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| Number | Title | Issue Date |
| 8092783 | Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+ | 01/10/2012 |
| 8092782 | Polybiotin compounds of magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 01/10/2012 |
| 8021646 | Compositions and methods for magnetic resonance imaging contrast agents The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that comprise monodisperse, protein polymer backbones capable of chelating multip... | 09/20/2011 |
| 8012458 | Rare-earth amidate coordination compounds The invention is directed to a lanthamide chelate composition having a lanthamide, a charged amidate ligand, and a mono- or bidentate neutrally charged coordination compound, the composition being represented by structure I or structure II | 09/06/2011 |
| 7504088 | Lipophilic derivatives of chelate monoamides Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. The compounds are conveniently prepared from achir... | 03/17/2009 |
| 7438893 | Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 10/21/2008 |
| 7419654 | Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the para... | 09/02/2008 |
| 7371225 | Method for convection enhanced delivery of therapeutic agents A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the... | 05/13/2008 |
| 7368099 | MRI contrast agents An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signal... | 05/06/2008 |
| 7367155 | Apparatus and methods for analyzing and improving agricultural products A trait of interest is detected as being present within individual ones of a plurality of agricultural samples (such as seeds or plant tissues) by imaging the plurality of samples to form a magnetic resonance image. The image of the plurality of samples is then anal... | 05/06/2008 |
| 7366561 | Robotic trajectory guide A surgical alignment device is shown that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neur... | 04/29/2008 |
| 7354568 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 04/08/2008 |
| 7344704 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as... | 03/18/2008 |
| 7341711 | Porphyrin compounds and their use in high-field MRI A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided: in which R0 and R′0 are such that the compoun... | 03/11/2008 |
| 7338651 | Multi-use multimodal imaging chelates Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester ... | 03/04/2008 |
| 7312251 | Synthesis of stable solutions of rare earth tris (organophosphate) in hydrocarbon solvents Stable rare earth tris (organophosphate) solutions comprise a rare earth tris (organophosphate) and a hydrocarbon solvent. From about 2% to about 10% rare earth element, preferably from about 3% to about 8%, is present in the solutions. The rare earth tris (organoph... | 12/25/2007 |
| 7303741 | Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, a... | 12/04/2007 |
| 7279150 | Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ... | 10/09/2007 |
| 7251520 | Method and apparatus of slice selective magnetization preparation for moving table MRI The present invention is directed to slice selective magnetization preparation for moving table MRI. The present invention includes a method of magnetization preparation that takes into account patient movement or translation during the imaging process. The present ... | 07/31/2007 |
| 7249604 | Medical devices for occlusion of blood flow The present invention discloses a method for the occlusion of blood vessels or fluid vessels to stop the flow of blood or fluid during elective or emergency surgical procedures or following traumatic injury. This invention also encompasses a medical device or tool f... | 07/31/2007 |
| 7244413 | Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of produci... | 07/17/2007 |
| 7238341 | Peptide-based multimeric targeted contrast agents Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents. ... | 07/03/2007 |
| 7229606 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/12/2007 |
| 7226578 | Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear ... | 06/05/2007 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7208140 | Trimeric macrocyclic substituted benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine and A1 and A2 have different meanings, are suitable as contrast media. ... | 04/24/2007 |
| 7208139 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable comp... | 04/24/2007 |
| 7208134 | Bioprocesses enhanced by magnetic nanoparticles One aspect of the present invention relates to magnetic nanoparticles colloidally stabilized in aqueous milieu by association with an organic phase. The organic phase may be either a fluorinated polymer or an organic hydrocarbon bilayer, wherein the two layers are c... | 04/24/2007 |
| 7198776 | Metal complex compounds The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said me... | 04/03/2007 |
| 7186400 | Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy Compounds of general formula (I): in which: R1 is hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyc... | 03/06/2007 |
| 7179450 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 02/20/2007 |
| 7175829 | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SD... | 02/13/2007 |
| 7174200 | Optimized high-speed magnetic resonance imaging method and system using hyperpolarized noble gases A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic magnetic resonance images. The strong magnetic resonance signal from hyperpo... | 02/06/2007 |
| 7138105 | Compositions for delivery of therapeutics and other materials, and methods of making and using the same In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent. ... | 11/21/2006 |
| 7132513 | Bifunctional chelating agent The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO2, —NH2, —NCS, —NHCOCH2-Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or —NHCO(CH2)m... | 11/07/2006 |
| 7128895 | Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed. ... | 10/31/2006 |
| 7110806 | Method for imaging an artery using a magnetic resonance contrast agent The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of ... | 09/19/2006 |
| 7090636 | Permanent magnet keeper-shield assembly A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field that, in one embodiment, may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet ... | 08/15/2006 |
| 7078013 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are... | 07/18/2006 |
| 7074387 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as NMR shift reagents. | 07/11/2006 |
