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| Number | Title | Issue Date |
| 8105632 | Cell-derived microparticles as hemostatic agents for control of hemorrhage and treatment of bleeding disorders Compositions comprising membrane-derived and synthetic microparticles that induce platelet aggregation and are useful for treating bleeding disorders, particularly those involving platelet dysfunction. Microparticles include endothelial derived microparticles (EMP),... | 01/31/2012 |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7358284 | Particulate acellular tissue matrix A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resul... | 04/15/2008 |
| 7358039 | Fixed-dried red blood cells Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenici... | 04/15/2008 |
| 7291592 | Method for treating patients with massive blood loss Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution. ... | 11/06/2007 |
| 7267817 | Method for improving oxygen transport by stored red blood cells A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solutio... | 09/11/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7186559 | Apparatus and method for electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 03/06/2007 |
| 7169547 | High concentration white blood cells as a therapeutic product A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagul... | 01/30/2007 |
| 7169606 | Lyophilization of human platelets A protectant mixture for use in preserving biological materials comprising at least one polyhydroxy compound, and phosphate ions; a preservation medium comprising a biological material, at least one polyhydroxy compound, and phosphate ions; methods of preserving the... | 01/30/2007 |
| 7166278 | Modified organs and cells for xenotransplantation It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galac... | 01/23/2007 |
| 7141425 | Apparatus and method for electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 11/28/2006 |
| 7135553 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 11/14/2006 |
| 7122531 | Regulation of intracellular glucocorticoid concentrations This invention relates to the interconversion of inactive 11-keto steroids with their active 11B-hydroxy equivalents, to methods by which the conversion of the inactive to the active form may be controlled, and to useful therapeutic effects which may be obtained as ... | 10/17/2006 |
| 7112576 | Compositions and methods for cryopreservation of peripheral blood lymphocytes A composition and method for cryopreserving cells in a non-toxic medium is described. The composition and method provide cells for cell therapy and other in vivo applications. ... | 09/26/2006 |
| 7105093 | Processing set and methods for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre... | 09/12/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7084115 | Inositol pyrophosphates, and methods of use thereof The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention rela... | 08/01/2006 |
| 7049110 | Inactivation of West Nile virus and malaria using photosensitizers Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic a... | 05/23/2006 |
| 7029916 | Apparatus and method for flow electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 04/18/2006 |
| 7025877 | Processing set for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre... | 04/11/2006 |
| 7011797 | Apparatus for thawing frozen biological fluids utilizing heating plates and oscillatory motion to enhance heat transfer by mixing An improved dry heat method and apparatus for thawing frozen biological fluids utilizing electrically heated plates and oscillatory motion to enhance heat transfer by mixing as the fluid thaws. Bags of frozen fluid to be thawed are lightly squeezed between two heati... | 03/14/2006 |
| 7001715 | Purification of red blood cells by separation and diafiltration Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent coagulation prior to separation. Preferably, the whole blood is bovi... | 02/21/2006 |
| 6960464 | Methods for lyophilizing competent cells This invention relates to a method for producing cells which are competent for transformation and which may be stably stored for extended periods of time at various temperatures. The method involves growing cells in a growth conducive medium, rendering said cells co... | 11/01/2005 |
| 6924498 | Sample collection and testing system Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or a process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other paramete... | 08/02/2005 |
| 6811778 | Method for improving oxygen transport by stored red blood cells A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solutio... | 11/02/2004 |
| 6653063 | Hematology composition using preserved white blood cells in combination with source particles to simulate native white blood cells and method of making same A hematology control composition and method of making the composition is provided. The control employs a plurality of components including a synthetic plasma component, a red blood cell component, a platelet component and a leukocyte component. The leukoc... | 11/25/2003 |
| 6498141 | Method and apparatus for preparing an acellular red blood cell substitute A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin ... | 12/24/2002 |
| 6387353 | Light or heat activated dental bleaching compositions Dental bleaching compositions are made with a bleaching agent and a stable radiant-energy absorbing compound that acts as a bleaching agent activator. The dental bleaching compositions of the present invention can be one-part, pre-mixed compositions that ... | 05/14/2002 |
| 6362003 | Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sampl... | 03/26/2002 |
| 6303152 | Process for the production of substances that have been bactericidally treated and/or exhibit immune-modulatory activity, and the use thereof A process is disclosed for the production of immune-genetically active suspensions of which the initial substances are fluids or tissues from the human or animal body. Autohemotherapy, immune-stimulatory and/or immune-suppressive effects are employed. The... | 10/16/2001 |
| 6267925 | Method for cryopreservation and recovery of red blood cells A system dynamically adjusts the delivery rate of a cryopreservation solution to red blood cells to permit freezing. The delivery rate is preferably determined according to an equation that maintains a linear change of red blood cell osmolarity over time ... | 07/31/2001 |
| 6231879 | Biocompatible devices with foam scaffolds This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible material that is loaded with a core made of a reticulate f... | 05/15/2001 |
| 6177106 | Method for fractionating red blood cells and antibacterial materials for bacterial proliferation inhibitors produced thereby A method for fractionating red blood cells of human blood into three fractions comprises following steps; (a) human blood sample is mixed with dextran aqueous solution and maintained stationarily for 60 to 75 min to fractionate this blood sample into thre... | 01/23/2001 |
| 6139878 | Method for preparing a diafiltered stabilized blood product A method using diafiltration to prepare a blood product is described. The method removes contaminating plasma proteins from whole blood or blood products. Diafiltration may be used on paraformaldehyde-fixed platelets to remove formaldehyde to undetectable... | 10/31/2000 |
| 6117838 | Use of hemoglobin in the treatment of hypotension A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 09/12/2000 |
| 6114306 | Cytokine related to hemolytic anemia and method of use Pyruvate kinase deficiency is a blood disease characterized by hemolytic anemia. PCR analysis of cDNA leukocytic extracts of patients with hereditary pyruvate kinase deficiency anemia revealed two overexpressed markers when compared to extracts from healt... | 09/05/2000 |
| 6090779 | Use of hemoglobin to treat septic shock Therapeutic treatment of septic shock comprises administering to an animal stroma-free hemoglobin, typically at a dose ranging from the least amount effective to increase perfusion, up to a dosage of about 2500 milligrams kilograms per of body weight.... | 07/18/2000 |
| 6046161 | Use of hemoglobin in the treatment of cardiogenic shock A method for increasing perfusion in a mammal suffering from cardiogenic shock by administering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 04/04/2000 |
| 6030768 | Analysis of conformational changes in band 3 protein as a method for diagnosing Alzheimer's disease A method diagnosing Alzheimer's disease in a patient includes analyzing conformational changes in a band 3 protein of the patient yielding a time course of the conformational changes. One approach includes analyzing conformational changes in a band 3 prot... | 02/29/2000 |
