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| Number | Title | Issue Date |
| 7998462 | Linkers for anchoring targeting ligands An improved linker which lacks chiral centers between a hydrophobic anchor for coupling to lipid-based particles and a targeting agent has suitable hydrophobic/hydrophilic properties for use in vivo. ... | 08/16/2011 |
| 7427393 | Pharmaceutical preparation containing magnetic vesicular particles, manufacturing method thereof and diagnostic therapeutic system A pharmaceutical preparation containing magnetic vesicular particles is disclosed, wherein the magnetic vesicular particles each include magnetic microparticles within a lipid membrane, an organic compound having at least two groups selected from the group consistin... | 09/23/2008 |
| 7419796 | Method of making a test device The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixtur... | 09/02/2008 |
| 7411042 | Tumor associated nucleic acids and uses therefor The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating ... | 08/12/2008 |
| 7378078 | Compositions and methods for detecting proteolytic activity The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemil... | 05/27/2008 |
| 7371511 | Polydiacetylene polymer blends Polymer blend compositions that include diacetylene segments are provided. The polymers containing diacetylene segments are capable of a calorimetric indication in response to stimuli, such as heat, an analyte or exposure to certain environmental factors, despite be... | 05/13/2008 |
| 7368129 | Amphiphilic materials and liposome formulations thereof Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moi... | 05/06/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7344698 | Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ... | 03/18/2008 |
| 7344704 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as... | 03/18/2008 |
| 7329415 | Materials containing multiple layers of vesicles The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite... | 02/12/2008 |
| 7285289 | Nanoparticle vaccines The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also displa... | 10/23/2007 |
| 7261875 | Dendritic poly (amino acid) carriers and methods of use The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have multiple functional groups at the polymer surface. In addition, they hav... | 08/28/2007 |
| 7255875 | Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ... | 08/14/2007 |
| 7244413 | Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of produci... | 07/17/2007 |
| 7235227 | Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as... | 06/26/2007 |
| 7229604 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases... | 06/12/2007 |
| 7229773 | Screening method for apoptosis-suppressing or-promoting substance To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected, also to provide an apoptosis-suppressing substance or an apoptosis-prom... | 06/12/2007 |
| 7223380 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases... | 05/29/2007 |
| 7217427 | Polymersomes and related encapsulating membranes The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile mol... | 05/15/2007 |
| 7186459 | Liposome coated with polyhydroxyalkanoate and production method thereof A structure, which has both a drug holding capability and a sustained release ability utilizing a liposome and mechanical strength of a polyhydroxyalkanoate. This structure is excellent in holding capability for hydrophilic drugs and other water-soluble substances, ... | 03/06/2007 |
| 7179449 | Enhanced ultrasound detection with temperature-dependent contrast agents Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or... | 02/20/2007 |
| 7166297 | Lipid-based drug delivery systems against parasitic infections The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment or detection of parasitic infections, especially parasitic infections... | 01/23/2007 |
| 7108863 | Liposome composition for improved intracellular delivery of a therapeutic agent A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The li... | 09/19/2006 |
| 7094424 | Cationic lipid compositions targeting angiogenic endothelial cells Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cat... | 08/22/2006 |
| 7070801 | Sugar-modified liposome and products comprising the liposome The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities, particularly in the intestine. The molecular structure and quantity of the s... | 07/04/2006 |
| 7067111 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases... | 06/27/2006 |
| 7060252 | Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of produci... | 06/13/2006 |
| 7060291 | Modular targeted liposomal delivery system A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to ... | 06/13/2006 |
| 7053210 | Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit... | 05/30/2006 |
| 7008614 | Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component: R1—CO2—R2 wherein R1 represents a substituted or unsubstituted 2,3,5-tri... | 03/07/2006 |
| 6991805 | Temperature sensitive control of liposome-cell adhesion The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At above the critical micellar temperature of the poloxamer, a fraction of t... | 01/31/2006 |
| 6991776 | Intracorporeal medicaments for high energy phototherapeutic treatment of disease New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xan... | 01/31/2006 |
| 6989153 | Radiation sensitive liposomes The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a p... | 01/24/2006 |
| 6986902 | Polyanionic polymers which enhance fusogenicity The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with ... | 01/17/2006 |
| 6979460 | Vinyl ether lipids with cleavable hydrophlic headgroups A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with tar... | 12/27/2005 |
| 6974589 | Neutral-cationic lipid for nucleic acid and drug delivery A lipid represented by the formula: wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting of (i) ... | 12/13/2005 |
| 6960560 | Iron chelator delivery system An iron chelator delivery system is disclosed. The system comprises iron chelator and a lipid carrier, e.g., a liposome. Methods for preparing and administering the iron chelator delivery system are also provided. ... | 11/01/2005 |
| 6958160 | Self forming, thermodynamically stable liposomes and their applications A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is below about 40 degrees C., and the acyl chains of the diacylglycerol-... | 10/25/2005 |
| 6936700 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hyd... | 08/30/2005 |
