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| Number | Title | Issue Date |
| 8182790 | Contrast agents A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding... | 05/22/2012 |
| 8168160 | Anti-inflammatory fusion protein The present invention relates to a fusion protein comprising therapeutic and diagnostic potential against chronic vascular diseases, such as atherosclerosis, a nucleic acid molecule encoding said fusion protein, a pharmaceutical and diagnostic composition which comp... | 05/01/2012 |
| 8158107 | Genes and proteins associated with angiogenesis and uses thereof Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying compounds useful for regulating angiogenesis and conditions related th... | 04/17/2012 |
| 8138143 | Methods for treating a neurological disorder by peripheral administration of a trophic factor The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor c... | 03/20/2012 |
| 8124055 | Compositions and methods to control angiogenesis with cupredoxins The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the p... | 02/28/2012 |
| 8119103 | Bifunctional resorcinol, thioresorcinol, and dithioresorcinol derivative metal chelating conjugates The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostic or therapeutic agents. Specifically, conjugates of the present invention include one or more carriers, a linker, and metal coordinating moiety comprising a re... | 02/21/2012 |
| 8119104 | Treatment of celiac disease with IgA A process for inhibiting symptoms of a subject with celiac disease is provided that includes administration of monoclonal-, or polyclonal-, monomeric, dimeric, or polymeric IgA. Joining secretory component to the IgA limits oral administration degradation. Formulati... | 02/21/2012 |
| 8114382 | Myelin detection using benzofuran derivatives The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifyi... | 02/14/2012 |
| 8114838 | Methods for protecting dopaminergic neurons from stress and promoting proliferation and differentiation of oligodendrocyte progenitors by NRG-2 The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel NRG-2 polypeptides and nucleic acid molecules. ... | 02/14/2012 |
| 8101158 | Methods for treating cerebrovascular disease comprising administering an agent that inhibits prokineticin receptor activity The present invention relates to a method of identifying agents that modulate prokineticin receptors, particularly, in the brain. Such agents are useful in the treatment of cerebrovascular diseases, including cerebral ischemia, cerebral hemorrhage, ischemic stroke, ... | 01/24/2012 |
| 8101157 | Ligands to radiation-induced molecules A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse mo... | 01/24/2012 |
| 8088358 | Paramagnetic nanoparticle The present invention relates to the preparation and use of nanoparticles, in particular paramagnetic nanoparticles, and their use as contrast enhancers for NMR-based methods of examination. A significant increase in contrast (e.g. from 100 to 200%) takes place acco... | 01/03/2012 |
| 8088359 | Means and methods of using a NADPH oxidase inhibitor for the treatment of hearing loss and phantom hearing This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the step... | 01/03/2012 |
| 8084016 | Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible ... | 12/27/2011 |
| 8057783 | Method of injecting liquid agents at acupuncture points to arrive internal organs and method of visualizing arrival of liquid agents Provided are a method of injecting a visualizing material into a point in the vicinity of the Jung-Wan and a method of visualizing arrival of liquid agent in order to verify that the visualizing material injected arrives at internal organs. A point having the lowest... | 11/15/2011 |
| 8048405 | Radioactive mixture and manufacturing method thereof A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with Tc... | 11/01/2011 |
| 8043603 | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue. ... | 10/25/2011 |
| 8043602 | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue. ... | 10/25/2011 |
| 8038986 | Immunogenic compositions and diagnostic and therapeutic uses thereof The present invention relates to a method of inducing an immune response to a parasite utilizing an immunogenic composition comprising a glycosylphosphatidylinositol (“GPI”) inositolglycan domain or its derivative or equivalent. The present invention is useful a... | 10/18/2011 |
| 8029764 | Methods for detection of colorectal cancer Particular genes are aberrantly and consistently expressed in both adenomas and carcinomas of the colon. Products of such genes provide stool and serum markers for colorectal neoplasia. One particular tumor marker, Renal Dipeptidase (RDP), is expressed at high level... | 10/04/2011 |
| 8029765 | SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used fo... | 10/04/2011 |
| 8025866 | Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen Fh8 (fasciolin) Fasciolosis is an anthropozoonotic disease caused by the Trematoda Fasciola hepatica. This worm is a common parasite of ruminants namely sheep, goats and cattle. Adult worms are usually found in the bile ducts of the final host liver, causing significant econ... | 09/27/2011 |
| 8017104 | Large stoke shift dye used for optical imaging The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relate... | 09/13/2011 |
| 8017103 | Methods and compositions to diagnose infection The present invention provides methods and compositions for diagnosing Trichomonas infection by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample from a subject. ... | 09/13/2011 |
| 8012456 | Biological models capable of exhibiting secondary disease manifestations and useful for developing therapeutic drugs, diagnostic products and therapeutic or diagnostic procedures, methods of using same, and cells, tissues and organs derived therefrom This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by this invention which are capable of exhibiting analogous secondary dise... | 09/06/2011 |
| 8012457 | Ultrasound contrast agent dosage formulation Clinical studies have been conducted and specific dosage formulations developed using polymeric microparticles having incorporated therein perfluorocarbon gases that provide significantly enhanced images of long duration. The dosage formulation includes microparticl... | 09/06/2011 |
| 8007769 | Method for diagnosing an increased risk of preeclampsia by measuring the level of HIF-α Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β3, receptors of cytokines of the TGβ family, or HIF-1α. ... | 08/30/2011 |
| 7993627 | Methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≧41) alone or in combination with Aβ(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ(x≦40) and Aβ(... | 08/09/2011 |
| 7985402 | Targeting vector-phospholipid conjugates Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly usefu... | 07/26/2011 |
| 7981399 | Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium The present invention relates to a method for determining the ideal time for and outcome of reproductive health procedures including in vitro fertilization by establishing a correlation between the successful outcome of said procedure and the spectra of a body fluid... | 07/19/2011 |
| 7964177 | Method for determination of oxidative stress Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of v... | 06/21/2011 |
| 7947254 | Method of detecting a neuromyelitis optica specific-autoantibody by an antigenic aquaporin-4 polypeptide The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO). ... | 05/24/2011 |
| 7922999 | Administration of growth factors for the treatment of CNS disorders A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described. ... | 04/12/2011 |
| 7910087 | Luciferins Novel luciferins, methods of making luciferins, and uses of the same are disclosed. ... | 03/22/2011 |
| 7879314 | Optical imaging of rheumatoid arthritis The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out t... | 02/01/2011 |
| 7871596 | Higher fatty acid triester compound having diethylenetriamine-type metal chelate structure A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R1,... | 01/18/2011 |
| 7867476 | Method and materials for use in diagnosing viral myocarditis The invention consists of assay methods, assay kits and antibodies for detecting the polypeptide fragments of dystrophin protein cleavage by enteroviral protease 2A as a result of an enteroviral infection in the heart. The presence of dystrophin cleavage products in... | 01/11/2011 |
| 7862798 | Vitamin-targeted imaging agents The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. T... | 01/04/2011 |
| 7862799 | Antibody production method A method of inducing the sustained release of antibodies in milk comprising the step of: a) implanting at least one antigen releasing device adjacent to, within close proximity of or within at least one supramammary lymph node, wherein in use the antigen releasing d... | 01/04/2011 |
| 7858072 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 12/28/2010 |
