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| Number | Title | Issue Date |
| 8163277 | Kits for treating dysfunction of cardiac muscle Kits are described for the treatment of acute or chronic dysfunction of cardiac muscle. The kit includes a platelet-rich plasma composition with a pH adjusting agent and a catheter or syringe for delivery of the platelet-rich plasma composition to dysfunctional card... | 04/24/2012 |
| 8088371 | Compositions and minimally invasive methods for treating peripheral vascular disease Methods are described for using compositions containing platelet-rich plasma for the treatment of peripheral vascular disease. A platelet-rich plasma composition is introduced into the muscle or soft tissue in the area of hypovascularity to treat the peripheral vasc... | 01/03/2012 |
| 8052969 | Method of making plasma enriched with platelets using a double syringe system where the second sytringe is within the first syringe and use thereof A method of providing autologous conditioned plasma (ACP) for treatment of connective tissue injuries. The method comprises the steps of: (i) providing an apparatus comprising a centrifuge and a double syringe, the double syringe including an inner syringe body and ... | 11/08/2011 |
| 7939063 | Delivery vehicle for recombinant proteins Recombinant nucleic acid molecules are constructed with a first sequence encoding a transgene under the control of regulatory sequences that direct expression of the transgene product in a hematopoietic stem cell, or a progenitor cell therefrom or cell differentiate... | 05/10/2011 |
| 7901674 | Aldehyde-fixed platelets with internalized paramagnetic or magnetic nanoparticles Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the sane. The blood cells may be red blood cells or blood platelets. ... | 03/08/2011 |
| 7892535 | Preventing transfusion related complications in a recipient of a blood transfusion This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with li... | 02/22/2011 |
| 7811558 | Use of stabilized platelets as hemostatic agent The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a hemostat, such as for treating bleeding or injuries associated with bleeding. It also provides methods of treating injuries or wounds, and methods of ... | 10/12/2010 |
| 7718167 | Method for treating wounds exposing the dura using PPP and PRP A method for treating an open wound, such as a surgical wound, may include preparing a first composition including a platelet poor plasma (PPP), and preparing a second composition including a platelet rich plasma (PRP). A layer of the first composition may be applie... | 05/18/2010 |
| 7608258 | Method for treatment of tendinosis using platelet rich plasma Methods and kits are disclosed to promote vascularization of tissue in mammals using an autologous platelet-rich plasma composition. The kit includes components for the preparation of platelet-rich plasma from the patient's blood and components for administration to... | 10/27/2009 |
| 7413865 | Diagnostic method for a transmissible spongiform encephalopathy or prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or plat... | 08/19/2008 |
| 7314617 | PRP composition and minimally invasive method for treating myocardial infarction Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions. Particularly, delivery of platelet-rich plasma to connective tissue is described. The described method and compositions have been shown to ... | 01/01/2008 |
| 7294455 | Fixed-dried platelets cross-linked to protein Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells may be red blood cells or blood platelets. ... | 11/13/2007 |
| 7291450 | Preparation of a cell concentrate from a physiological solution The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specifi... | 11/06/2007 |
| 7285266 | Cell-polymer fiber compositions and uses thereof The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising p... | 10/23/2007 |
| 7253142 | Protein solution preparation and method of stabilizing the same The present invention provides stable protein solution formulations filled in a container made from a hydrophobic resin at least for the part in direct contact with said formulation. ... | 08/07/2007 |
| 7244552 | Artificial dermis and production method therefor Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fi... | 07/17/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7169606 | Lyophilization of human platelets A protectant mixture for use in preserving biological materials comprising at least one polyhydroxy compound, and phosphate ions; a preservation medium comprising a biological material, at least one polyhydroxy compound, and phosphate ions; methods of preserving the... | 01/30/2007 |
| 7122182 | Oncolytic virus therapy A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acce... | 10/17/2006 |
