Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 8137702 | Conformable tissue repair implant capable of injection delivery A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in associ... | 03/20/2012 |
| 8039021 | Bioresorbable polymer matrices and methods of making and using the same A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amou... | 10/18/2011 |
| 7939108 | Method of making demineralized bone particles Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles. ... | 05/10/2011 |
| 7897180 | Enamel matrix protein composition for treatment of systemic inflammatory response The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune response. The composition can be used in preventing and/or treating a ... | 03/01/2011 |
| 7892577 | Bone graft materials derived from mineralized gelatin The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that include such mineralized gelatin carriers including DBM bone products; ... | 02/22/2011 |
| 7875296 | Conformable tissue repair implant capable of injection delivery A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in associ... | 01/25/2011 |
| 7811608 | Tissue repair compositions and methods for their manufacture and use An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction product, separating the insoluble extraction product and the soluble e... | 10/12/2010 |
| 7785634 | Bone graft materials derived from mineralized gelatin The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that include such mineralized gelatin carriers including DBM bone products; ... | 08/31/2010 |
| 7776361 | NELL-1 enhanced bone mineralization This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for modulators of bone mineralization. In addition, NELL-1 can be used to ... | 08/17/2010 |
| 7758895 | Methods for purifying insoluble bone gelatin The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding the bone tissue into bone powder; washing the bone powder with saline... | 07/20/2010 |
| 7754244 | Compositions and methods for treating or preventing hair loss and processes for making the same The present invention relates to composition useful in growing hair. The compositions are particularly suited for re-growing hair in subjects who have experienced hair loss due to any cause. The compositions comprise essentially the lipoidic fraction of mammalian bo... | 07/13/2010 |
| 7608284 | Enamel matrix protein composition for treatment of systemic inflammatory response syndrome The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune response. The composition can be used in preventing and/or treating a ... | 10/27/2009 |
| 7399739 | Vertebral augmentation composition and method A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the norma... | 07/15/2008 |
| 7371409 | Bone graft substitute composition A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, an... | 05/13/2008 |
| 7371410 | Bone graft substitute composition A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, an... | 05/13/2008 |
| 7371408 | Bone graft substitute composition A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium chloride, and sodium sulfate; and a plasticizing substance selected from the ... | 05/13/2008 |
| 7357947 | Bone graft material incorporating demineralized bone matrix and lipids One embodiment of the invention is demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty a... | 04/15/2008 |
| 7341999 | Povidone-containing carriers for polypeptide growth factors A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic tissues. The liquid medium comprises an aqueous solution of polyvinyl ... | 03/11/2008 |
| 7335381 | Transplantable particulate bone composition having high osteoinductive capacity and methods for making and using same A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of al... | 02/26/2008 |
| 7323193 | Method of making demineralized bone particles Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles. ... | 01/29/2008 |
| 7316822 | Conformable tissue repair implant capable of injection delivery A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in associ... | 01/08/2008 |
| 7304030 | Matrix protein composition for dentin regeneration The present invention relates to the surprising finding that enamel matrix, enamel matrix derivatives and/or enamel matrix proteins induce dentin regeneration. The invention thus relates to the use of a preparation of an active enamel substance for the preparation o... | 12/04/2007 |
| 7300465 | Intervertebral allograft spacer An allogenic intervertebral implant for fusing vertebrae is disclosed. The implant is a piece of allogenic bone conforming in size and shape with a portion of an end plate of a vertebra. The implant has a wedge-shaped profile to restore disc height and the natural c... | 11/27/2007 |
| 7294352 | Matrix protein composition for treating inflammation Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation. ... | 11/13/2007 |
| 7291179 | Bone graft substitute composition Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first mixture having calcium sulfate hemihydrate and a plasticizing material t... | 11/06/2007 |
| 7264966 | Method of isolating cell or sample to be analyzed in cell There is disclosed a method of irradiating a specimen which is laid on a substrate and which includes a cell with a laser beam to remove an unnecessary specimen portion other than a cell portion from the substrate, next inserting the cell portion into one opening in... | 09/04/2007 |
| 7241874 | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultr... | 07/10/2007 |
| 7238186 | Interbody fusion device and method for restoration of normal spinal anatomy An interbody fusion device in one embodiment includes a tapered body defining a hollow interior for receiving bone graft or bone substitute material. The body defines exterior threads which are interrupted over portions of the outer surface of the device. The fusion... | 07/03/2007 |
| 7226615 | Expandable foam-like biomaterials and methods Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The... | 06/05/2007 |
| 7208179 | Methods for treating disease and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one oligonucleotide. The composition may be further supplemented with, for examp... | 04/24/2007 |
| 7179492 | Traditional chinese pharmaceutical formulation for treatment of paradentosis, process for preparation and use thereof This invention involves a traditional Chinese medical preparation, its preparation and use. The present Chinese medicine that treats periodontitis is a pharmaceutically acceptable oral preparation containing fleece-flower, dried rehmanria, licorice, fresh-water turt... | 02/20/2007 |
| 7176284 | Osteogenic proteins Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying... | 02/13/2007 |
| 7132110 | Tissue repair compositions and methods for their manufacture and use An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction product, separating the insoluble extraction product and the soluble e... | 11/07/2006 |
| 7109300 | Extraction of collagen from calcified tissues A method is disclosed for extracting collagen from calcified tissue without a prior decalcification step. The method may be used with calcified tissues such as fish skin with scales, alligator skeletons, and crustacean exoskeletons. It does not require the use of ED... | 09/19/2006 |
| 7108721 | Tissue regrafting The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and then removing the scaffold from the mammal. The scaffold is implanted in... | 09/19/2006 |
| 7101545 | Method for using human intervertebral disc cells There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a growth factor, or a cytokine or a bioactive agent to form monolayer pr... | 09/05/2006 |
| 7081240 | Protein mixtures for wound healing A protein mixture that is useful in the treatment of wounds, where the mixture is isolated from bone or is produced from recombinant proteins and may include two or more of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, TGF-β1, TGF-β2, TGF-β3, and FGF-1. ... | 07/25/2006 |
| 7033611 | Matrix protein compositions for guided connective tissue growth The present invention relates to the use of enamel matrix, enamel matrix derivatives and/or enamel matrix proteins as therapeutic and/or cosmetic agents. These substances are used for the manufacture of a pharmaceutical and/or cosmetic composition for actively induc... | 04/25/2006 |
| 7022347 | Restorative and grafting material for hard tissue defects prepared from animal teeth The restorative and grafting material for reconstruction of hard tissue defects and the fabrication method of the same are provided. In particular, the restorative and grafting material of this invention is produced by the steps of cleansing, decoloration (bleaching... | 04/04/2006 |
| 7008634 | Cell growth substrates with tethered cell growth effector molecules Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substr... | 03/07/2006 |
