Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8383085 | Methods of making iron-containing nanoparticles A method of making iron-containing nanoparticles (e.g., magnetite nanoparticles) that includes contacting an iron-containing precursor with a reducing agent at a temperature less than 200° C. and allowing the mixture to react to form magnetite nanoparticles. ... | 02/26/2013 |
| 8349293 | Use of metal nanoparticles in the diagnosis of Alzheimer's disease The invention relates to the use of metal nanoparticles for the preparation of a composition for diagnosing Alzheimer's disease by MRI. ... | 01/08/2013 |
| 8349294 | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. ... | 01/08/2013 |
| 8192721 | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents The invention relates to compositions comprising a gadolinium-based contrast agent and a derivatized cyclodextrin. Further provided are methods for reducing the toxicity associated with gadolinium-based contrast agents. ... | 06/05/2012 |
| 7871598 | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. ... | 01/18/2011 |
| 7811550 | Method for making magnetic fluorescent core shell nanoparticles This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of the nanoparticles magnetic core and fluorescent semiconductor shell. Met... | 10/12/2010 |
| 7780953 | Compositions magnetic particles covered with -bisphosphonate derivatives The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2 | 08/24/2010 |
| 7708978 | Targeted hydrophilic polymer, binders with interferon and medical composite comprising above binders The present invention relates to an active targeted water-solubility macromolecule polymer, conjugate with interferon and pharmaceutical composition comprising the conjugate. The targeted agent includes, for example, glucose, galatose and the like, as well as their ... | 05/04/2010 |
| 7666394 | Nanoparticles having reactive ester groups covalently coupled thereto and related methods A particle having a core and a surface to which are covalently coupled a plurality of reactive ester groups. Methods for using the particle to prepare a particle having one or more of a plurality of a targeting agent, a diagnostic agent, or a therapeutic agent coval... | 02/23/2010 |
| 7560097 | Pharmaceutical preparation containing magnetic vesicular particles, manufacturing method thereof and diagnostic therapeutic system A pharmaceutical preparation containing magnetic vesicular particles is disclosed, wherein the magnetic vesicular particles each include magnetic microparticles within a lipid membrane, an organic compound having at least two groups selected from the group consistin... | 07/14/2009 |
| 7459145 | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The p... | 12/02/2008 |
| 7407646 | Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic i... | 08/05/2008 |
| 7367934 | Methods of enhancing radiation effects with metal nanoparticles The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can... | 05/06/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7351194 | Arrangement for influencing magnetic particles An arrangement for influencing magnetic particles in a region of action with the help of an arrangement for generating magnetic fields, by which there is generated a spatially inhomogeneous magnetic field having at least one zone in which the magnetization of the pa... | 04/01/2008 |
| 7338651 | Multi-use multimodal imaging chelates Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester ... | 03/04/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7309316 | Magnetic needle biopsy An apparatus and method for performing biopsies in-vivo using magnetically labeled nanoparticles is disclosed. One embodiment of the apparatus is called a magnetic needle. When used in a biopsy, one embodiment of the present invention collects cancer cells in-vivo w... | 12/18/2007 |
| 7300452 | Method for local heating by means of magnetic particles The invention relates to a method as well as to a system for the local heating of a target region of an object by varying the magnetization of magnetic or magnetizable substances. A magnetic field is then generated whose magnetic field strength varies in space in su... | 11/27/2007 |
| 7279150 | Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ... | 10/09/2007 |
| 7276254 | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same A method of forming polymeric microspheres for biomedical applications includes forming polymeric microspheres by an emulsion/aggregation process from a precursor monomer species, and treating the polymeric microspheres to attach a biomedical functional material to ... | 10/02/2007 |
| 7255875 | Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ... | 08/14/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7249604 | Medical devices for occlusion of blood flow The present invention discloses a method for the occlusion of blood vessels or fluid vessels to stop the flow of blood or fluid during elective or emergency surgical procedures or following traumatic injury. This invention also encompasses a medical device or tool f... | 07/31/2007 |
| 7244413 | Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of produci... | 07/17/2007 |
| 7241399 | Synthesis of nanoparticles Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield com... | 07/10/2007 |
| 7235227 | Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as... | 06/26/2007 |
| 7235228 | Fluorescent-magnetic nanoparticles with core-shell structure This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of the nanoparticles magnetic core and fluorescent semiconductor shell. Met... | 06/26/2007 |
| 7220401 | Blood clot-targeted nanoparticles Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further incl... | 05/22/2007 |
| 7208134 | Bioprocesses enhanced by magnetic nanoparticles One aspect of the present invention relates to magnetic nanoparticles colloidally stabilized in aqueous milieu by association with an organic phase. The organic phase may be either a fluorinated polymer or an organic hydrocarbon bilayer, wherein the two layers are c... | 04/24/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7186399 | Methods for targeted drug delivery A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c)... | 03/06/2007 |
| 7179449 | Enhanced ultrasound detection with temperature-dependent contrast agents Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or... | 02/20/2007 |
| 7179450 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 02/20/2007 |
| 7179660 | Carriers coated with polysaccharides, their preparation and use A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spo... | 02/20/2007 |
| 7181266 | Materials and methods for near-infrared and infrared lymph node mapping A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the near infrared. ... | 02/20/2007 |
| 7163935 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 01/16/2007 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
| 7106892 | Display of image data information A method and workstation for producing a combined image, including information from first and second diagnostic images, identify areas of increased uptake in the second diagnostic image as a region of interest which contains pixels representing the areas of increase... | 09/12/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
