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| Number | Title | Issue Date |
| 7498047 | Methods for treatment of thiol-containing compound deficient conditions Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodi... | 03/03/2009 |
| 7432308 | Therapeutic compositions for the treatment of a respiratory tract disease The equilibrium between G actin and F actin is shifted towards the F actin confirmation with compounds such as the ionic form of magnesium or potassium. The higher amount of F actin decreases the inhibition of nucleases such as DNAse I by monomeric G actin. The incr... | 10/07/2008 |
| 7273847 | Peptides with antioxidant and antimicrobial properties Methods of treating conditions associated with lipid oxidation or microbial proliferation include the step of administering a composition comprising a pharmacologically effective amount of an antioxidant or antimicrobial lung surfactant protein compound. Peptides de... | 09/25/2007 |
| 7247317 | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant | 07/24/2007 |
| RE39337 | Nude mouse model for human neoplastic disease A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained. ... | 10/10/2006 |
| 7053176 | Combination of C1-INH and lung surfactant for the treatment of respiratory disorders Pharmaceutical composition for the treatment of infant respiratory distress syndrome and acute lung injury (including adult respiratory distress syndrome) which contains C1 esterase inhibitor (C1-INH) and lung surfactant which comprises a lung surfactant protein. | 05/30/2006 |
| 6998410 | Compositions Novel compositions for the treatment of IRDS and ARDS are indicated which contain N-(3,5-dichloro-pyrid-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxybenzamide and/or its pharmacologically tolerable salts and lung surfactant. ... | 02/14/2006 |
| 6982161 | Process for the utilization of ruminant animal methane emissions A process for the utilization of the methane contained within ruminant animal exhalation, specifically to a process that utilizes the methane contained within ruminant animal exhalation as a source of carbon and/or energy for the production of methane-utilizing micr... | 01/03/2006 |
| 6858223 | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) A composition comprising a combination of a compound of formula I in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt thereof, and lung surfactant is useful for treating patien... | 02/22/2005 |
| 6838428 | Surfactant protein D for the prevention and diagnosis of pulmonary emphysema Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used t... | 01/04/2005 |
| 6770619 | Lung surfactant compositions with dynamic swelling behavior Lung surfactant compositions are provided which can form a swelling phase when dispersed in a medium containing electrolytes. Hereby, a more active spreading of the lung surfactant into the alveoli can be obtained after administration to the lungs. Further provided ... | 08/03/2004 |
| 6569436 | Method of using a vaccine This invention is directed to methods of preventing or reducing the severity of asthma or the risk of development of same in an individual. The method relies on administration to the airways of the individual of an immunologically effective dose of a myco... | 05/27/2003 |
| 6255354 | Preparation of a pulmonary surfactant for instillation and oral application A pulmonary surfactant formulation for instillation and oral application, containing at least 0.1% by weight of 2,3 -dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone in addition to an effective amount of pulmonary surfactant and usual excipients.... | 07/03/2001 |
| 6231879 | Biocompatible devices with foam scaffolds This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible material that is loaded with a core made of a reticulate f... | 05/15/2001 |
| 6228891 | Use of 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone 2,3-Dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone can be used for the topical and oral treatment of diseases of the skin and the mucosae of the mouth, the stomach, the bowels, the vagina and the lung.... | 05/08/2001 |
| 6180142 | Reduction of surfactant inactivation in pulmonary surfactant therapy Nonionic hydrophilic polymers or carbohydrates are administered either individually or in conjunction with therapeutically active pulmonary surfactants for the treatment of a variety of lung ailments. Included among the activities of these agents is their... | 01/30/2001 |
| 6129934 | Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction The present invention relates to the method of using a composition of matter that maintains the biophysical and physiological characteristics of natural surfactant, including the rapid and spontaneous adsorption of dilute suspensions to an air-liquid inte... | 10/10/2000 |
| 6054142 | Biocompatible devices with foam scaffolds A biocompatible cell device having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule.... | 04/25/2000 |
| 5952303 | Lyophilized pulmonary surfactant peptide compositions An improved solid pharmaceutical composition comprising a lyophilized liposomal KL4 pulmonary surfactant composition comprising: (a) about 1 to about 10 percent weight KL4 polypeptide; and (b) 50 to about 100 weight percent phospholipid comprised of about 3 parts ... | 09/14/1999 |
| 5902567 | Method of detecting lung disease A method of faciltating the obtaining of a mucus sample from at least one lung of a subject comprises administering a physiologically acceptable salt to at least one lung of the subject in an amount effective to hydrate lung mucus secretions therein, and ... | 05/11/1999 |
| 5708144 | Process for the purification of natural pulmonary surfactant material using supercritical fluids A process for purifying natural pulmonary surfactant by dispersing animal lung tissue on an inert carrier and extracting with a supercritical fluid.... | 01/13/1998 |
