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| Number | Title | Issue Date |
| 8012932 | Contraceptives based on SP22 and SP22 antibodies Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided. ... | 09/06/2011 |
| 7432067 | Methods of detection of MATER protein autoantibodies Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not pr... | 10/07/2008 |
| 7211255 | Contraceptives based on SP22 and SP22 antibodies Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided. ... | 05/01/2007 |
| 7189812 | Human gene critical to fertility Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygo... | 03/13/2007 |
| 6596310 | Method of artificial insemination by timed release of sperm from capsules or solid beads A method is provided for encapsulating sperm in a particle wherein the particle provides for the timed release of the sperm. In particular, the method uses a gel forming polymer to form the particle and a medium for maintaining most of the sperm in a non-... | 07/22/2003 |
| 6455041 | Immunogenic epitopes of the human zona pellucida protein (ZP1) Immunogenic epitopes of human zona pellucida protein useful in inducing antibodies to zona pellucida protein.... | 09/24/2002 |
| 6399579 | Compositions comprising icariside I and anhydroicaritin and methods for making the same Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genu... | 06/04/2002 |
| 6355235 | Topical application of antibodies for contraception and for prophylaxis against sexually transmitted diseases Certain antibody molecules are so stable and so potent at immobilizing sperm as well as the pathogens for sexually transmitted diseases (STDs) that they make possible new prophylactic contraceptive methods: (a) for men, a skin lotion containing antibodies... | 03/12/2002 |
| 6107102 | Therapeutic microdevices and methods of making and using same A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am range. Also disclosed are microfabrication methods for making s... | 08/22/2000 |
| 6045786 | Topical application of antibodies for prophylaxis against sexually transmitted diseases and pregnancy Certain antibody molecules are so stable and so potent at immobilizing sperm as well as the pathogens for sexually transmitted diseases (STDs) that they make possible new prophylactic contraceptive methods: (a) for men, a skin lotion containing antibodies... | 04/04/2000 |
| 6027727 | Materials and methods for immunocontraception A method for specifically inducing transient infertility or permanent sterility in a host animal by selective vaccination with specific zona pellucida proteins or immunocontraceptively active fragments thereof. Novel zona pellucida DNA sequences encoding ... | 02/22/2000 |
| 5843446 | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines This invention relates to immunogenic luteinizing hormone releasing hormone (LHRH) peptides that lead to suppression of LHRH activity in males or females. These peptides are useful for inducing infertility and for treating prostatic hyperplasia, androgen-... | 12/01/1998 |
| 5753231 | Primate intra-acrosomal sperm antigen for use in a contraceptive vaccine A substantially purified intra-acrosomal primate sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with primate sperm after the acrosome reaction. In particular, it remains associated with the inner and ou... | 05/19/1998 |
| 5721348 | DNA encoding PH-20 proteins The disclosure relates to isolated DNA encoding all or a portion of a surface protein present in sperm of a mammal. This surface protein of sperm is essential for fertilization in the mammal. Preferably, the sperm surface protein is the PH-20 protein.... | 02/24/1998 |
| 5439362 | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM... | 08/08/1995 |
| 5436157 | Human intra-acrosomal sperm antigen A substantially purified intra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer ... | 07/25/1995 |
| 5403586 | LHRH-TraTp fusion proteins This invention relates to the preparation of novel fusion proteins which comprise an analogue of LHRH and TraTp or an analogue of TraTp. The fusion proteins of the invention are useful as components of vaccines for the inhibition or control of reproductiv... | 04/04/1995 |
| 5348866 | Genes encoding porcine zona pellucida protein PZP-4, expression thereof and contraceptive vaccines comprising expressed (poly) peptides This invention relates to a DNA sequence comprising at least part of a porcine zona pellucida PZP-4 or -4ଲ gene coding for an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2, respectively, in SEQUENCE LISTING. This invention a... | 09/20/1994 |
| 5324512 | [Gln']-luteinizing hormone releasing hormone conjugate of tetanus vaccine and its uses The present prevention provides an effective, fast acting method of vaccination useful in suppressing gonadotropic hormone release. The vaccine utilizes LHRH conjugated at its amino terminus to a protein carrier and can be mixed with either adjuvants or d... | 06/28/1994 |
| 5227160 | Monoclonal antibody NUH2 capable of inactivating motility of human sperm, antigen defined by said monoclonal antibody and methods of using said monoclonal antibody and antigen Monoclonal antibody NUH2 produced by a hybridoma having ATCC deposit no. HB 9762. An isolated antigen capable of specifically binding to anti-human sperm antibodies including NUH2 and comprising at least an epitope having a sialyl I structure, and any ana... | 07/13/1993 |
| 5175148 | Sperm antigen corresponding to a sperm autoantigenic epitope and methods of using the same Disclosed is a synthetic peptide, useful as an immunocontraceptive agent and for the diagnosis of autoimmune infertility, which corresponds to an autoantigenic epitope of Rabbit Sperm Membrane Autoantigen (RSA). The synthetic peptide is selected from the ... | 12/29/1992 |
