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| Number | Title | Issue Date |
| 8182803 | C-terminally truncated interferon alpha variants The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length human α-2b-interferon. It is the novel finding of the present inventio... | 05/22/2012 |
| 8137661 | Controlled release interferon drug products and treatment of HCV infections using same The invention relates to controlled release formulations comprising a microparticle comprising a biodegradable polymer and one or more interferon compounds and methods of using the formulations. ... | 03/20/2012 |
| 8119116 | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially direc... | 02/21/2012 |
| 8114395 | Treatment of viral diseases with recombinant interferon α This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and can... | 02/14/2012 |
| 8110182 | Treatment of multiple sclerosis by administration of interferon alpha and C-phycocyanin The present invention consists of the combination of Interferon alpha and C-Phycocyanin (IFN-α/C-Phyco) for obtaining a pharmaceutical preparation for autoimmune disease, allergy and cancer treatments. The anti-inflammatory, immunomodulator, antioxidant, anti-viral... | 02/07/2012 |
| 7993639 | Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent a... | 08/09/2011 |
| 7959910 | C-terminally truncated interferon alpha variants The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length human α-2b-interferon. It is the novel finding of the present inventio... | 06/14/2011 |
| 7923004 | 4-ethynyl pyrazole derivative compounds and methods for treatment of HCV Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additiona... | 04/12/2011 |
| 7919078 | Recombinant interferon α2 (IFNα2) mutants and methods of use thereof The present invention provides IFNα2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, and methods utilizing the same for treating cancer, infectious diseas... | 04/05/2011 |
| 7867482 | Recombinant human interferon-like proteins This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human ... | 01/11/2011 |
| 7829077 | Treatment of hepatitis C with compositions comprising oncostatin M and interferon alpha The invention relates to the use of at least one cytokine from the IL-6 family -gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, ciliary neurotrophic factor (CNTF), the cardiotrophin-like cytoki... | 11/09/2010 |
| 7790153 | Method of treating rheumatoid arthritis using orally administered type one interferons The present invention provides a method of treating auto-immune diseases in an animal comprising the step of orally administering a type one interferon to said animal. Also provided is a method of reducing inflammation associated with an auto-immune disease in an an... | 09/07/2010 |
| 7744867 | PTPase inhibitors and method of using same The various embodiments of the present invention are directed to pentavalent antimonials, purified pentavalent antimonials, and pentavalent antimonials that are comprised of an antimonial portion and an organic moeity portion. Alternatively the present invention is ... | 06/29/2010 |
| 7731949 | 4-ethynyl pyrazole derivative compounds and methods for treatment of HCV Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additiona... | 06/08/2010 |
| 7695710 | Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described for use in combination therapies with antiviral and/or antitumor agents. In one embodiment, the IFNÎ... | 04/13/2010 |
| 7678774 | Treating severe acute respiratory syndrome Severe acute respiratory syndrome is treated with a natural human alpha interferon, a dsRNA or both natural human alpha interferon and a dsRNA. ... | 03/16/2010 |
| 7662370 | Low-toxicity, long-circulating human interferon-alpha PEGylated mutants Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described. In one embodiment, the IFNα analog protein has an amino acid sequence that differs from a native h... | 02/16/2010 |
| 7625555 | Recombinant human interferon-like proteins This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human ... | 12/01/2009 |
| 7611700 | Protease resistant modified interferon alpha polypeptides Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational method for generating protein variants and the resulting variants. | 11/03/2009 |
| 7537755 | Interferon-alpha polypeptides and conjugates The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polype... | 05/26/2009 |
| 7504097 | Interferon-alpha polypeptides and conjugates The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polype... | 03/17/2009 |
| 7488473 | Interferon-alpha polypeptides and conjugates The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polype... | 02/10/2009 |
| 7431920 | Method of treating IL-10 deficiency A method for treating an IL-10 deficiency in a human subject is described, where a person having an IL-10 deficiency is identified and treated with interferon-tau (IFNÏ„) at a dose sufficient to increase the IL-10 level. ... | 10/07/2008 |
| 7416723 | Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent a... | 08/26/2008 |
| 7402305 | Polypeptides of the IFNα-21 gene Polynucleotides and polypeptides derived from the nucleotide sequence of the IFNα-21 gene comprising SNPs, and their therapeutic uses. ... | 07/22/2008 |
| 7399464 | Polypeptides of the IFNα-7 gene The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFNα-7 gene comprising new SNPs, and new polypeptides derived from the wild-type IFNα-7 protein comprising at least one mutation caused by at least one SNP of the inve... | 07/15/2008 |
| 7371819 | Polypeptides of the IFNα-17 gene The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFNα-17 gene comprising new SNPs, and new polypeptides derived from the natural wild-type IFNα-17 protein comprising at least one mutation caused by at least one SNP o... | 05/13/2008 |
| 7371372 | Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor selected from VX-148 or VX-944, wherein the IMPDH inhibitor is presen... | 05/13/2008 |
| 7364724 | Recombinant super-compound interferon This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and can... | 04/29/2008 |
| 7358333 | Polypeptides of the IFNα-5 gene The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFNα-5 gene comprising new SNPs, and new polypeptides derived from the natural wild-type IFNα-5 protein comprising at least one mutation caused by at least one SNP of ... | 04/15/2008 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7338654 | Glycosylated interferon alpha obtained from a transgenic chicken This invention includes compositions comprising glycosylated human interferon-α derived from a chicken. ... | 03/04/2008 |
| 7323164 | Use of interleukin-24 to treat ovarian cancer The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, trea... | 01/29/2008 |
| 7319092 | Methods of suppressing microglial activation Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS ... | 01/15/2008 |
| 7318931 | Sustained release formulation A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in contact with an organic solvent. The polyol may be a hydrocarbon containing two or more hydroxyl groups (—OH) ... | 01/15/2008 |
| 7314613 | Interferon-alpha polypeptides and conjugates The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polype... | 01/01/2008 |
| 7311903 | Glycosylated human interferon alpha isoform The present invention relates to an amino acid-modified human interferon alpha isoform having at least one of the Asn-Xaa-Ser/Thr (N-X-S/T) sequence formed at a specific site so that glycosylation takes place at this site and a gene encoding the same, an expression ... | 12/25/2007 |
| 7294332 | Combination therapy (temozolomide and α-IFN) for advanced cancer There is disclosed a method for treating advanced cancer in patients in need of such treating. Temozolomide and alpha interferon are administered in combination in amounts sufficient to achieve a clinical response. ... | 11/13/2007 |
| 7285631 | Human cDNAs and proteins and uses thereof The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be use... | 10/23/2007 |
