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| Number | Title | Issue Date |
| 8021692 | Graft materials containing bioactive substances, and methods for their manufacture Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibrob-last Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is con... | 09/20/2011 |
| 7335382 | Compositions and methods for the treatment and prevention of cancer The present invention relates to new classes of anti-cancer agents. In particular, the present invention provides materials derived from natural sources as anti-cancer agents, alone, or in combination with other anti-cancer agents or therapies. ... | 02/26/2008 |
| 7157221 | Processes for making protein hydrolysates from animal peptone and for preserving mucosa A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventi... | 01/02/2007 |
| 7078163 | Process for reducing mineralization of tissue used in transplantation A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device. ... | 07/18/2006 |
| 7045149 | Ruminal fluid inoculation of calves A method to improve the health and growth of suckling dairy calves on dairy farms includes supplementing calves' diets with a ruminal fluid preparation obtained from the rumen of a cow. This supplement provides the calves with the protection needed to develop faster... | 05/16/2006 |
| 6962801 | Protein for blocking platelet adhesion A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12... | 11/08/2005 |
| 6790833 | Antifungal and antibacterial agents The present invention discloses peptides obtained from the MUCD1 domain of the saliva mucin glycoprotein MUC7. The peptides are between 8 and 20 amino acids in length and have a net positive charge. The peptides are obtained from the C-terminus of the MUC7D1 protein... | 09/14/2004 |
| 6726935 | Pharmaceutical composition for preventing and treating erectile impotence using purified sumsoo extract A pharmaceutical composition for prevention or treatment of premature ejaculation and/or hypersensitivity of sexual stimulation is provided, which contains a therapeutically effective amount of a purified essence of Bufonis venenum for prevention or treatment of dys... | 04/27/2004 |
| 6592906 | Anticariogenic dairy product and its use The invention relates to a food composition containing an effective quantity of rennetted milk for preventing or treating dental caries or dental plaque. The invention also relates to a method of preparing the composition.... | 07/15/2003 |
| 6482443 | Antler herb medicine fermented with chicken gizzard and a method for preparation thereof Disclosed are an antler herb medicine and a preparing method thereof. The antler herb medicine is prepared by fermenting a mixture of antler and gizzard membrane at 20-60° C. In the mixture, the weight ratio of antler to gizzard membrane is within the ra... | 11/19/2002 |
| 6444229 | Submucosa gel compositions A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable... | 09/03/2002 |
| 6419911 | Psyllium containing snack bars, processes for making these, and uses thereof The invention is a psyllium containing snack bar. Also included as part of the invention are processes for making snack bars. The product may be used in a therapeutic or dietary regime, for purposes such as increasing dietary fiber or for reducing cholest... | 07/16/2002 |
| 6399105 | Sea cucumber carotenoid lipid fraction products and methods of use Methods and compositions of matter are described for treatment of inflammatory autoimmune and other diseases by administration of lipid fractions of sea cucumber tissue. Compositions of matter useful for inclusion in aquatic and human diets are also discl... | 06/04/2002 |
| 6296879 | Ruminal fluid inoculation of calves A method to improve the health and growth of suckling dairy calves on dairy farms includes supplementing calves' diets with a ruminal fluid preparation obtained from the rumen of a cow. This supplement provides the calves with the protection needed to dev... | 10/02/2001 |
| 6287605 | Compositions and methods useful in treatment and prevention of HIV-1 infection The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the trea... | 09/11/2001 |
| 6264992 | Submucosa as a growth substrate for cells A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable... | 07/24/2001 |
| 6255502 | Pharmaceutical composition containing acid addition salt of basic drug A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal penetration of the basic drug. The acid addition salts, an inclusi... | 07/03/2001 |
| 6231879 | Biocompatible devices with foam scaffolds This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible material that is loaded with a core made of a reticulate f... | 05/15/2001 |
| 6054142 | Biocompatible devices with foam scaffolds A biocompatible cell device having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule.... | 04/25/2000 |
| 6015878 | Antitumor agents isolated from intestinal mucosa, a method for their isolation and their application This invention provides a method for isolating antitumor agents, inhibiting enterocytogenins, from pig intestinal mucosa. It further provides the antitumor agents, which are nucleopeptides. Additionally the invention provides methods for suppressing the g... | 01/18/2000 |
