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| Number | Title | Issue Date |
| 5591140 | Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood ... | 01/07/1997 |
| 5558900 | One-step thromboresistant, lubricious coating A method of making articles having lubricious polymeric coatings are disclosed. The coatings are comprised of a substantially homogeneous composite of poly(ethylene oxide) and polyisocyanate applied in a single step operation as a mixture in an inert solv... | 09/24/1996 |
| 5549924 | Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer Single and multiple layer membranes such as gloves and condoms include one or more deactivating barrier layers and/or indicating layers to indicate to a user membrane breach or the presence of a harmful substance in blood or body fluids. A membrane may in... | 08/27/1996 |
| 5547701 | Method of forming a paper applicator containing a water insoluble coating An applicator is disclosed for inserting a substance into a body cavity. The applicator is especially useful for inserting a catamenial tampon into a woman's vagina. The applicator includes a tubular member formed from at least one layer of paper which ha... | 08/20/1996 |
| 5543465 | Process for the production of hydrophilic membranes A process for the production of hydrophilic membranes using at least one hydrophobic polymer and polyvinyl pyrrolidone as a hydrophilic polymer, membrane-forming shaping of the polymers and immobilization of the polyvinyl pyrrolidone is characterized in t... | 08/06/1996 |
| 5537729 | Method of making ultra thin walled wire reinforced endotracheal tubing An ultra thin walled wire reinforced endotracheal tubing includes a thin walled tubing comprising a polymeric material having a spring material incorporated therewith. Utilization of the spring wire material in combination with polymeric material results ... | 07/23/1996 |
| 5514409 | Methods for coating invasive devices with inhibitors of thrombin This invention relates to coating invasive devies with novel biologically active molecules which bind to and inhibit thrombin. These molecules comprise a catalytic site directed moiety (CSDM) of the formula: ##STR1## wherein X is hydrogen or is chara... | 05/07/1996 |
| 5513654 | Slip-resistant contraceptive male condom The disclosed sheath-like contraceptive condom, even in a rolled-up condition suitable for packaging or use, has a high coefficient of friction on the surface that comes into contact with penile skin, particularly the portion of this surface contacting th... | 05/07/1996 |
| 5508060 | Method of polymer impregnation Methods of impregnating various polymer substrates with an impregnation additive, by simultaneously contacting the polymer substrate with an impregnation additive, carrier liquid, and supercritical fluid are provided. The impregnation additive is substant... | 04/16/1996 |
| 5498416 | Process for the protection of prostheses and of temporarily or permanently implantable material against bacterial colonization and infection A method for protecting prostheses and temporarily or permanently implantable materials from bacterial colonization and infection, wherein the material is successively impregnated with: (a) a biguanide solution having the general formula (I) ##STR1##... | 03/12/1996 |
| 5496581 | Polymeric coating A process for coating a surface comprising applying a solution containing a polymer obtained by polymerizing a phospholipid of the following formula (I): ##STR1##... | 03/05/1996 |
| 5486357 | Radiofrequency plasma biocompatibility treatment of inside surfaces Internal polymeric surfaces of medical devices are provided that have enhanced biocompatibility properties. The internal polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood flowing through... | 01/23/1996 |
| 5484565 | Method for making a medical catheter A polymeric article and method for making a polymeric article, such as a catheter, are disclosed wherein the article is contacted with a swelling agent, such as a solvent, and a plasticizer to make the polymeric material softer and/or more pliable or flex... | 01/16/1996 |
| 5482740 | Sustained release bactericidal cannula Methods of making sustained release bactericidal cannulas or catheters through which aqueous biological fluids can pass. The bactericidal cannula for catheter including a tube having an inner surface, defining and interior lumen, and an outer surface. The... | 01/09/1996 |
| 5474797 | Bactericidal coatings for implants Polymeric implants provided with coatings of bactericidal compounds in the form of ionized atoms by a vapor process. The polymeric implants include products designed to penetrate or enter the body, such as catheters, shunts connectors and the like. Coatin... | 12/12/1995 |
| 5464650 | Intravascular stent and method A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a... | 11/07/1995 |
| 5454881 | Method for marking thin walled tubes A method for marking thin walled tubes, using a laser. To prevent warping and to maintain the structural integrity of the tube, coolant is injected into the tube while it is being marked. To further prevent warping and to maintain the structural integrity... | 10/03/1995 |
| 5451424 | Anti-infective and antithrombogenic medical articles and method for their preparation An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithr... | 09/19/1995 |
| 5441759 | Method to stabilize TDMAC heparin coating A medical device is coated with a solution of TDMAC heparin and then allowed to air dry. Thereafter, the coated medical device is exposed to gamma ray radiation. The gamma radiation strengthens the bond of the TDMAC to the material of the medical device. ... | 08/15/1995 |
| 5416131 | Article with a coating having friction-reducing properties in wet condition as well as a method for the production of such a coated article A method of producing an article with a coating having friction-reducing properties in wet condition, the coating including a binder (a), a hydrophilic polymer (b), as well as an osmolality-increasing compound (c), where the osmolality-increasing compound... | 05/16/1995 |
