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| Number | Title | Issue Date |
| 7238528 | Means and methods for fibroblast-like or macrophage-like cell transduction The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect, the nucleic acid delivery vehicle is a virus capsid or a function... | 07/03/2007 |
| 7238674 | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection,... | 07/03/2007 |
| 7238345 | Recombinant microorganism expressing meningococcal class 1 outer membrane protein Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal disease. ... | 07/03/2007 |
| 7238777 | Agents for adsorption and bridging for adenovirus The object of the present invention is to provide an agent for specific adsorption of type 5 adenoviral vector to undifferentiated blood cells which enables infection with a viral concentration that does not impart toxicity to undifferentiated blood cells, without r... | 07/03/2007 |
| 7235395 | Lactic acid bacteria as agents for treating and preventing allergy The present invention pertains to novel strains of lactic acid bacteria capable of reducing an individual's tendency to react allergic against a variety of different allergens. In particular, the present invention relates to recombinant strains of lactic acid bacter... | 06/26/2007 |
| 7235235 | Alphavirus RNA replicon systems The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) ... | 06/26/2007 |
| 7235236 | Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure. ... | 06/26/2007 |
| 7235391 | Formulation of adenovirus for gene therapy The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired ... | 06/26/2007 |
| 7235654 | Methods for modulating IKKα activity A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription. ... | 06/26/2007 |
| 7235234 | Bacterial delivery system We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA and antigens into the cell cytoplasm. This Shigella ... | 06/26/2007 |
| 7233340 | Linking of images to enable simultaneous viewing of multiple objects Computerized techniques are provided for linking digitized images of serial sections of a biological tissue sample. Linked, digitized images of the serial section are displayed on a display and manipulation of one digitized image causes other digitized images to be ... | 06/19/2007 |
| 7232899 | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the developm... | 06/19/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7230167 | Modified Cry3A toxins and nucleic acid sequences coding therefor Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site such as cathepsin G, that... | 06/12/2007 |
| 7226589 | Treatment of diseases by site specific instillation of cells or site specific transformation of cells and kits therefor A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothel... | 06/05/2007 |
| 7226587 | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses composition... | 06/05/2007 |
| 7226588 | Non-toxic mutants of pathogenic gram-negative bacteria A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a m... | 06/05/2007 |
| 7226779 | Hybrid adenoviral vector An adenoviral vector is disclosed that includes two adenoviral ITRs, wherein the two adenoviral ITRs flank a packaging signal and a single retroviral LTR operably linked to a nucleic acid sequence of interest, wherein the adenoviral vector does not include a nucleic... | 06/05/2007 |
| 7223593 | Herpes virus strains for gene therapy The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene. ... | 05/29/2007 |
| 7225028 | Dual cochlear/vestibular stimulator with control signals derived from motion and speech signals A system for treating patients affected both by hearing loss and by balance disorders related to vestibular hypofunction and/or malfunction, which includes sensors of sound and head movement, processing circuitry, a power source, and an implantable electrical stimul... | 05/29/2007 |
| 7223390 | Insertion of furin protease cleavage sites in membrane proteins and uses thereof Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be u... | 05/29/2007 |
| 7223389 | Compositions and methods for treatment of cancer The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment o... | 05/29/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7223585 | Viral purification methods The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filt... | 05/29/2007 |
| 7220582 | Stem cells that transform to beating cardiomyocytes Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein to differentiate the spoc cells, and to utilize these spoc cells for... | 05/22/2007 |
| 7220418 | Delivery of trefoil peptides The present invention relates to a microorganism, preferably a bacterial strain, preferably a non-pathogenic strain, preferably a non-invasive strain, preferably a food grade strain, preferably a gram-positive bacterial strain, delivering a trefoil peptide in vivo. ... | 05/22/2007 |
| 7221988 | Creation and display of indices within a process plant A process control system uses an asset utilization expert to collect data or information pertaining to the assets of a process plant from various sources or functional areas of the plant including, for example, the process control functional areas, the maintenance f... | 05/22/2007 |
| 7217699 | Compositions comprising genome segments and methods of using the same Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, or preventing an individual from developing a disease or disorder associated with one or more genet... | 05/15/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7217541 | Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic infections Disclosed herein are methods for making large amounts of highly pure colonization factors. The methods of the present invention differ from prior art methods in that host cells which express the colonization factor of interest are cultured in media comprising more t... | 05/15/2007 |
| 7214368 | Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encodin... | 05/08/2007 |
| 7214369 | Devices and processes for distribution of genetic material to mammalian limb A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution i... | 05/08/2007 |
| 7214858 | Plant genes encoding trehalose metabolism enzymes This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction... | 05/08/2007 |
| 7211247 | Lentivirus vectors for gene transfer to alveolar epithelial cells The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI an... | 05/01/2007 |
| 7211411 | Human papilloma virus treatment Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disc... | 05/01/2007 |
| 7211248 | Enhancement of transfection of DNA into the liver A method for transfection of DNA or RNA encoding apo A1 into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver in combination with gas microbubbles or microspheres and using ultrasound to induce th... | 05/01/2007 |
| 7208161 | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to pr... | 04/24/2007 |
| 7208164 | Ovo immunization against infectious bronchitis The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live, avirulent strains of IB at appropriate dosage levels on a per egg basis... | 04/24/2007 |
| 7208313 | Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype. ... | 04/24/2007 |
| 7205013 | Recombinant RSV virus expression systems and vaccines The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant ... | 04/17/2007 |
