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| Number | Title | Issue Date |
| 6753166 | IL-1 eta DNA and polypeptides The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides... | 06/22/2004 |
| 6749847 | Hybrid cytokine of IL-7 and β-chain of hepatocyte growth factor A hybrid cytokine comprising the B-chain of hepatocyte growth factor and IL-7, linked by a linker molecule, having pre-pro-B growth stimulating activity. ... | 06/15/2004 |
| 6746670 | Regulatory T cells; methods Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described. ... | 06/08/2004 |
| 6746669 | Method for down-regulating IL5 activity The present invention relates to improvements in therapy and prevention of conditions characterized by an elevated level of eosinophil leukocytes, i.e. conditions such as asthma and other chronic allergic diseases. A method is provided for down-regulating interleuki... | 06/08/2004 |
| 6737513 | Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof Also provided are materials and methods for the recom... | 05/18/2004 |
| 6733764 | Immunostimulator anti-cancer compounds and methods for their use in the treatment of cancer The present invention comprises a method for the treatment of cancerous tumors in mammals comprising the administration of an effective amount of an immunostimulator which enhances and potentiates the mammals own immune system to selectively attack and kill the canc... | 05/11/2004 |
| 6730303 | Fused G-CSF and IL-3 proteins and uses thereof Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the mu... | 05/04/2004 |
| 6723832 | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. ... | 04/20/2004 |
| 6723314 | Use of interleukin-11 to treat gastrointestinal disorders The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed. ... | 04/20/2004 |
| 6719969 | Treatment of liver disease and injury with CXC chemokines Disclosed is the surprising discovery that CXC chemokines function to induce rapid hepatocyte proliferation and liver regeneration after injury. The invention thus provides a range of compositions and methods for use in treating liver injury, including those suitabl... | 04/13/2004 |
| 6716422 | Vaccine adjuvants for immunotherapy of melanoma The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surp... | 04/06/2004 |
| 6713053 | Use of IL-7 for treating auto-immune diseases and insulin-dependent diabetes mellitus in particular The use of interleukin 7 or T cells pre-incubated in the presence of IL-7 for preparing a drug or pharmaceutical composition for treating an auto-immune disease, particularly an auto-immune disease induced by a defect in CD4+ T cell immunoregulation, is disclosed. | 03/30/2004 |
| 6709661 | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or ... | 03/23/2004 |
| 6709658 | Pneumococcal vaccines formulated with interleukin-12 This invention pertains to vaccine compositions comprising a mixture of antigen, such as a pneumococcal or meningococcal antigen, and interleukin IL-12, which may be adsorbed onto a mineral in suspension. The pneumococcal or meningococcal antigen may be conjugated t... | 03/23/2004 |
| 6706708 | Cytotoxic agents comprising taxanes and their therapeutic use A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking gro... | 03/16/2004 |
| 6706264 | Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit... | 03/16/2004 |
| 6706261 | Compositions and methods comprising immunogenic muteins of interleukin-6 Cytokines, including muteins thereof, which are biologically inactive in humans but remain immunogenic, are used in pharmaceutical compositions to promote a neutralizing immune response against native cytokines when administered to a subject in need thereof to treat... | 03/16/2004 |
| 6699467 | Compounds and compositions for delivering active agents Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modif... | 03/02/2004 |
| 6699466 | IL-16 antagonist peptides and DNA encoding the peptides The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting pe... | 03/02/2004 |
| 6689755 | Method of stabilizing biologically active substances The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous produ... | 02/10/2004 |
| 6689353 | Stabilized interleukin 2 A stable pharmaceutical preparation comprising Human interleukin-2 or a variant thereof and a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose and a variant of IL-2 having a single mutation, N88R. The preferred formula... | 02/10/2004 |
| 6685932 | Coiled-coil dimer derived antagonists of 4-helix bundle cytokines, design and uses thereof The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.... | 02/03/2004 |
| 6685931 | Treatment of hepatitis C virus infections with interleukin-10 The hepatoprotective effect of IL-10 is described, in particular, the use of interleukin-10 in the treatment of liver damage (e.g. fibrosis or cirrhosis) in a difficult-to-treat patient afflicted with chronic hepatitis C virus infection who has failed to ... | 02/03/2004 |
| 6685930 | Methods and substances for recruiting therapeutic agents to solid tumors Disclosed is a method of using bifunctional binding molecules, such as two linked VH -VL single chain binding molecules, to recruit a therapeutic agent to a solid tissue site. The therapeutic agent is administered separately from the... | 02/03/2004 |
| 6683046 | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergisticall... | 01/27/2004 |
| 6680057 | Methods of treating autoimmune disease by administering interleukin-17 receptor Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.... | 01/20/2004 |
| 6669938 | ImmunoConjucates for cancer diagnosis and therapy Immunoconjugates of an antibody to a 22 KD breast tumor associated antigen were prepared. Cytotoxic immunoconjugates such as gelonin-15A8 antibody conjugate are useful for treating proliferative cell diseases such as breast carcinoma and cervical carcinom... | 12/30/2003 |
| 6669934 | Method of modulating fertility in animals by IL-11 The present invention relates to a method for modulating fertility in an animal by administering an effective amount of IL-11 or derivatives or homologues thereof or an effective amount of an agonist or antagonist of the interaction between IL-11 and IL-1... | 12/30/2003 |
| 6663878 | Anti-inflammatory bioactive glass particulates Compositions and methods for systemically minimizing the inflammatory effects of TNF- are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20 μm, alone or in combination with anti-inflammatory a... | 12/16/2003 |
| 6663859 | Compositions for enhancing the immune response D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration of D-Ribose. Methods are also provided for the enhancemen... | 12/16/2003 |
| 6660258 | Oromucosal cytokine compositions and uses thereof Pharmaceutical compositions for oromucosal; contact to stimulate host defense mechanisms in a mammal, having an effective amount of Th1 or Th2 stimulating cytokine, and methods of treatment with such compositions are provided.... | 12/09/2003 |
| 6656462 | Interleukin-1 muteins useful as vaccine adjuvants The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example, muteins of IL-1ଲ can be used according to the inven... | 12/02/2003 |
| 6645486 | Method of treatment with IL-9 conjugate The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.... | 11/11/2003 |
| 6638517 | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania an... | 10/28/2003 |
| 6632456 | Compositions for inhalation A pharmaceutical composition including a mixture of active compounds (A) a pharmaceutically active polypeptide, and (B) an enhancer compound which enhances the systemic absorption of the polypeptide in the lower respiratory tract of a patient, the mixture... | 10/14/2003 |
| 6630576 | Amino acid substitution mutants of interleukin 13 This invention provides mutant hIL13 molecules include those made by substituting one or more of the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Multiply mutated forms of hIL13 conjugat... | 10/07/2003 |
| 6623472 | Method for inducing therapeutically-effective proteins A method for inducing therapeutically-effective protein includes selecting a syringe having inner structures coated with an inductor, disposing a therapeutically-effective protein therein with a body fluid and incubating the syringe and its contents. The ... | 09/23/2003 |
| 6623731 | Compounds and compositions for delivering active agents Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and method... | 09/23/2003 |
| 6620590 | Diagnosis of pre-eclampsia A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis and can be used to predict the onset of secondary symptoms... | 09/16/2003 |
| 6613337 | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania an... | 09/02/2003 |