| 5409696 | Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood ... | 04/25/1995 |
| 5380904 | Process for rendering a surface biocompatible, and articles containing the same A compound of formula: ##STR1## in which X1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X2 is a group --O.crclbar. or a ... | 01/10/1995 |
| 5376400 | Combined plasma and gamma radiation polymerization method for modifying surfaces A method for modifying the surface of a material by: a. exposing the surface to a glow discharge plasma to activate the surface; b. exposing the surface to an ethylenically unsaturated monomer or mixture of monomers; and c. irradiating the activated surface with ga... | 12/27/1994 |
| 5370900 | Thin-fingered medical glove A process for making medical gloves whose fingers have thinner walls than the rest of the gloves involves first depositing onto a hand-shaped glove form a layer of coagulant that comprises an ionic metal salt, then depositing an elastomeric layer. Part of... | 12/06/1994 |
| 5370899 | Catheter having lubricated outer sleeve and method for making same An elongated catheter having an interior and an exterior surface, wherein the interior surface defines a lumen passing through the catheter. The catheter further including an enclosed cavity between the interior and exterior surfaces which encircles of th... | 12/06/1994 |
| 5340614 | Methods of polymer impregnation Methods of impregnating various polymer substrates with an impregnation additive, by simultaneously contacting the polymer substrate with an impregnation additive, carrier liquid, and supercritical fluid are provided. The impregnation additive is substant... | 08/23/1994 |
| 5338312 | Article having multi-layered lubricant and method therefor An article having surfaces in sliding contact is lubricated at the interface with a multi component system. A first crosslinked basement lubricant is coated onto a surface, such as a syringe barrel. A second lubricant is coated over the crosslinked lubric... | 08/16/1994 |
| 5338565 | Method of forming a membrane, especially a latex membrane, having a biocide barrier Methods of forming a chemical barrier against the transmission of disease-causing microbes and other harmful agents through a membrane such as latex. In the principal method, a mold or former is coded with a coagulant, which is dried, and then the former ... | 08/16/1994 |
| 5308641 | Biocompatibility of solid surfaces An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in a... | 05/03/1994 |
| 5295978 | Biocompatible hydrophilic complexes and process for preparation and use Biocompatible polymeric complexes having utility in many fields including medical applications, as well as personal and health care, are provided and can be affixed to a variety of substrate materials which themselves may or may not also be biocompatible.... | 03/22/1994 |
| 5290585 | Lubricious hydrogel coatings A flexible, lubricious organic coating is formed by applying a mixture of an isocyanate, a polyol, polyvinylpyrrolidone (PVP), and carrier liquid to a surface to be coated. The carrier liquid is removed and the mixture reacted to form a lubricious, flexib... | 03/01/1994 |
| 5275838 | Immobilized polyethylene oxide star molecules for bioapplications A method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogel layers and a product thereof are disclosed. The PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecule laye... | 01/04/1994 |
| 5272012 | Medical apparatus having protective, lubricious coating A method for providing a medical apparatus with a protective, lubricious coating is described. The method comprises providing a coating solution which contains a protective compound such as a urethane, a slip additive such as a siloxane, and optionally, a... | 12/21/1993 |
| 5258041 | Method of biomolecule attachment to hydrophobic surfaces A method for attaching a biomolecule to a support having a hydrophobic surface, involving the use of a long chain chemical spacer having a hydrophobic guiding group capable of becoming embedded in the surface, and the biomolecule being covalently bound to... | 11/02/1993 |
| 5244654 | Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like Internal polymeric surfaces of medical devices are provided that have enhanced biocompatibility properties. The internal polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood flowing through... | 09/14/1993 |
| 5217743 | Biomaterials of enhanced biocompatibility The present invention provides a process for enhancing biomaterial biocompatibility. A biocompatibility-enhancing coating is covalently attached to a biomaterial surface through spacer arm-providing molecules previously covalently bonded to the functional... | 06/08/1993 |
| 5217492 | Biomolecule attachment to hydrophobic surfaces A long chain chemical spacer useful for attaching a biomolecule to a support having a hydrophobic surface, the spacer having a hydrophobic guiding group capable of becoming embedded in the surface, and optionally including a stopping group and/or an attac... | 06/08/1993 |
| 5212000 | Method for providing an inner-skinned functionalized coating on the lumen-defining surface of a hollow tube This invention provides a method for providing a functionalized inner skin on the lumen-defining surface of a hollow tube using either a Newtonian coating fluid used in combination with a relatively non-Newtonian plug fluid, or a non-Newtonian coating flu... | 05/18/1993 |
| 5186972 | Method for lubricating articles In a method for lubricating articles, a liquid composition including a gelling agent dissolved in a lubricant is applied to the surface of an article and caused to gel on the article. Gelling may be induced by applying the liquid composition to an article... | 02/16/1993 |
| 5180605 | Gloves, their manufacture and use Antimicrobial gloves such as those made of natural rubber latex may be manufactured by incorporating an antimicrobially effective amount of a non-ionic, sparingly water soluble antimicrobial agent, such as 2,4,4'-tricloro-2'-hydroxyphenyl ether, into the ... | 01/19/1993 |
