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Patent No. 5678617

Method and apparatus for making a drink hop along a bar or counter

A method for generating a drink which appears to hop from a remote spot on the bar or counter and take one or more leaps, before landing in a patron's glass.

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Class 424/9.341 - The region of the imaging agent responsible for binding to an in vivo target or the region of the target responsible for binding to the agent is specifically recited functionally or as a sequence of amino acids, carbohydrate residues, or nucleic acids


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the polypeptide attached to said
No. of patents: 70
Last issue date: 05/13/2008


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NumberTitleIssue Date
7371365Methods for detecting parenchymal plaques in vivo
Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amy...
05/13/2008
7344699Drug conjugate comprising an erythropoietin receptor ligand and an anticancer agent
A drug conjugate comprising a targeting agent and an anti-cancer agent, wherein said targeting agent comprises an erythropoietin receptor ligand, is described. The drug conjugate can be used in methods of treating cancer. Also described are methods of treating cance...
03/18/2008
7220402Alpha-fetoprotein peptides and uses for imaging
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to t...
05/22/2007
7087722Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of b...
08/08/2006
7041506Peptides promoting cell adherence, growth and secretion
The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in large quantity by such means as chemical synthesis or recombinant DNA ...
05/09/2006
7022309Targeting molecule linked to an imaging agent
Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having β-sheet character, each of the domains being...
04/04/2006
6984374Method for the evaluation of implantable materials
A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the ...
01/10/2006
6869592Method and antibody for imaging lung cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer. ...
03/22/2005
6855551Biological applications of quantum dots
The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by controllin...
02/15/2005
6743781Glycerolipid compounds useful for the transfer of an active substance into a target cell
The invention concerns novel compounds of formula (I) in which: R1 and R2, which are identical or different, are C6-C23 alkyl or alkenyl radicals, linear or branched or —C(â•...
06/01/2004
6737040Method and antibody for imaging breast cancer
The present invention provides a new method of detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating breast cancer. ...
05/18/2004
6719973Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for anti-microbial, anti-endotoxin, and anti-sepsis therapy. SSCrFCES is...
04/13/2004
6713046Magnetic resonance imaging agents for the delivery of therapeutic agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents. ...
03/30/2004
6699723Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting el...
03/02/2004
6610651Molecules that home to various selected organs or tissues
The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor ...
08/26/2003
6602852Basic peptides and pharmaceutical compositions containing same
The present invention relates to an NST300 compound of general formula (I): comprising the following components: X1--[(X3)a/(X4)b] in which X1 represents a fatty acid or prenyl group; and X3 represents a domain of positively charged amino acids; and X4 re...
08/05/2003
6599499Uses of diterpenoid triepoxides as an anti-proliferative agent
Combinations of diterpenoid triepoxides and anti-proliferative agents are used in a combination therapy to treat hyperproliferative disorders. Anti-proliferative agents of interest include agents active in killing tumor cells, as well as immunosuppressant...
07/29/2003
6503540Cloning and characterization of bves, a novel gene expressed in heart and uses thereof
The present invention is directed to cloning and characterization of bves (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick, mouse and human. Also provided are applications of Bves as a ...
01/07/2003
6455025Polysaccharide-peptide derivatives
Polysaccharide-somatostatin analogs of the formula: ##STR1## wherein the somatostatin analog is directly or indirectly coupled from a terminal N-amino group of the somatostatin analog to a polysaccharide, and the polysaccharide-somatostatin analog is prov...
09/24/2002
6451980Signal enhancement of bispecific antibody-polymer probe for immunoassay use
An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient...
09/17/2002
6423551Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting el...
07/23/2002
6391280J chain polypeptide targeting molecule linked to an imaging agent
Polypeptide targeting molecules are provided for use in delivering imaging agents to epithelial tissue. Upon delivery, the imaging agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molec...
05/21/2002
6375928Neutrophil stimulating peptides
The present invention provides peptides capable of stimulating neutrophils. In particular, the peptides prime neutrophils for a respiratory burst following treatment with N-formyl-L-methionyl-L-leucyl-L-phenylalanine. The peptides have an amino acid seque...
04/23/2002
6323186Phosphate-bound polyazaindacene derivatives of nucleotides
The invention relates to dipyrrometheneboron difluoride-substituted nucleotides substituted by a dipyrrometheneboron difluoride label on a phosphate moiety. The nucleotides of the invention are useful in fluorescence assays, including protein binding assa...
11/27/2001
6312661Method for the detection and localization of ductal exocrine pancreas tumours
The invention relates to a method of detecting and localizing malignant tumors and their metastases in tissues, which in healthy condition and in non-neoplastic conditions of chronic inflammation do not contain substantial quantities of neurotensin-recept...
11/06/2001
6274121Superparamagnetic particles, process for their manufacture and use
Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound inorganic and optionally organic substances optionally having further binding sites for coup...
08/14/2001
6261535Diagnostic methods for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are target...
07/17/2001
6232287Molecules that home to various selected organs or tissues
The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor ...
05/15/2001
6107102Therapeutic microdevices and methods of making and using same
A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am range. Also disclosed are microfabrication methods for making s...
08/22/2000
6045774J chain polypeptide targeting molecule linked to an imaging agent
Targeting molecules for use in delivering imaging agents to epithelial tissue are disclosed. Upon delivery, the imaging agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be...
04/04/2000
5965131Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i...
10/12/1999
5958408Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i...
09/28/1999
5869616Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being c...
02/09/1999
5846725Methods for identifying cisplatin resistant tumor cells
Isolated nucleic acids which can confer on a cell at least a 5-fold increase in cisplatin resistance relative to a cisplatin sensitive cell are disclosed. The nucleic acids of the invention can further confer on a cell resistance to heavy metals such as c...
12/08/1998
5792444Labeled chemotactic peptides to image focal sites of infection or inflammation
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detec...
08/11/1998
5770569Diagnostic and therapeutic agents using a lymphocyte adhesion receptor for high endothelium CD44
A lymphoid cell line cDNA that encodes an adhesion receptor for high endothelial venules (HEV)....
06/23/1998
5759519Method for the intracellular delivery of biomolecules using thiocationic lipids
Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging agents, proteins and drug molecules. In the form of liposomes,...
06/02/1998
5738838IKVAV peptide radiopharmaceutical applications
Peptides useful for lung imaging, and preferably containing a biological-function domain which includes the sequence Ile-Lys-Val-Ala-Val (IKVAV) (SEQ. ID NO. 1) and a medically useful metal ion-binding domain are labeled with medically useful metal ions f...
04/14/1998
5698178Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
Polyspecific immunoconjugates and antibody composites that bind a multidrug transporter protein and an antigen associated with a tumor or infectious agent are used to overcome the multidrug resistant phenotype. These immunoconjugates and composites also c...
12/16/1997
5670479଱-ketoamide derivatives as inhibitors of thrombosis
a-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions, diagnostic compositions and pharmaceutical compositions, which are useful for preventing or treating in a mammal a pathological condition characterized by thrombosis are descr...
09/23/1997
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