Class 424/9.33 - Nitroxide or nitroxide containing

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the agent is a nitroxide or contains
No. of patents: 40
Last issue date: 04/01/2008

Number	Title	Issue Date
7351402	Polarizing agents for dynamic nuclear polarization We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two paramagnetic centers. In a preferred embodiment, the polarizing agent compri...	04/01/2008
7126332	Downhole high resolution NMR spectroscopy with polarization enhancement An apparatus and method is discussed for characterizing a fluid sample downhole of aliphatic hydrocarbon compounds, aromatic hydrocarbon compound, or connate mud filtrates containing carbon-13 isotopes using an enhanced nuclear magnetic resonance (NMR) signal on a m...	10/24/2006
7108846	Methods for preparing perfluorinated [f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as indicators for tissue hypoxia. More particularly, the present invention...	09/19/2006
7105546	Acyclic and cyclic amine derivatives The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizin...	09/12/2006
7097825	Methods and reagents to acquire MRI signals and images Method for obtaining BOLD MRI images with allosteric effector compounds are disclosed. Methods for the determination of tumor oxygenation and for an optimal time for initiating radiation therapy are also disclosed. ...	08/29/2006
7022729	Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of tr...	04/04/2006
6991778	Use of dendrimers polyl-functionalized with nitroxide groups as contrast enhancing agents in MRI imaging of joints and injectable compositions comprising them The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e...	01/31/2006
6952098	Method of evaluating green malt qualities by electron spin resonance spectrometry and method of evaluating malt qualities A method is provided in which a correlation is made between a parameter indicating modification of a sampled malt in a germination process in which barley is germinated, and an ESR signal intensity of the sampled malt. The parameter is determined, in advance, by gen...	10/04/2005
6632975	Method for the production of in vivo model of hepatocellular carcinoma without lung metastasis The present invention provides a method for producing an in vivo model of hepatocellular carcinoma without lung metastasis in an animal by injecting diethylnitrosamine and administering nitrosomorpholine in the drinking water of the animal, as well as, me...	10/14/2003
6569688	Intravascular apparatus method Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier (2) for insertion into the vessel; and a biologically active agent (8) immobilized to the carrier (2), said biologi...	05/27/2003
6315981	Gas filled microspheres as magnetic resonance imaging contrast agents Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided....	11/13/2001
6009342	Imaging method for the grading of tumors The endothelial integrity of microvessels is disturbed in malignant tumors. We invented a method wherein we used MRI to define tumor microvascular permeabilities and correlated these permeabilities with histologic grade in tumors. Using macromolecular MRI...	12/28/1999
5900227	Multicyclic nitrone spin trapping compositions Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or h...	05/04/1999
5827501	Use of free radicals in ESR and ESREMR imaging The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an e...	10/27/1998
5767089	Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules Compositions and processes to alleviate oxygen toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxi...	06/16/1998
5741893	Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable n...	04/21/1998
5725839	Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable n...	03/10/1998
5700448	Use of persistent free-radicals in magnetic resonance imaging The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based π-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic res...	12/23/1997
5622687	Calixarene conjugates useful as MRI and CT diagnostic imaging agents Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone, and (ii) at least one imaging moiety linked thereto, and may...	04/22/1997
5599522	Triarylmethyl radicals and the use of inert carbon free radicals in MRI A radical compound of formula Ia .C(Ar12)3 (Ia) wherein: each Ar12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar12 being a group Ar	02/04/1997
5567411	Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group Dendritic derivatives of 3,5-bis(aminomethyl)benzene and aminomethyl benzene core groups are disclosed. In each derivative, termed an "amplifier" because the dendritic structure on each molecule terminates with multiple termini to each of which an "active...	10/22/1996
5435991	Use of persistent heterocyclic free-radicals in magnetic resonance imaging The present invention provides the use of a persistent π-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising π-system of said radical comprises at least one homo or hetero...	07/25/1995
5431901	Selective isotopic labeling of spin labels for electron spin resonance spectroscopy Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramag...	07/11/1995
5407657	Hybrid magnetic resonance contrast agents Novel MRI contrast agents that comprise one or more metal-ion chelates in juxtaposition with one or more free-radical nitroxide compounds in a polymeric or oligomeric molecule. Both the chelate units and the free radical units may, independently, be insid...	04/18/1995
5403572	Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents....	04/04/1995
5362477	19F magnetic resonance imaging agents which include a nitroxide moiety Methods and compositions are disclosed for enhancing 19 F magnetic resonance imaging which utilize 19 F magnetic resonance contrast media having enhanced 19 F relaxivity. Fluorine-containing compounds having enhanced ...	11/08/1994
5358703	Method for the detection of nitric oxide A method of detecting nitric oxide in an aqueous body fluid of a mammal comprises introducing into the body fluid the agents required to form a water-soluble, stable, paramagnetic complex with nitric oxide and then subjecting the body fluid to magnetic re...	10/25/1994
5314681	Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging The invention relates to a modification of electron spin resonance enhanced magnetic resonance imaging (ESREMRI) in which two magnetically responsive materials (contrast agents) are introduced into the sample being investigated, one contrast agent serving...	05/24/1994
5264204	Hydrophilic free radicals for magnetic resonance imaging Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention incl...	11/23/1993
5256397	2,2,5,5-tetrasubstituted-pyrrolidine-1-oxyl compounds useful as MRI agents Nitroxides useful as MRI enhancing agents are of the formula ##STR1## wherein R1, R2, R3 and R4 each are alkyl of 1-4 carbon atoms; and R is --alk--COO- M+ or --B--N+ (Alk)...	10/26/1993
5252317	Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each com...	10/12/1993
5250672	Contrast agent for NMR imaging A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H2 O relaxation times in NMR diagnosis may comprise a polysaccharide to which is che...	10/05/1993
5135737	Amplifier molecules for enhancement of diagnosis and therapy Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each com...	08/04/1992
5104641	Nitroxide NMR contrast enhancing agents and their use in NMR imaging Nitroxides useful as NMR contrast enhancing agents for organs are of the formula ##STR1## wherein in the above formulae, R1, R2, R3 and R4 are, g., CH3 ; R is --B--COO--M+ or --B--N(al...	04/14/1992
4925652	Nitroxyl compounds, and diagnostic media based thereon useful for enhancing NmR imaging Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH2)n -- or , if is a single bond, also the grouping --NHCO(CH2)	05/15/1990
4863717	Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging Nitroxide contrast agents for MRI have a long useful life and can be administered in low concentration doses. Such agents include nitroxide-doped liposomes that encapsulate an oxidant and large molecules having surfaces covered with persistent nitroxide f...	09/05/1989
4845090	Nitroxyl compound and diagnostic media based thereon useful for enhancing NMR imaging Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH2)n -- or, if is a single bond, also the grouping --NHCO(CH2)	07/04/1989
4834964	Use of charged nitroxides as NMR image enhancing agents for CSF Charged, stable, organic nitroxides, e.g., charged by a quaternary ammonium or a Bronsted acid group, are useful as NMR image enhancing agents for cerebrospinal fluid....	05/30/1989
4830858	Spray-drying method for preparing liposomes and products produced thereby A method is provided for preparing a stable liposome precursor in the form of a mixture of spray-dried liposomal components including one or more biologically active compounds which may be stored dry and reconstituted with water to form a liposomal prepar...	05/16/1989
4656026	Magnetic resonance (MR) image enhancement compounds for specific areas of the brain An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compoun...	04/07/1987

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Class 424/9.33 - Nitroxide or nitroxide containing