| 5993806 | Method of stabilizing pharmaceutical preparations comprising digestive enzyme mixtures The use of complex lipids, especially lecithin, as additives to stabilize water-soluble pharmaceutical preparations of digestive enzyme mixtures containing lipases and proteases, especially pancreatin-containing digestive enzyme mixtures, which are suitab... | 11/30/1999 |
| 5948442 | Stimulating ENTEROGENIN compositions and methods for their isolation and use This patent relates to the obtaining of two pharmaceutical forms--pulvis and ampules of the veterinary medical preparation "Enterogenin". The bioactive ingredient of the preparation is isolated by fractionation of pig small intestinal mucosa cell, extract... | 09/07/1999 |
| 5710131 | Inhibitor of collagen-stimulated platelet aggregation A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein p... | 01/20/1998 |
| 5639467 | Electrostatic process for manufacturing coated transplants and product An electrostatic process for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gellable coating polymer solution in a continuous stream through an orifice. The stream is atte... | 06/17/1997 |
| 5510122 | Preparation and use of whole saliva The preparation of a saliva composition substantially viable for therapeutic use in saliva-deficient individuals involves exogenously treating saliva to inactivate microorganisms by contacting with chlorhexidine or ionizing radiation. Pharmaceutically act... | 04/23/1996 |
| 5403596 | Factor Xa inhibitor and pharmaceutical compositions containing same A novel anticoagulant/modulator factor isolated from the saliva of the meinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.... | 04/04/1995 |
| 5384308 | Composition and method for enhancing wound healing There is described herein a wound healing enhancing medicinal composition formulated from the salivary protein Lumicarmine. Lumicarmine is a phosphoglycoprotein with a molecular weight of 34.5 kD. About 80% of the total amino acid residues are proline gly... | 01/24/1995 |
| 5324715 | Protein for inhibiting collagen-stimulated platelet aggregation A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or d... | 06/28/1994 |
| 5304310 | Method for concentrating and purifying hirudin from leeches A method for the concentration and purification of biomolecules is described and comprises introducing the biomolecule into an aqueous/organic solvent system and bringing about a phase separation by addition of salts, where the pH at which the concentrati... | 04/19/1994 |
| 5300306 | Tissue-equivalent membrane from bovine esophageal tissue A ready to use heterograft membrane for replacement of injured skin which is prepared by extraction of a mucous membrane from an esophagus of bovine origin. The tissue-equivalent membrane resulting from this process is applied on burns, cuts or wounds to ... | 04/05/1994 |
| 5246715 | Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of... | 09/21/1993 |
| 5182113 | Factor Xa inibitor from leech and pharmaceutical compositions containing same A novel anticoagulant/modulator factor isolated from the saliva of the medicinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.... | 01/26/1993 |
| 4986988 | Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13 The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13.sup.(1) and a companion substance dehydrodolastatin 13.sup.(2). A series o... | 01/22/1991 |
| 4832849 | Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii Applicant has isolated a Factor Xa inhibiting substance from the salivary gland extract of the leech H.ghilianii. The extract is subjected to separation using both DEAE-cellulose and heparin-agarose chromatography resins eluting with an increas... | 05/23/1989 |
| 4749522 | Supercritical fluid extraction of animal derived materials Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source material, one may obtain lipids, proteins, nucleotides, sacc... | 06/07/1988 |
| 4588587 | Method of treatment to inhibit metastasis Method for treating a patient to inhibit metastasis of malignant cells by administering to the patient a therapeutically effective amount of a composition including a blood anticoagulant and a protease inhibitor. A composition apparently unique for this p... | 05/13/1986 |
| 4407744 | Process for obtaining nerve growth factor A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected t... | 10/04/1983 |
| 4287184 | Process for healing wounds Healing of a wound is accelerated by administering a new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions. The nerve growth factor is obtained from mouse submandibular gland or mouse sa... | 09/01/1981 |
| 4185095 | Nerve growth factor A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected t... | 01/22/1980 |
| 3948875 | Process for the preparation of epidermal growth factor and new derivative using cross-linked polyacrylamide gel at a pH of 1-3 A new procedure has been devised for the preparation of pure epidermal growth factor (EGF) in high yield which involves passing homogenates of submaxillary glands of adult male mice through a polyacrylamide gel column of a low acid pH. Preferably a two st... | 04/06/1976 |
