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| Number | Title | Issue Date |
| 8349367 | Freeze-dried plasma formats for the trauma care field Disclosed are freeze-dried plasma formats specifically designed for the trauma care field. Blood plasma is subjected to a glucose removal step, a protein fraction up-concentration step and addition of stabilizers prior to freeze-drying. Preferable stabilizers are gl... | 01/08/2013 |
| 8303993 | Methods of applying a biological composition to an individual The present relates to an autologous bioadhesive sealant composition, or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platele... | 11/06/2012 |
| 8293281 | Analgesic and anti-inflammatory composition The present invention discloses a composition that contains (1) an effective amount of an analgesically and/or anti-inflammatory active fraction separated from a mixture of plasma and/or serum, and (2) at least one metal, metal ion or metal salt, in which the mixtur... | 10/23/2012 |
| 8236355 | COX-2 inhibitor The present invention relates to an agent having COX-2 inhibition activity. In particular the present invention relates to a COX-2 inhibitor separated from a mixture of denatured plasma and at least one metal, metal ion or metal salt thereof. ... | 08/07/2012 |
| 8168229 | Methods for making a multicomponent hemostatic dressing A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredie... | 05/01/2012 |
| 8092837 | Fibrin based glue with functionalized hydrophilic polymer protein binding agent The present invention provides a non-liquid biomaterial that may be used as a surgical sealant, a suture support, a blood flow controller, an adhesion reducing agent, an adhesion preventing agent, a tissue support, a tissue filler, a wound dressing or a combination ... | 01/10/2012 |
| 8017157 | Method of treating a wound with acidified plasma or serum The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site... | 09/13/2011 |
| 7931919 | Method of producing glycine-stabilized, lyophilized plasma The invention is directed to stabilized whole-cell plasma, which retains the integrity and overall stability of the proteins and other macromolecules of the plasma. Stabilization is accomplished by the addition of glycine to plasma which allows for stabilization pri... | 04/26/2011 |
| 7867519 | Method for the acceleration or deceleration of angiogenesis using fibrin matrix formed from increased or decreased HMW/LMW fibrinogen ratio A method for modifying the properties of a fibrin matrix relative to growth and ingrowth of cells, wherein for forming the fibrin matrix a fibrinogen is used consisting of a selected fibrinogen variant or a fibrinogen enriched or depleted in a selected fibrinogen va... | 01/11/2011 |
| 7838039 | Autologous fibrin sealant and method for making same Provided are methods of applying biological compositions, that is, autologous bioadhesive sealant compositions containing one or more biological agents, to an individual, wherein all the blood components used in preparing the composition are derived from the patient... | 11/23/2010 |
| 7811607 | Autologous fibrin sealant and method for making the same The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet... | 10/12/2010 |
| 7662411 | Process for removal of solvent and detergent from plasma The present invention relates to a process of disinfecting biological materials. In particular, a novel process is provided for removing detergent and/or solvent added to biological materials for the inactivation of viral contaminants. Safe, efficient, and economica... | 02/16/2010 |
| 7641918 | Plasma cryoprecipitate substantially free of plasminogen A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group... | 01/05/2010 |
| 7510732 | Analgesic and anti-inflammatory composition The present invention discloses a composition that contains (1) an effective amount of an analgesically and/or anti-inflammatory active fraction separated from a mixture of plasma and/or serum, and (2) at least one metal, metal ion or metal salt, in which the mixtur... | 03/31/2009 |
| 7442308 | Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process A process for removing viruses in fibrinogen solutions and fibrinogen obtained thereof wherein the process starts with an adjusted purified fibrinogen solution, the adjusted purified solution is frozen and then thawed at a temperature between 5 and 20° C., the undi... | 10/28/2008 |
| 7351422 | Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic action of blood platelets and fibrin and cell adhesion to the trauma s... | 04/01/2008 |