| 5037805 | Methods of contraception Methods are disclosed for regulating ovulation or fertility in female mammals, for regulating spermatogenesis in males and for treating conditions such as endometriosis. Administration of effective amounts of an FSH-Inhibiting Protein (FSH-IP) can be used... | 08/06/1991 |
| 5036047 | Method and composition for preventing conception A method for preventing conception in mammals which includes administering to the mammals a composition containing (1) free LHRH or its analog and (2) an immunogenic conjugate between LHRH or its analog and a carrier protein. Free LHRH or its analog acts ... | 07/30/1991 |
| 5021244 | Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM... | 06/04/1991 |
| 5006334 | Antigenic modification of polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 04/09/1991 |
| 4996297 | Recombinantly expressed rabbit zona pellucida polypeptides The invention relates to antigenic preparations useful for inducing the production of antibodies in an individual which will bind to epitopes on zona pellucida. Also disclosed are immunogenic compositions and methods for immunizing an individual to enable... | 02/26/1991 |
| 4975420 | Agents and procedures for provoking an immune response to GnRH and immuno sterilizing mammals A technique has been developed to cause a mammal to generate antibodies which will bind to its native GnRH thus suppressing the mammal's fertility. The technique involves vaccinating a mammal with a novel conjugate of an immuno stimulating carrier and a n... | 12/04/1990 |
| 4966888 | hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine Purified hCG-hLH receptor, hCG-hLH receptor-hCG complex and combinations between their subunits as antigens, as well as antibodies thereto which are useful as a contraceptive vaccine.... | 10/30/1990 |
| 4912201 | Monoclonal antibodies and antisera to intragonadal regulatory protein A protein having a molecular weight of from about 10,000 to 18,000 daltons, isoelectric points of from about pH 4.0 to 6.5 and having the reversible biological effect of inhibiting aromatase activity in a biological system, and antibodies to the protein, ... | 03/27/1990 |
| 4879112 | Monoclonal antibodies agaisnt GnRH A monoclonal antibody against GnRH and particularly designated USASK/DSIL-GnRH is produced by a hybrid formed by fusion of cells from a myeloma line and antibody producing cells of the immune system from an animal previously immunized with a source of GnR... | 11/07/1989 |
| 4801689 | Physilogically active glycoprotein and process for production thereof A new glycoprotein ZP-0 originating from the oviduct of a mammal having a molecular weight of about 200,000 to 240,000, as determined by SDS-polyacrylamide gel density-gradient electrophoresis having an isoelectric point of about 4 to 6.2, as determined b... | 01/31/1989 |
| 4795634 | Method for contraception by immunization against the zona pellucida This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies... | 01/03/1989 |
| 4780312 | Birth control vaccine A polyvalent vaccine for control of fertility is disclosed, the vaccine having a multiplicity of determinant antigens in the reproductive system of mammals, the antigens being linked to at least one carrier. The precise manner of linkage can differ, and p... | 10/25/1988 |
| 4753794 | Use of mullerian inhibiting substance as a contraceptive agent The invention discloses a novel use of Mullerian Inhibiting Substances (MIS) as a contraceptive agent. MIS has been found to inhibit the maturation of oocytes in vitro. Additionally, the invention provides a means for restoring the fertility of females wh... | 06/28/1988 |
| 4732763 | Active/passive immunization of the internal female reproductive organs Antibody or antigen containing microparticles for the active or passive immunization of the internal female reproductive organs, comprising: microparticles of an antigen or antibody incorporated in a matrix material which is biocompatible and biologically... | 03/22/1988 |
| 4676981 | Monoclonal antibodies against GnRH A monoclonal antibody against GnRH and particularly designated USASK/DSIL-GnRH is produced by a hybrid formed by fusion of cells from a myeloma line and antibody producing cells of the immune system from an animal previously immunized with a source of GnR... | 06/30/1987 |
| 4608251 | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues A conjugate between a nona- or decapeptide of the formula (i) or (ii): or or mixtures of peptides (i) and (ii). and a protein is provided which, when used per se or when mixed with a suitable adjuvant, yields a vaccine which acts as an immunogen for LHRH and i... | 08/26/1986 |
| 4457914 | Fecundity of domestic livestock A method for increasing the fecundity of a flock of female sheep or goats comprising immunizing the animals in the flock against a steroidal androgen, such as 4-androstene-3, 17-dione or testosterone, or a steroidal oestrogen, such as oestrone, as by admi... | 07/03/1984 |
| 4448767 | Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex A method of manufacturing and a raw material and its useage are disclosed for increasing the percentage of mammalian offspring of either sex. The process of use utilizes a male-specific antibody coupled to a solid-phase immunoabsorbent material to effect ... | 05/15/1984 |
| 4384995 | Antigenic modification of polypeptides Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various ki... | 05/24/1983 |
