellular material to a preservation protocol, such as freezing, vitrificat... | 09/13/2011 |
| 8007991 | Three-dimensional physiological matrices for oncological testing, and methods for their production and use Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiolog... | 08/30/2011 |
| 8007993 | Method for storage and perfusion of organs using a solution comprising L-carnitine and isovaleryl L-carnitine A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b)... | 08/30/2011 |
| 8007992 | Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C-Calcohol A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 ... | 08/30/2011 |
| 7989158 | Solution containing carnitine for the storage and perfusion of organs awaiting transplantation A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b)... | 08/02/2011 |
| 7989157 | Solution for storing bioprosthetic tissue used in a biological prosthesis A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and ... | 08/02/2011 |
| 7981596 | Tissue preservation with a salt solution isotonic with interstitial fluids The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. ... | 07/19/2011 |
| 7977041 | Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiolog... | 07/12/2011 |
| 7955788 | Bioprosthetic tissue preparation with synthetic hydrogels Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glut... | 06/07/2011 |
| 7955789 | Adhesion-preventing material and process for preventing adhesion An object of the present invention is to provide an adhesion-preventing material which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and produced with ease and has high practical uti... | 06/07/2011 |
| 7943292 | Physiologically acceptable aqueous solutions and methods for their use Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a h... | 05/17/2011 |
| 7927784 | Vascular lumen debulking catheters and methods A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly dispo... | 04/19/2011 |
| 7897326 | Peroxisome-proliferator activated receptor-alpha agonists for organ preservation Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARĪ±) agonist to the organ. ... | 03/01/2011 |
