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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8110227 | Dairy based foodstuff containing central nervous system lipids The central nervous system (CNS), i.e. the spinal cord and the brain, contains a large amount of various lipids, collectively called CNS lipids. These lipids are essential for embryonic induction but are also active in the adult body in keeping our cells in healthy ... | 02/07/2012 |
| 7339853 | Time stamping events for fractions of a clock cycle Generally, the embodiments are directed to circuits and methods for time stamping an event at a fraction of a clock cycle. A time stamping circuit comprises two or more detection circuits. The detection circuits receive an event-in signal and generate event signals ... | 03/04/2008 |
| 7189418 | Method for extracting lipid mixture containing phospholipids comprising polyunsaturated fatty acids from viscera of fish, method for preserving viscera prior to extraction, and lipid mixture extracted thereby The present invention provides a method for extracting a lipid mixture having a high percentage of phospholipids comprising polyunsaturated fatty acids. The method comprises the steps of (a) heating the viscera of fish with hot water or steam; and (b) extracting fro... | 03/13/2007 |
| 7144588 | Method of preventing surgical adhesions The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and ... | 12/05/2006 |
| 7086473 | Submersible pumping system with sealing device A submersible pumping system includes a pump assembly that is connected to a motor assembly. The pump assembly includes a pump intake having an intake hole, a pump housing connected to the pump intake and a pump discharge head connected to the pump housing. An intak... | 08/08/2006 |
| 7041506 | Peptides promoting cell adherence, growth and secretion The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in large quantity by such means as chemical synthesis or recombinant DNA ... | 05/09/2006 |
| 7041458 | Methods and reagents for determining protein S The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of the complex formed in the samp... | 05/09/2006 |
| 6881546 | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor Methods and compositions are disclosed that are useful for the prevention and/or treatment of cardiovascular and cardiac diseases and disorders, or damage resulting from surgical or medical procedures that may cause ischemic or ischemic/reperfusion damage in humans;... | 04/19/2005 |
| 6844011 | Methods for inhibiting rejection of transplanted tissue A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response... | 01/18/2005 |
| 6835715 | Mammalian dihydroouabain-like factor and therapeutic compositions A novel mammalian dihydroouabain-like factor is disclosed which substantially fails to cross-react with mammalian ouabain-like factor (OLF) for binding to anti-OLF antibody, but cross-reacts with plant-related dihydroouabain (dho) for binding to anti-dho antibody, h... | 12/28/2004 |
| 6649160 | Sertoli cells as transplantation facilitator for cell transplantation A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.... | 11/18/2003 |
| 6613572 | Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property The present invention relates to an agent for the expression of long-term potentiation of synaptic transmission, which contains a compound having a brain somatostatin activation property as an active ingredient and to a screening method of an agent for th... | 09/02/2003 |
| 6610538 | Reconstructed laminae of human epithelium corneae and method of producing the same A method of reconstructing laminae of human epithelium corneae in vitro to be used in grafts from cultures of limbar stem cells as well as a method of selecting and transferring such cells to fibrin substrate.... | 08/26/2003 |
| 6500809 | Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith Neural tissue edema is treated by circulating a hyperoncotic artificial cerebrospinal fluid in the cerebrospinal fluid pathway in the vicinity of edematous tissue to cause the edematous tissue to be dehydrated due to an oncotic gradient between the hypert... | 12/31/2002 |
| 6428950 | Assay to identify compounds that alter apolipoprotein E expression The present invention provides a method of assaying for and arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing ଲ-amyloid plaque burden by the administration of compounds that r... | 08/06/2002 |
| 6423347 | Method and product using sturgeon notochord for alleviating the symptoms of arthritis This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more particularly rheumatoid arthritis in humans through the ente... | 07/23/2002 |
| 6376460 | Method of modulating cellular activity The present invention is directed to compositions and methods for modulating cellular activity. The invention is particularly suited for delivering an agent which modulates cellular activity to a neuronal cell. In a typical embodiment, a composition of th... | 04/23/2002 |
| 6376238 | Culture media for neurons, methods for preparing the culture media, and methods for culturing neurons The present invention is directed to a culture medium for neurons prepared by adding albumin to a culture supernatant obtained from a culture of primary astroglial cells in a trophic medium supplemented with insulin and transferrin. The culture medium of ... | 04/23/2002 |
| 6352723 | Brain-derived alkali-soluble immunoregulatory composition The current invention relates to an active factor present in homogenized brain tissue which inhibits antigen-driven proliferation of lymphocytes in culture, but stimulates proliferation in response to most mitogens. The inhibitory activity can be destroye... | 03/05/2002 |
