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| Number | Title | Issue Date |
| 8173113 | Bioadhesive composition and patch A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also descri... | 05/08/2012 |
| 8088365 | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation... | 01/03/2012 |
| 8048407 | In situ gelling self-reactive materials for embolization A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component... | 11/01/2011 |
| 8029774 | Wound healing polymeric networks A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization af... | 10/04/2011 |
| 7988956 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels... | 08/02/2011 |
| 7887789 | Polymer derivatives having particular atom arrangements Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent ... | 02/15/2011 |
| 7858077 | Functionalized phenolic esters and amides and polymers therefrom The present invention relates to a compound of the formula: R-AR—O—Y—R′ Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO2, —NH | 12/28/2010 |
| 7794697 | Enhancement of lens regeneration using materials comprising polysiloxane polymers The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. Enhancement of lens regeneration is accomplished by the administration of a composition comprising a polysiloxane polymer having functional acryl groups usefu... | 09/14/2010 |
| 7794696 | Biodegradable polyacetals for in vivo polynucleotide delivery Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications. ... | 09/14/2010 |
| 7754199 | Pharmaceutical compositions comprising crosslinked amine polymer with repeat units derived from polymerization of tertiary amines The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical com... | 07/13/2010 |
| 7700086 | Internal clamp for surgical procedures One aspect of the present invention relates to a method of occluding a vascular site in a mammal, comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse... | 04/20/2010 |
| 7691364 | Functionalized drugs and polymers derived therefrom Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO-(glycolic acid moiety), —CH(CH3)COO-(lacti... | 04/06/2010 |
| 7678369 | Anionic polymers as toxin binders and antibacterial agents The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the poly... | 03/16/2010 |
| 7655221 | Methods of treating disease with random copolymers The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of aut... | 02/02/2010 |
| 7651682 | Polymerizable emulsions for tissue engineering Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or d... | 01/26/2010 |
| 7651683 | Polymerizable emulsions for tissue engineering Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or d... | 01/26/2010 |
| 7651681 | Method and compositions for in situ formation of protective and/or medicated films on body tissue Methods and compositions for forming protective and/or medicated films on body tissue. Liquid compositions contain a hydrophobically modified polymer, other than an esterified lower-hydroxyalkyl-substituted cellulose, suspended or dissolved in a solvent. The modifie... | 01/26/2010 |
| 7608253 | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels... | 10/27/2009 |
| 7575740 | Compositions for tissue augmentation Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor componen... | 08/18/2009 |
| 7537754 | Polymerizable emulsions for tissue engineering Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or d... | 05/26/2009 |
| 7504095 | Method for obtaining precursor Z and use thereof for the production of a means for therapy of human molybdenum cofactor deficiency The invention relates to a method for obtaining the molybdopterin derivative precursor Z, wherein an over-production of precursor Z occurs in host organisms by recombinant expression of precursor Z synthesizing proteins. The invention further relates to the use of p... | 03/17/2009 |
| 7491383 | Compositions having enhanced pharmacokinetic characteristics Compositions comprising a therapeutic component and an efficacy enhancing component, that enhances the pharmacokinetic disposition of the therapeutic component, are disclosed. The therapeutic component may include an alpha-2-adrenergic agonist and the efficacy enhan... | 02/17/2009 |
| 7473417 | Inherently radiopaque bioresorbable polymers for multiple uses Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresor... | 01/06/2009 |
| 7435380 | Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from... | 10/14/2008 |
| 7427316 | Tropolone complexes as wood preservatives Complexes of tropolone and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the complexes were stably retained in the wood providing a long lasting preserva... | 09/23/2008 |
| 7427407 | Cosmetics Cosmetics containing the following components (A) and (B): (A) an oil-absorbing powder having a squalane-absorbing ability of 1 ml/g or more; and (B) a compound having an affinity for component (A) lower than that of sebum, and having an ability to absorb the sebum ... | 09/23/2008 |
| 7419504 | Poly(ester amide) block copolymers Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can ob... | 09/02/2008 |
| 7420029 | Tissue-specific transporter inhibitor The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a t... | 09/02/2008 |
| 7393520 | Decorative cosmetic and dermatological products The invention provides decorative cosmetic and dermatological compositions comprising at least one copolymer obtained by free-radical copolymerization of A) acryloyld imethyltaurine and/or acryloyld imethyltaurates, B) optionally, one or mo... | 07/01/2008 |
| 7378449 | Poly(bromoaryl)alkane additives and methods for their preparation and use An additive mixture useful as a flame retardant is described. The mixture is comprised of (i) a poly(bromophenyl)alkane having in the molecule in the range of 13 to 60 carbon atoms and in the range of two to four aryl groups and (ii) a poly(bromophenyl)bromoalkane h... | 05/27/2008 |
| 7368169 | Hydrazide compounds with angiogenic activity Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(═O)—R2—P—R1 (I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, l... | 05/06/2008 |
| 7364585 | Medical devices comprising drug-loaded capsules for localized drug delivery A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer polyelectrolyte shell. The medical device is adapted to apply a press... | 04/29/2008 |
| 7364756 | Anti-virus hydrophilic polymeric material The invention provides a method for imparting antiviral properties to a hydrophilic polymeric material comprising preparing a hydrophilic polymeric slurry, dispersing an ionic copper powder mixture containing cuprous oxide and cupric oxide in said slurry and then ex... | 04/29/2008 |
| 7358215 | Quaternary ammonium salts as thickening agents for aqueous systems This invention relates to the use of alkyl amido quaternary ammonium salts, and formulations thereof, as thickening agents in aqueous based fluids, especially those used in oil field applications. The quaternary ammonium salts of the present invention exhibit improv... | 04/15/2008 |
| 7341741 | Pharmaceutical composition for the treatment of inflammatory bowel disease A polysaccharide selected from xanthan gum and HPMC is used for the treatment or prophylaxis of IBD, especially Crohn's Disease, left-sided ulcerative colitis or pouchitis. ... | 03/11/2008 |
| 7335181 | Nitric oxide decontamination of the upper respiratory tract A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. A... | 02/26/2008 |
| 7323163 | Film-forming compositions and methods Film-forming compositions, as well as methods of making and using, wherein the compositions include an optional active agent, water, a surfactant, and a water-soluble or water-dispersible vinyl polymer comprising amine group-containing side-chains and a copolymerize... | 01/29/2008 |
| 7323194 | Hydrophilic antimicrobial composition for an air conditioner evaporator of a vehicle The present invention relates to a hydrophilic antimicrobial coating composition for an air conditioner evaporator of a vehicle with improved durability. In one embodiment of the present invention, the antimicrobial composition comprises a hydrophilic organic polyme... | 01/29/2008 |
| 7316811 | Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide se... | 01/08/2008 |
| 7317059 | Ligand immobilization support A polymer comprising a styrene-based monomer and t-butyl methacrylate, wherein a proportion of the styrene-based monomer in the polymer is 30% by mol to 90% by mol and the polymer has a functional group represented by the following formula (1) which includes a malei... | 01/08/2008 |