| 5667766 | Non-human animal model of a human airway, methods of use A non-human animal characterized by a human airway, the human airway being open-ended. The human airway is characterized by cells derived from the human respiratory system. The non-human animal and the human airway it carries are useful as models of human... | 09/16/1997 |
| 5569812 | Nude mouse model for human neoplastic disease A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.... | 10/29/1996 |
| 5560935 | Physiologically active substances extracted from activated tissues The present invention provides a physiologically active substance which inhibits plasma kallikrein production, improves peripheral blood flow, and exhibits analgesic, antiinflammatory and antiallergic action. The physiologically active substance of the pr... | 10/01/1996 |
| 5552161 | Low viscosity, highly concentrated surfactant suspension Low viscosity, highly concentrated surfactant suspensions for replacement therapy In diseases of the respiratory tract are described. The suspensions are characterised in that they contain calcium and/or magnesium ions bound to the surfactant and unbound ... | 09/03/1996 |
| 5491284 | Nude mouse model for neoplastic disease A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.... | 02/13/1996 |
| 5198216 | Performance enhancing compositions of matter, and methods of preparing and utilizing same A composition for enhancing the performance of animals, such as horses or dogs, is composed of adrenal and pituitary raw tissue concentrates, vitamin C, bioflavonoid complex, pantothenic acid, methionine, choline, vitamin B1, vitamin B2, vitamin B6, niaci... | 03/30/1993 |
| 5057324 | Kallikrein inhibitor substance, a process for preparation and pharmaceutical compositions thereof A physiologically active substance is extracted from infected tissues inoculated with a poxvirus. The novel substance of the present invention has inhibitory action against the formation of kallikrein, thus is useful as drugs such as antiinflammatory, ana... | 10/15/1991 |
| 5024995 | Natural pulmonary surfactant, method of preparation and pharamceutical compositions A pulmonary surfactant of animal origin made up of a high percentage of phospholipids (.perspectiveto.99%), by a protein fraction and characterized by the absence of carbohydrates and cholesterol. The surfactant of the invention, obtained through filtration, ... | 06/18/1991 |
| 4985254 | Method of treating ischemic diseases The present invention relates to physiologically active substances extracted from infected tissues inoculated with a poxvirus. The substances of the present invention have excellent actions to improve blood flow and recover functions of diseased tissues, ... | 01/15/1991 |
| 4963358 | Agent for inhibiting proliferation of human malignant tumor cells An agent for inhibiting proliferation of human malignant tumor cells is obtained by culturing the human malignant tumor cells in a medium and removing the malignant tumor cells from the cultured medium.... | 10/16/1990 |
| 4908206 | Extracts of embryonic organs, process for their preparation and pharmaceutical preparation containing them From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulga... | 03/13/1990 |
| 4749522 | Supercritical fluid extraction of animal derived materials Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source material, one may obtain lipids, proteins, nucleotides, sacc... | 06/07/1988 |
| 4571334 | Composition for curing respiratory diseases A composition for curing respiratory diseases which contains a medicine such as antibiotic, chemotherapeutic and anticancer drug for respiratory disease and lung surfactant.... | 02/18/1986 |
| 4544552 | Process for the preparation of cell and tissue regenerating substances Glycolipids having cell- and tissue-regenerating properties are isolated from the blood or organ homogenates of mammals by subjecting the starting material to autolysis and dialysis against an alcoholic-aqueous medium. The glycolipids can be isolated, and... | 10/01/1985 |
| 4402872 | Protein and process for isolating it What are disclosed are an isolated tissue protein, denominated PP16, which can be used to prepare anti-sera useful as diagnostic agents, said protein being found in extracts of some human organs such as the placenta, spleen, stomach, and lung and being ca... | 09/06/1983 |
| 4397839 | Surface active material and process for preparing same A surface active material having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. This material comprises, based on the dry weight of the material, 68.6-90.7% of phospholipid, 0.3-13.0% of neutral fat, 0.0-8.0% ... | 08/09/1983 |
| 4338301 | Lung tissue extract useful for treating hyaline-membrane disease and method for producing the extract A surface active material may be produced from the lung tissue of mammal by means of employing an acetone-treatment procedure as well as an organic solvents mixture-treatment procedure other than the conventional procedures of differential centrifugation,... | 07/06/1982 |
| 4190573 | Process for the isolation of the polyvalent proteinase inhibitor What is disclosed is a method for the isolation of the polyvalent proteinase inhibitor from aqueous extracts of animal organs by adsorbing the inhibitor from its aqueous solutions at pH 0.5 to 10.5 on an ion exchanger containing functional sulfonate or ph... | 02/26/1980 |
| 4083961 | Plasminogen activator pharmaceutical compositions The present invention relates to a pharmaceutical composition comprising a plasminogen activator and a polysaccharide sulphate. The invention also covers a process for preparing the pharmaceutical composition and a process for preparing the plasminogen ac... | 04/11/1978 |
