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| Number | Title | Issue Date |
| 8182801 | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention p... | 05/22/2012 |
| 8173115 | Particle compositions with a pre-selected cell internalization mode A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the... | 05/08/2012 |
| 8153110 | Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic a... | 04/10/2012 |
| 8105570 | Methods and compositions for controlled release of drugs This invention provides a method and compositions for the controlled release of drugs that have been attached by means of a covalent bond to a polymer or other moiety that blocks activity of the drug until it has been released. A two-stage process is provided in whi... | 01/31/2012 |
| 8012463 | Coordination complex of diaminocyclohexaneplatinum(II) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same A coordinate complex of diaminocyclohexane platinum (II) with a block copolymer comprising a poly(ethylene glycol) segment and a poly(carboxylic acid) segment is provided. The complex can be effectively used in treatments for tumors, in particular malignant tumors. | 09/06/2011 |
| 7955594 | Polymers with structure-defined functions An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a resid... | 06/07/2011 |
| 7919076 | PH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of α-amino acids, ε-ami... | 04/05/2011 |
| 7862807 | Dendrimers as molecular translocators Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, ... | 01/04/2011 |
| 7829074 | Hydroxypatite-targeting poly(ethylene glycol) and related polymers Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two te... | 11/09/2010 |
| 7811556 | Polymeric modifiers and pharmaceutical compositions A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 a... | 10/12/2010 |
| 7794699 | Nano-structured blood substitutes An improved synthetic blood substitute which exhibits excellent long-term storage stability at both high and low temperatures is suitable for use in various biomedical and biotechnical applications, including resuscitation of trauma victims that have suffered massiv... | 09/14/2010 |
| 7780957 | Polyethylene glycol/polycation block copolymers The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynuc... | 08/24/2010 |
| 7767197 | Delivery vehicle composition and methods for delivering antigens and other drugs The present invention provides an immunogen composition and methods for using the same for the development of immunity, and particularly at mucosal sites in a mammal, thereby providing immunity at the site of entry for many major pathogenic organisms and also system... | 08/03/2010 |
| 7754200 | Phosphate transport inhibitors Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): R1 and R2 are independently —H, an electron withdrawing group or a C1-C10 alkyl ... | 07/13/2010 |
| 7744861 | Multi-arm polymer prodrugs Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide ... | 06/29/2010 |
| 7736635 | Branched molecular scaffolds for linking polymer residues to biologically active moieties Branched molecular scaffolds are provided which are capable of linking two polymer residues (derived, for example, from polyethylene glycol) to two, three or four residues derived from biologically active molecules (e.g. from whole antibodies or from functionally ac... | 06/15/2010 |
| 7569214 | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention p... | 08/04/2009 |
| 7560100 | Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wher... | 07/14/2009 |
| 7432330 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7432331 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7396527 | Antibiotic polymers Polymers (i.e. polyesters, polyamides, polythioesters, polyanhydrides, or a mixture thereof) which degrade hydrolytically to provide a combination of a beta-lactam antibiotic (e.g., amoxicillin) and a beta-lactamase inhibitor (e.g., clavulanic acid) (or a pharmaceut... | 07/08/2008 |
| 7384626 | Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents The present invention describes compositions and methods for sorbing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendr... | 06/10/2008 |
| 7354596 | Anti-microbial agent delivery system A delivery system for delivering an anti-microbial agent to a surface in a time release manner. The delivery system includes one or more polymeric particles (e.g., microspheres, core/shell particles, latexes, porogens, cryogenically ground beads, condensation polyme... | 04/08/2008 |
| 7347850 | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.... | 03/25/2008 |
| 7348182 | Directed microwave chemistry The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increas... | 03/25/2008 |
| 7345117 | Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have anticoagulative, non-thrombogenic, antiviral and anti-inflammatory properties. Th... | 03/18/2008 |
| 7342122 | Bisphosphonate complexes Bisphosphonate compounds are disclosed, particularly bisphosonate conjugates useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis. ... | 03/11/2008 |
| 7339038 | Heparanase specific molecular probes and their use in research and medical applications A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level ... | 03/04/2008 |
| 7326426 | Compositions and medical devices utilizing bioabsorbable liquid polymers The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid pol... | 02/05/2008 |
| 7316811 | Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide se... | 01/08/2008 |
| 7311892 | Multidrug multiligand conjugates for targeted drug delivery Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a ... | 12/25/2007 |
| 7311901 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also r... | 12/25/2007 |
| 7300457 | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of... | 11/27/2007 |
| 7291312 | Ozone removing material and method for preparing the same An object of the present invention is to solve problems of conventional ozone-scavenging materials and to provide an ozone-scavenging material capable of effectively decomposing/removing ozone at low cost. To attain the above object, the present invention provides a... | 11/06/2007 |
| 7288264 | Contact-killing antimicrobial devices Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocida... | 10/30/2007 |
| 7287650 | Structures that inhibit microbial growth Structures treated with a microbiological interception enhancing agent comprising of a water-soluble cationic material having a counter ion associated therewith at specific sites on the cationic material, in combination with a biologically active metal salt, wherein... | 10/30/2007 |
| 7285287 | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses Methods of producing biocompatible intraluminal prostheses are provided and include immersing polymeric material of an intraluminal prosthesis in a densified carbon dioxide composition under controlled conditions such that toxic materials are absorbed by the densifi... | 10/23/2007 |
| 7285285 | Photoactivatable diazirine-active agent compounds, compositions comprising them and uses thereof Disclosed herein are a cosmetic composition comprising at least one diazirine active-agent compound comprising a diazirine covalently bonded to a cosmetic active agent, said at least one diazirine-active agent compound and the uses of the composition or of the compo... | 10/23/2007 |
| 7265097 | Methods of drug delivery using sulphated chitinous polymers The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes... | 09/04/2007 |
| 7264739 | Dendrimer fluid purification method A dendrimer complex comprising a dendrimer and an antimicrobial agent with the dendrimer complex placeable directly into a fluid to inhibit growth of microbes or rid the fluid of microbes. In a further embodiment of the invention the dendrimer complex is secured to ... | 09/04/2007 |
