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| Number | Title | Issue Date |
| 7824712 | Method for reducing the likelihood of implantation failure during an assisted reproduction in a subject in need thereof Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The compositions, kits and methods provide an effective amount of granulocyte colo... | 11/02/2010 |
| 7393628 | Method for enriching adherent monocyte populations The present invention provides methods and apparatus for the rapid and efficient collection and purification of activated monocytes. The methods and apparatus of the present invention provide means for effecting the collection and purification in an aseptic environm... | 07/01/2008 |
| 7364729 | Method of inducing a CTL response Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL ... | 04/29/2008 |
| 7232566 | Methods for treating HIV infected subjects Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 06/19/2007 |
| 7179447 | Type I interferon-producing cells and uses thereof The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising interferon-producing cells (IPCs) and methods of administering the I... | 02/20/2007 |
| 7175843 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 02/13/2007 |
| 7169547 | High concentration white blood cells as a therapeutic product A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagul... | 01/30/2007 |
| 7160726 | Compositions comprising conditioned cell culture media and uses thereof The invention relates to compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture. The cells used to condition the medium may be genetically modified to alter the concentration of growth factors and antioxidants in the medi... | 01/09/2007 |
| 7144575 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 12/05/2006 |
| 7109031 | Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resul... | 09/19/2006 |
| 7105093 | Processing set and methods for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre... | 09/12/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7078034 | In vitro activated γ δ lymphocytes Patients who develop increased numbers of γδ+ cytotoxic T lymphocytes 2–6 months after allogeneic bone marrow transplantation are less likely to relapse than those who do not. The γδ+ T cells isolated from blood of patients with increased γδ+ T cells are CD3... | 07/18/2006 |
| 7041302 | Therapeutic modulation of the tumor inflammatory response The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1 inflammatory response in the tumor tissue, whereby the tumor tissue is d... | 05/09/2006 |
| 6994851 | Method of inducing a CTL response A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained period of time using, e.g., an osmotic pump. The method is advantageou... | 02/07/2006 |
| 6977074 | Method of inducing a CTL response Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL ... | 12/20/2005 |
| 6929796 | Methods to treat undesirable immune responses Isolated and purified peptides and variants thereof, useful to prevent or treat antibody-mediated diseases, or indications caused by an undesirable antibody response to a given antigen, are provided. Also provided are peptides and methods useful to prevent or treat ... | 08/16/2005 |
| 6905680 | Methods of treating HIV infected subjects Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 06/14/2005 |
| 6905681 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 06/14/2005 |
| 6899863 | Method for preparing membrane vesicles This invention relates to a method of preparing membrane vesicles from a biological sample, characterised in that it comprises at least one anion exchange and/or gel permeation chromatography treatment of the sample. The invention is used to prepare vesicles of vari... | 05/31/2005 |
| 6887466 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 05/03/2005 |
| 6855489 | Systems and methods for removing viral agents from blood Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter... | 02/15/2005 |
| 6844011 | Methods for inhibiting rejection of transplanted tissue A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response... | 01/18/2005 |
| 6783987 | Method for obtaining components from cultured leucocyte A method for obtaining leucocyte components from human blood including (A) a first step for fracturing the cell membrane of leucocytes of human blood by using a freezing and defrosting method, a supersonic application, laser irradiation, an osmotic pressure changing... | 08/31/2004 |
| 6713056 | Combined preparation for the treatment of neoplasic diseases or of infectious diseases The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts: monocyte derived cells, particularly cytotoxic macrophages, chemotherapy or immunotherapy drugs, for the simultan... | 03/30/2004 |
| 6713053 | Use of IL-7 for treating auto-immune diseases and insulin-dependent diabetes mellitus in particular The use of interleukin 7 or T cells pre-incubated in the presence of IL-7 for preparing a drug or pharmaceutical composition for treating an auto-immune disease, particularly an auto-immune disease induced by a defect in CD4+ T cell immunoregulation, is disclosed. | 03/30/2004 |
| 6696092 | Endothelial lining effects and treatment of vasospastic disorders Vasospastic disorders are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in ... | 02/24/2004 |
| 6686332 | Method of treating depressed reticuloendothelial system function The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from depressed reticuloendothelial system function an effective ... | 02/03/2004 |
| 6673832 | Methods for identifying compounds for treating pain The invention provides a method of determining whether a compound alleviates vasoconstriction-independent nerve pain mediated by endothelin-1 (ET-1). The method involves (i) determining whether the compound has the ability to inhibit a vasoconstriction-in... | 01/06/2004 |
| 6669965 | Method of treating atherosclerosis A method of treating or preventing atherosclerosis in a mammalian subject comprises: (a) extracting the aliquot of blood from the subject; (b) treating the aliquot of blood ex vivo with at least one stressor selected from the group consisting of an oxidiz... | 12/30/2003 |
| 6653063 | Hematology composition using preserved white blood cells in combination with source particles to simulate native white blood cells and method of making same A hematology control composition and method of making the composition is provided. The control employs a plurality of components including a synthetic plasma component, a red blood cell component, a platelet component and a leukocyte component. The leukoc... | 11/25/2003 |
| 6632622 | Assay for evaluation of cellular response to allergens An assay method for detecting the response or activation of cells, including lymphocytes, and a method for detecting immunological sensitization in a subject, which involves the introduction of cell-activating substance which causes an enzyme of the cells... | 10/14/2003 |
| 6596691 | Therapeutic uses of BPI protein products for human meningococcemia Methods and materials for the treatment of human meningococcemia are provided in which therapeutically effective amounts of BPI protein products are administered.... | 07/22/2003 |
| 6593457 | Lymphocyte-derived antimicrobial protein (LDAP) and methods of isolating and producing and using the protein A purified, soluble lymphocyte-derived antimicrobial protein that has a molecular weight of 16 kD on SDS-PAGE, is inactivated by heating at 56° C. for 30 minutes or by treatment with trypsin, is expressed by CD3-, CD2+ cytokine-stimulated cells', and is ... | 07/15/2003 |
| 6589526 | Enrichment of dendritic cells from blood A method for the enrichment of dendritic cells from the peripheral blood of a mammal is described. Peripheral blood having mononuclear cells from a mammal is provided. The mononuclear cells are separated from the peripheral blood. The mononuclear cells ar... | 07/08/2003 |
| 6586400 | Human therapeutic uses of BPI protein products Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and hematologically verifiable alleviation of endotoxin mediated in... | 07/01/2003 |
| 6534055 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation oc... | 03/18/2003 |
| 6497876 | Method of stimulating an immune response with activated dendritic cells Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols. Other cytokines can be used in separate, sequential or simulta... | 12/24/2002 |
| 6485928 | Use of granulysin as an antimicrobial agent The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population. Of particular interest is the use of the active fragment ... | 11/26/2002 |
| 6362003 | Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sampl... | 03/26/2002 |
