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Class 424/85.2 - Interleukin


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the immune mediator is a macrophage
No. of patents: 1096
Last issue date: 05/15/2012


                    28  
NumberTitleIssue Date
4490289Homogeneous human interleukin 2
Human interleukin 2 (IL-2) derived from induced human malignant cells has been purified to homogeneity using multiple high performance liquid chromatography (HPLC) steps. The purified IL-2 exhibits potent activity promoting the long-term in vitro culture ...
12/25/1984
4473642Constitutive production of interleukin 2 by a T cell hybridoma
A process for constitutively producing murine IL-2 from hybridoma cells generated by fusing mitogen stimulated malignant murine cells with drug sensitive murine thymoma driver cells. A fusing agent is used to fuse the two parent cells together. After fusi...
09/25/1984
4464355Serum-free and mitogen-free T-cell growth factor and process for making same
A serum-free and mitogen-free T-cell growth factor which is effective in stimulating natural killer cell function in tumor patients is provided. A method of producing the growth factor from human, bovine or porcine spleen or blood is described....
08/07/1984
4457916Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
A method for stabilizing Tumor Necrosis Factor (TNF), which comprises adding a stabilizing agent selected from a nonionic surfactant, at least one substance selected from the group consisting of D-glucose, D-galactose, D-xylose, D-glucuronic acid, a salt ...
07/03/1984
4448879High yield process for in vitro production of serum-free and mitogen-free interleukin-2
An improved in vitro cell culture process for producing in high yield and purity a serum-free and mitogen-free interleukin-2-containing conditioned supernatant. The incubation steps during stimulation and conditioning of the interleukin-2 producing cells ...
05/15/1984
4447355Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same
A method for stabilizing a Tumor Necrosis Factor (TNF), which comprises adding at least one member selected from the group consisting of an albumin, a gelatin, a globulin, a protamine and a salt of protamine to an aqueous solution or powder containing TNF...
05/08/1984
4438032Unique T-lymphocyte line and products derived therefrom
Human T-lymphoblast cell line, Proteinaceous products produced therefrom, messenger RNA and DNA expressing the proteinaceous products. A human T-lymphoblast cell line (Mo) maintained as a continuous culture constitutively produces proteins, including immu...
03/20/1984
4420395Blood purification device
Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 μmole/m2 of the silanol group on the surface thereof, a blood inlet and a blood out...
12/13/1983
4411993Hybridoma antibody which inhibits interleukin 2 activity
A process for producing anti-IL-2 antibody from hybridoma cells generated by fusing activated, IL-2 immunized, murine lymphocyte cells with neoplastic murine myeloma cells. Fusion is accomplished by mixing the two cell lines together in the presence of a ...
10/25/1983
4406830Regulatory glycoprotein for immune response and the use thereof in the production of T-cell growth factor
A cell mediated immune response system glycoprotein having a molecular weight of about 90,000 and having at least one sialic acid moiety as a biologically active site is disclosed. The glycoprotein is specifically bound by wheat germ agglutinin and also b...
09/27/1983
4404280Process for preparing murine interleukin 2 in the presence of interleukin 1 from an interleukin 2 nonproducer malignant cell line and cell line therefor
A process for producing murine IL-2 from malignant neoplastic cells which are incapable of IL-2 production by mitogen stimulation alone includes culturing murine leukemia or lymphoma cells in vitro in a protein-containing medium supplemented with various ...
09/13/1983
4401756Process for preparing human interleukin 2
A process for preparing IL-2 from human malignant cells includes culturing human leukemia or lymphoma cells in vitro in a serum containing medium supplemented with various additives. The culture is stimulated by an optimum concentration of a T cell mitoge...
08/30/1983
4390623Serum-free and mitogen-free T-cell growth factor and process for making same
A serum-free and mitogen-free T-cell growth factor (interleukin-2) preparation is prepared from human, bovine, or procine peripheral mononuclear blood cells which are washed several times with a liquid tissue culture medium and then stimulated in a tissue...
06/28/1983
4388309Process for suppressing graft rejection in organ transplantation
Suppression of the immunological rejection mechanism of a host which has received an organ transplant in achieved by the daily administration to the host of a ganglioside agent which effectively blocks the soluble immunological cell mediator interleukin 2...
06/14/1983
4309418Anti-tumor agent from human serum and process
The invention relates to an anti-tumor agent prepared from human serum by the process steps of multiple salting out, centrifuging, desalting and gel filtration....
01/05/1982
4127648Ichorin and its uses
This application relates to novel blood serum fractions, Ichorin, Ichorin1 and Ichorin2, capable of transferring cell mediated immunity, and to the methods for the preparation and use thereof....
11/28/1978
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