Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8163270 | Methods of diagnosing and treating migraine The present invention provides methods of diagnosing migraine attacks and determining predisposition of an individual to the development of migraine based on sodium level in the cerebrospinal fluid (CSF) and/or brain extracellular fluid. The invention also provides ... | 04/24/2012 |
| 8147802 | Chelator-functionalized nanoparticles Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also provided are methods of making such chelator-functionalized nanoparticle... | 04/03/2012 |
| 8128907 | CSF biomarker dilution factor corrections by MRI imaging and algorithm A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anat... | 03/06/2012 |
| 8084017 | Contrast agents for magnetic resonance imaging and methods related thereto In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are generated in situ via genetic instructions and become potent upon sequest... | 12/27/2011 |
| 8066973 | Nanoparticulate probe for in vivo monitoring of tissue oxygenation A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. A... | 11/29/2011 |
| 8003077 | Method for the production of hyperpolarized Xe The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent. ... | 08/23/2011 |
| 7993628 | Higher fatty acid triester and amide derivative having diethylenetriamine-type metal chelate structure A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R1 to R3 represent an alkyl group o... | 08/09/2011 |
| 7968082 | Evaluating mixtures of low molecular weight heparins by NMR Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR. ... | 06/28/2011 |
| 7871597 | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatib... | 01/18/2011 |
| 7867477 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 01/11/2011 |
| 7842281 | Magnetic particle composition for therapeutic hyperthermia Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature ... | 11/30/2010 |
| 7820143 | Water soluble tetrapyrollic photosensitizers for photodynamic therapy A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a... | 10/26/2010 |
| 7811549 | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects Methods are presented that comprise the administration of a pharmaceutical composition comprising adenosine and dipyridamole, as well methods comprising the combined administration of dipyridamole administered as a bolus with adenosine given as an infusion, both at ... | 10/12/2010 |
| 7803352 | Method for continuous visualization of a blood clot or plaque in body lumen A method for visualizing a blood clot or plaque disposed within a body lumen comprising: binding a contrasting complex comprising a contrast material and a thrombolytic material or a clot dissolving agent to the blood clot or plaque; and visualizing the blood clot o... | 09/28/2010 |
| 7780952 | Agents for magnetic imaging method The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer.... | 08/24/2010 |
| 7744854 | Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to ide... | 06/29/2010 |
| 7736623 | CSF biomarker dilution factor corrections by MRI imaging and algorithm A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anat... | 06/15/2010 |
| 7713516 | Method for determining suitability of various contrast agents for the imaging examination of the patient and uses of the ligand contained in a selected contrast agent A method is for determining suitability of various contrast agents for the imaging examination of the. In this case, a tissue sample is taken from the patient, it is divided into a plurality of individual samples and a contrast agent which binds to a particular targ... | 05/11/2010 |
| 7700075 | Virtual colonoscopy with radiolabeled phospholipid ether analogs The present invention provides agents and methods for dual modality virtual colonoscopy that gives both anatomical and functional information using hybrid CT/PET scanning. In preferred embodiments, the present invention provides radiolabeled tumor-specific agents an... | 04/20/2010 |
| 7662362 | Nanoparticulate probe for in vivo monitoring of tissue oxygenation A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative co... | 02/16/2010 |
| 7622102 | Method for monitoring early treatment response Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the tissue adjoining or surrounding the cancerous tissue befo... | 11/24/2009 |
| 7560096 | Diagnostic procedures using direct injection of gaseous hyperpolarized Xe and associated systems and products A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled manner such that the gas substantially dissolves in... | 07/14/2009 |
| 7553479 | Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamag... | 06/30/2009 |
| 7459144 | Process for preparation of MR contrast agents The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogen... | 12/02/2008 |
| 7438894 | Dyes for organ function monitoring Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 10/21/2008 |
| 7438893 | Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 10/21/2008 |
| 7427391 | Formulations for use in medical and diagnostic procedures The present invention relates to formulations for use in medical or diagnostic procedures comprising a stabilizing agent alone or in combination with an osmotic agent. In one embodiment, the stabilizing agent is a natural hydrocolloid, preferably locust bean gum, an... | 09/23/2008 |
| 7419654 | Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the para... | 09/02/2008 |
| 7410634 | Tissue metabolic stress monitoring Various pathophysiological states are determined by evaluating the rate of 17O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke ... | 08/12/2008 |
| 7412279 | Systems and methods for targeted magnetic resonance imaging of the vascular system This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Me... | 08/12/2008 |
| 7407646 | Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic i... | 08/05/2008 |
| 7385041 | Dual functioning excipient for metal chelate contrast agents A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient, Xm[X′(L′)]n, which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safet... | 06/10/2008 |
| 7385395 | Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improv... | 06/10/2008 |
| 7373782 | Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life produ... | 05/20/2008 |
| 7371365 | Methods for detecting parenchymal plaques in vivo Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amy... | 05/13/2008 |
| 7368254 | Lipid-based systems for targeting diagnostic agents The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from increased levels of extracellular PLA2 activity in the di... | 05/06/2008 |
| 7368910 | Dual gradient echo pulse sequence using interleaved spiral-out spiral-in k-space trajectories Measurements of functional, hemographic, and blood flow parameters use a multiple echo or spin echo gradient pulse sequence whereby an early echo is acquired near the beginning of the pulse sequence which avoids saturation effects and a later echo near the end of th... | 05/06/2008 |
| 7368099 | MRI contrast agents An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signal... | 05/06/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7362840 | Circuit and method for adjusting timing alignment using programmable codes A method is provided for adjusting timing alignment in which a receiver generates a plurality of imbalanced correction codes (1310), and square waves both having the same frequency. The receiver mixes the imbalanced correction codes with the square waves to c... | 04/22/2008 |
