Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 4474753 | Topical drug delivery system utilizing thermosetting gels This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.... | 10/02/1984 |
| 4474751 | Ophthalmic drug delivery system utilizing thermosetting gels This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a d... | 10/02/1984 |
| 4465622 | Method for purifying interferon A method for purifying interferon having anti-cancer effects or anti-viral effects, wherein highly purified interferon can be easily obtained by a single operation in a recovery of about 100%. In this method, interferon is obtained by specifically adsorbi... | 08/14/1984 |
| 4426323 | Selected recovery of proteins from fermentation broths A process is described for the selective recovery and/or concentration of a protein or a class of proteins from fermentation broth employing a combination of desalting and pH adjustment thereby causing the initial precipitation of unwanted proteins, again... | 01/17/1984 |
| 4414147 | Methods of decreasing the hydrophobicity of fibroblast and other interferons A method for improving the stability and usefulness of interferon, including human fibroblast interferon, is disclosed. In this method, interferon is bonded to a non-hydrophobic substance to create a molecular complex that is less hydrophobic than untreat... | 11/08/1983 |
| 4414204 | Antibiotic preparations having increased effectiveness, processes for their manufacture and method for increasing the antibiotic action of antibiotics The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. ##... | 11/08/1983 |
| 4394372 | Process for making lipid membrane structures A process for producing lipid membrane structures (vesicles or liposomes) is disclosed, wherein a solution of bilayer forming compounds in a narrowly-defined two component solvent system is dispersed in an aqueous solution and, subsequently, at least a po... | 07/19/1983 |
| 4377567 | Lipid membrane drug delivery Lipid Membrane Structures comprising Digalactosyl Diglyceride target the liver of humans and lower animals and are used to carry drugs to that organ, preferentially. Digalactosyl Diglyceride LMS containing insulin provide an effective means for treating d... | 03/22/1983 |
| 4343735 | Process for the purification of interferon The invention concerns a process for the purification of interferon, where interferon is purified by partitioning interferon in an aqueous multi-phase system in the presence of ion exchangers that are soluble in this system and that are derivatives of pol... | 08/10/1982 |
| 4343736 | Process for recovering interferon A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub... | 08/10/1982 |
| 4315852 | Extraction of interferon from bacteria A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second susp... | 02/16/1982 |
| 4309415 | Method and composition for treating inflammatory disorders Compositions and use of γ-linolenic acid and related materials with (i) zinc, ଲ-lactam antibiotics or other materials enhancing physiological 1-series PG synthesis and/or (ii) colchicine, Vinca alkaloids or other materials enhancing physiological s... | 01/05/1982 |
| 4262090 | Interferon production Method for preparing interferon, mRNA for interferon, and competent recombinant DNA containing dsDNA and cDNA from mRNA coding for mammalian interferon. The method employs crossing a mutant mammalian cell which is semiconstitutive for interferon with a ce... | 04/14/1981 |
| 4198479 | Replacement of animal serum proteins by human albumin for growth and interferon production by Namalva cells The invention provides an improved process for the growth of lymphoblastoid cells in a medium supplemented with human albumin. The invention further provides for the production of interferon by viral infection of these lymphoblastoid cells in a medium als... | 04/15/1980 |
| 4172071 | Chromophore blue adsorbent method for the purification of preparations having an interferon type activity The invention relates to a process for the purification of preparations having an interferon type-activity which comprises contacting the crude preparations with an adsorbent comprising as ligand a chromophore blue, equilibrated with an aqueous buffer who... | 10/23/1979 |
| 4100150 | Stabilization of interferon against mechanical stress using thioctic acid The present invention encompasses a method for stabilizing interferon during purification, concentration, packaging, filtering and storage comprising treating an interferon preparation with an effective stabilizing amount of reduced glutathione, thiodigly... | 07/11/1978 |
| 4061538 | Enzymatically oxidizing interferon The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons are useful as anti-viral agents.... | 12/06/1977 |
| 4041152 | Pharmaceutical formulation of interferon insolubilized by fixation on a support A pharmaceutical product consists of interferon which has been rendered insoluble by being coupled to a support, such as sepharose.... | 08/09/1977 |
| 4017600 | Reactivation of interferon An aqueous interferon solution wherein the interferon has lost at least part of its initial activity is reactivated by treatment with a combination of (a) an agent for disrupting non-covalent bonds, (b) an agent for reducing disulfide bridges, and (c) an ... | 04/12/1977 |
| 3981991 | Stabilization of interferon An aqueous interferon solution is stabilized by treatment with a combination of (a) an agent for disrupting non-covalent bonds, (b) an agent for reducing disulfide bridges, and (c) an anionic or cationic surface-active agent.... | 09/21/1976 |
| 3970749 | Interferon production Animal tissue is trypsinized to form a cell suspension which is placed in a nutrient medium with a virus. Produced interferon is centrifugally separated, acidified and stored at a low temperature to inactivate the virus. It may then be frozen until it is ... | 07/20/1976 |