| 7112342 | Enriched platelet wound healant An improved platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises a therapeutically effective amount of activated growth factors and ascorbic acid with optional one or more addit... | 09/26/2006 |
| 7022347 | Restorative and grafting material for hard tissue defects prepared from animal teeth The restorative and grafting material for reconstruction of hard tissue defects and the fabrication method of the same are provided. In particular, the restorative and grafting material of this invention is produced by the steps of cleansing, decoloration (bleaching... | 04/04/2006 |
| 7015198 | Materials for soft tissue augmentation and methods of making and using same Materials for soft tissue augmentation in mammals are prepared by cross-linking blood plasma proteins, preferably with a zero-length cross-linking agent. The cross-linked blood plasma proteins can be dialyzed and autoclaved. Such materials are non-antigenic, exhibit... | 03/21/2006 |
| 6962787 | Diagnostic method for a transmissible spongiform encephalopathy or a prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or plat... | 11/08/2005 |
| 6955682 | Wound closure system and methods A wound closure system and methods utilizes a patient's own blood. The system preferably includes a chamber with a needle and a plunger for transferring and storing blood prior to surgery and the use of reversible anticoagulants. The chamber is pre-loaded with a rev... | 10/18/2005 |
| 6811777 | Compositions and minimally invasive methods for treating incomplete connective tissue repair Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions. Particularly, delivery of platelet-rich plasma to connective tissue is described. The described method and compositions have been shown to ... | 11/02/2004 |
| 6610291 | Ready-to-use ristocetin cofactor test reagent possessing long-term stability The present invention relates to a ready-to-use ristocetin cofactor test reagent possessing long-term stability for use in coagulation tests.... | 08/26/2003 |
| 6524568 | Enriched platelet wound healant An improved platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises a therapeutically effective amount of activated growth factors and ascorbic acid with optional one or... | 02/25/2003 |
| 6413714 | Process for the sterilization of biological compositions and the product produced thereby The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucida... | 07/02/2002 |
| 6372423 | Method for stabilizing platelets The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an... | 04/16/2002 |
| 6322785 | Methods and compositions for bone graft implants An autologous platelet gel for bone grafts is comprised of a mixture of platelet-rich-plasma activated by calcium chloride solution, and an aqueous suspension of partially frayed Type I collagen.... | 11/27/2001 |
| 6303112 | Enriched platelet wound healant A wound healant composition comprising a therapeutically effective amount of activated growth factors and ascorbic acid and/or at least one retinoid and/or at least one antibiotic, that facilitates the growth of new tissue.... | 10/16/2001 |
| 6218100 | 5'-primary aminoalkyl psoralen compositions with platelets Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa... | 04/17/2001 |
| 6214338 | Plasma concentrate and method of processing blood for same A plasma concentrate comprising one of platelets and platelet releasate and from 5 to 400 mg/ml of fibrinogen. The concentrate further includes a physiologically acceptable carrier comprising water and physiologically acceptable inorganic and organic ions... | 04/10/2001 |
| 6159443 | X-ray guided drug delivery A method of delivering an active agent to a target tissue, particularly neoplastic tissue, vascular anomaly or tumor tissue, in a vertebrate subject. The method includes the steps of exposing the target tissue to ionizing radiation; and administering a de... | 12/12/2000 |
| 6127111 | Lyophilized platelet composition containing chloroquine, hydroxychloroquine, camoquin, quinacrine or procaine The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an... | 10/03/2000 |
| 6087141 | Process for the sterilization of biological compositions and the product produced thereby The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucida... | 07/11/2000 |
| 6017691 | 4'-primary aminopsoralen and platelet compositions Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa... | 01/25/2000 |
| 6004742 | Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic add of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in saf... | 12/21/1999 |
| 6004741 | Method for the photoactivation of 4' and 5' primary aminoalkyl psoralens in platelet preparations Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa... | 12/21/1999 |
| 5993804 | Pharmaceutically acceptable fixed-dried human blood platelets Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thro... | 11/30/1999 |