| 6350473 | Method for treating hypercholesterolemia, hyperlipidemia, and atherosclerosis A method for reducing mammalian serum total cholesterol, LDL cholesterol, apolipoprotein B and triglyceride levels, by ingesting a stabilized rice bran derivative selected from the group consisting of an enzyme treated stabilized rice bran, an insolubiliz... | 02/26/2002 |
| 6348042 | Bioactive shunt The present invention relates to a shunt, and a method for treating catheters, more particularly shunts, wherein the catheter is made of a biocompatible material and adapted at least for insertion into the brain of a living organism and enzymes are impreg... | 02/19/2002 |
| 6344358 | Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property The present invention relates to an agent for the expression of long-term potentiation of synaptic transmission, which contains a compound having a brain somatostatin activation property as an active ingredient and to a screening method of an agent for th... | 02/05/2002 |
| 6313268 | Secretases related to Alzheimer's dementia This invention is directed to a novel ଲ-secretase that produces the Aଲ peptide found in Alzheimer's Disease. One ଲ-secretase is a protein having a molecular weight of about 61, 81 or 88 kDa that cleaves an amyloid precursor protein (APP)... | 11/06/2001 |
| 6310040 | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at least one of the following substances: IGF-I; a functional... | 10/30/2001 |
| 6267955 | Mononuclear phagocytes and their use to promote axonal regeneration Methods and compositions are disclosed for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory t... | 07/31/2001 |
| 6239111 | In vivo method of improving survival rate of brain neurons The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl gro... | 05/29/2001 |
| 6231879 | Biocompatible devices with foam scaffolds This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible material that is loaded with a core made of a reticulate f... | 05/15/2001 |
| 6179826 | Implantable therapy systems and methods Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves s... | 01/30/2001 |
| 6167888 | Method for inducing partial recovery of lost voluntary motor function after spinal cord injury in a mammal The invention provides means for inducing partial recovery of motor function lost in a mammal as a consequence of an injury to its spinal cord which includes a lesion of the cerebrospinal projections (CST) of the cord. Axonal growth is initiated in the CS... | 01/02/2001 |
| 6149946 | Method and product using sturgeon notochord for alleviating the symptoms of arthritis This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more particularly rheumatoid arthritis in humans through the ente... | 11/21/2000 |
| 6132977 | Measurement of a CNS protein in cerebrospinal or amniotic fluid SNAP-25 (synaptosomal associated protein) is purified from cerebrospinal or amniotic fluid for immunoassay and quantitation. Quantitation of these proteins is useful in the diagnosis and monitoring of brain disorders and diseases such as schizophrenia and... | 10/17/2000 |
| 6096716 | Liposome-mediated transfection of central nervous system cells Disclosed are methods for use in transferring nucleic acids into central nervous system cells in vivo and in vitro and/or for stimulating central nervous system cells. Neurotrophic genes are shown to stimulate neurofilament cells and to promote nerve cell... | 08/01/2000 |
| 6054142 | Biocompatible devices with foam scaffolds A biocompatible cell device having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule.... | 04/25/2000 |
| 5998370 | Agents for the prevention and/or treatment of radiation-induced disorders by administrating TCF-II The use of Tumor Cytotoxic Factor-II (TCF-II) enables the prevention and/or treatment of radiation-induced disorders.... | 12/07/1999 |
| 5985334 | Screening methods to identify anti-convulsant compounds A method for identifying anti-convulsant compounds is presented. The binding of test compounds with a receptor obtained from rat forebrain is determined. The receptor has a Kd of about 40 nM and a molecular weight of about 130 kD. Two pyran compounds that... | 11/16/1999 |
| 5925802 | Functional reconstitution of SCID-bo mice with bovine fetal hematopoietic tissues The present invention provides a non-human chimeric mammal, comprising a severe-combined immunodeficient mammal engrafted with bovine immune system tissues, wherein said chimeric mammal is functionally reconstituted. Also provided is a method of producing... | 07/20/1999 |
| 5922359 | Skin treatment compositions comprising unoxidized nerve tissue Topical composition and method for retexturizing skin by peeling the outer layer of dead skin cells, sebum and other impurities, the composition containing unoxidized nerve tissue and a slightly abrasive powdery component in a cosmetically acceptable carr... | 07/13/1999 |
| 5876954 | Cytotoxic factor as is associated with multiple sclerosis, its detection and its quantification Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and... | 03/02/1999 |
| 5856158 | Purified nitric oxide synthase from rat brain A nitric oxide synthase (NOS) protein is obtained from rat brain and purified to a specific activity at least 6,360-fold that of a crude tissue preparation. The NOS protein has a denatured MW of 105 kD determined by SDS-PAGE, a dimeric MW of 230 kD determ... | 01/05/1999 |
| 5853747 | Therapeutic and dietetic uses of a brain phospholipid-based complex The therapeutic or dietetic use of a preparation based on phospholipids extracted from pig brains for treating aging disorders consisting of memory disorders, attention disorders, intellectual efficacy disorders, humor and affectivity disorders, and think... | 12/29/1998 |
