Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7883688 | Polycationic polyrotaxanes capable of forming complexes with nucleic acids A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the termin... | 02/08/2011 |
| 7767196 | Optimized relaxivity and specificity hepatobiliary MRI contrast agent An adamantane functionalized magnetic resonance imaging (MRI) contrast agent has been synthesized, and shows high liver specificity, prolonged retention time in both the liver and kidneys, the highest relaxivity among clinical contrast agents, high water solubility,... | 08/03/2010 |
| 7354568 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 04/08/2008 |
| 7326404 | Konjac-mannan and ginseng compositions and methods and uses thereof The present invention relates to a number of compositions namely a konjac-mannan mixture, a ginseng composition and a composition comprising konjac-mannan and American ginseng. Methods of use are described including their use for reducing blood glucose... | 02/05/2008 |
| 7235227 | Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as... | 06/26/2007 |
| 7198776 | Metal complex compounds The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said me... | 04/03/2007 |
| 7005517 | Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance Imaging), diagnostic X-ray imaging and computed tomography(CT). Th... | 02/28/2006 |
| 6790942 | Biologically active conjugates having a detectable reporter moiety and method of identification of the derivative Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH2—CH2O)n—(CO)—NH—X—(CO)—NH—Z wherein R represents a lower ... | 09/14/2004 |
| 6713045 | Targeted magnetic resonance imaging agents for the detection of physiological processes The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 03/30/2004 |
| 6673333 | Functional MRI agents for cancer imaging The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.... | 01/06/2004 |
| 6649591 | Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in accordance with the present invention, dithiocarbamates are l... | 11/18/2003 |
| 6630121 | Supercritical fluid-assisted nebulization and bubble drying A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and pas... | 10/07/2003 |
| 6599498 | Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall s... | 07/29/2003 |
| 6559330 | CALCIUM COMPLEX OF [[(4R)-4-[BIS{CARBOXY-.KAPPA.O)METHYL]AMINO-.KAPPA.N]-6,9-BIS[(CARBOXY. KAPPA. O)METHYL]-1-[(4,4-DIPHENYLCYCLOHEXYL)OXY]-1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOS PHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011]1-OXIDATO(6-)]-, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS The invention relates to the calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.k appa. O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phos phaundecan-11-ylic-acid-.kappa.N6,.kappa. N9,.ka... | 05/06/2003 |
| 6482429 | Stable powder inhalation dosage formulation An insufflation for the administration of a drug into a body cavity is described where the carrier for the drug is a finely divided powder selected from the group consisting of myoinositol, mannitol and cellobiose.... | 11/19/2002 |
| 6451980 | Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient... | 09/17/2002 |
| 6429297 | Modified avidin and streptavidin and methods of use thereof The present invention relates to a compound of the formula ##STR1## These modified streptavidin compounds have are useful as part of a delivery system to deliver a molecule to a target site for use in diagnosis or therapy.... | 08/06/2002 |
| 6423314 | Tumor derived carbohydrate binding protein The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an immunotherapeutic agent. Identification of the site makes possible an in ... | 07/23/2002 |
| 6409990 | Macromolecular carrier for drug and diagnostic agent delivery New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes and their facile creation, reaction and conjugation with ch... | 06/25/2002 |
| 6369043 | Sodium ion absorption inhibitors, sodium ion excretion accelerators, and preventive and therapeutic agents for diseases resulting from excessive intake of common salt An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal salt (excluding sodium salt) of lambda-carrageenan as an ... | 04/09/2002 |
| 6329208 | Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13 C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3-13 C3 ]propionate are presented. This i... | 12/11/2001 |
| 6312664 | Biodegradable contrast media for MR imaging A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnet... | 11/06/2001 |
| 6287538 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 a... | 09/11/2001 |
| 6268351 | Methods for inducing proliferation in auditory receptor epithelium The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable regeneration of hair cells in the cochlea. These agents may be admini... | 07/31/2001 |
| 6214621 | Conjugates of a particle vector and oligonucleotides, process for their preparation, and pharmaceutical compositions containing them The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of polyanionic oligonucleotides. The invention further concerns... | 04/10/2001 |
| 6113880 | Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.... | 09/05/2000 |
| 6107459 | Technetium-99m labeled peptides for diagnostic imaging This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled peptides that specifically bind to sites of infection, infl... | 08/22/2000 |
| 6068831 | Pseudopolyrotaxanes The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane complexes have general formula (I), in which n represents th... | 05/30/2000 |
| 6033644 | Biomodulators as universal imaging agents Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to... | 03/07/2000 |
| 6022865 | Stable aqueous solution having high concentrations of calcium and phosphate ions and solid complex A stable aqueous solution having high concentrations of both biologically available calcium and biologically available phosphate is provided by combining phosphate and calcium ions in the aqueous solution wherein the phosphate is in the form of a sacchari... | 02/08/2000 |
| 6017901 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions Hyaluronic acid or hyaluronic acid ester derivatives, wherein one or more hydroxy functions of its 1,4ଲ-D-glucuronic acid and 1,3-ଲ-N-acetyl-D-glucosamine alternating repeating units are esterified with a carboxyl group of succinic acid to for... | 01/25/2000 |
| 6010681 | Biodegradable blood-pool contrast agents The invention provides a blood pool contrast agent having an overall molecular weight of at least 10KD comprising a macrostructure which has bound thereto a plurality of opsonization inhibiting moieties and carries chelated ionic paramagnetic or heavy met... | 01/04/2000 |
| 5985244 | Polymers with a gas magnetic resonance imaging Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density c... | 11/16/1999 |
| 5985245 | Contrast agents for MRI using a manganese compound and kojic acid There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an -hydroxy ketone group, or salt thereof, ha... | 11/16/1999 |
| 5980862 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.... | 11/09/1999 |
| 5968477 | Radiolabeled annexin conjugates with hexose and a chelator Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.... | 10/19/1999 |
| 5965131 | Delivery of diagnostic and therapeutic agents to a target site An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i... | 10/12/1999 |
| 5958408 | Delivery of diagnostic and therapeutic agents to a target site An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i... | 09/28/1999 |
| 5928626 | Contrast agents, consisting of carbohydrate particles The present invention relates to contrast agents comprising water-soluble microbubble-generating carbohydrate microparticles in admixture with at least 10% w/w relative to the overall composition of a non-surface active material which is less water solubl... | 07/27/1999 |
| 5928958 | Superparamagnetic particles, process for their manufacture and usage Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound organic substances optionally having further binding sites for coupling to tissue-specific b... | 07/27/1999 |