| 7348411 | Process for manufacturing fibrin membranes and fibrin membranes obtained according to this process A process for manufacturing a fibrin membrane from blood plasma that was partially depleted and subjected to coagulation by adding a solution of a physiological coagulating agent, leaving the mixture to stay until forming a gelatinous blood clot, and then dehydratin... | 03/25/2008 |
| 7235255 | Biological bioadhesive compositions and methods of preparation and use The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is form... | 06/26/2007 |
| 7229633 | Biological bioadhesive compositions and methods of preparation and use The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is form... | 06/12/2007 |
| 7208179 | Methods for treating disease and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one oligonucleotide. The composition may be further supplemented with, for examp... | 04/24/2007 |
| 7182962 | Immunostimulator for animals and humans, and method of preventing animal and human infectious diseases and cancer The goal of the present invention is to provide substances to prevent diseases by activating inherently possessed functions, for cultured fishes and shellfishes and livestock with tendency of decreased immune function due to densely populated breeding environment, a... | 02/27/2007 |
| 7182744 | Method and apparatus for aneurismal treatment An irritant or polymer is dispensed to the inner surface area of an aneurysm to exert a contractile force on the inner surface area of the aneurysm, thereby shrinking the aneurysm. As a result, the artery wall at the aneurysm site is strengthened, the risk of ruptur... | 02/27/2007 |
| 7169547 | High concentration white blood cells as a therapeutic product A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagul... | 01/30/2007 |
| 7125569 | Removal of plasmin(ogen) from protein solutions A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group... | 10/24/2006 |
| 7115559 | Method for treating coumarin-induced hemorrhage Use of factor XIII for treating coumarin-induced hemorrhage or bleeding. The coumarin may be warfarin or dicoumarol. A patient having coumarin-induced bleeding is treated with factor XIII alone or in conjunction with vitamin K. ... | 10/03/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7056722 | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined compone... | 06/06/2006 |
| 7041302 | Therapeutic modulation of the tumor inflammatory response The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1 inflammatory response in the tumor tissue, whereby the tumor tissue is d... | 05/09/2006 |
| 7015198 | Materials for soft tissue augmentation and methods of making and using same Materials for soft tissue augmentation in mammals are prepared by cross-linking blood plasma proteins, preferably with a zero-length cross-linking agent. The cross-linked blood plasma proteins can be dialyzed and autoclaved. Such materials are non-antigenic, exhibit... | 03/21/2006 |
| 6992061 | Purification method The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprot... | 01/31/2006 |
| 6942880 | Autologous platelet gel having beneficial geometric shapes and methods of making the same The present invention relates to the production of platelet gels formed into beneficial geometric shapes. Specifically the present invention provides a simpler way to introduce platelet gel for specific uses, such as into the cavity of a gum left after a tooth extra... | 09/13/2005 |
| 6936267 | Anti-acne compositions and methods of use The present invention relates to a composition for the treatment of acne comprising chlorine dioxide or chlorine dioxide generating compounds as acne reduction agents. The invention also relates to a method for treating acne by topically administering one of the com... | 08/30/2005 |
| 6899813 | Method for the production of a blood component composition A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first co... | 05/31/2005 |
| 6855489 | Systems and methods for removing viral agents from blood Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter... | 02/15/2005 |
| 6830762 | Autologous fibrin sealant and method for making the same The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet... | 12/14/2004 |
| 6831157 | Process for the purification of serum albumin Recombinantly produced serum albumin is purified in a series of steps, optionally by incubation with an anion-exchange adsorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueou... | 12/14/2004 |
| 6783775 | Serum-derived factor inducing cell differentiation and medical uses thereof The present invention relates to a biologically active serum-derived composition of matter (SDF), having a low molecular weight, being electrically charged at acidic pH and having absorption at 280 nm. The molecular weight of said SDF was determined by electron spra... | 08/31/2004 |
| 6770278 | Methods of making and using immunoglobulin (Ig) compositions The invention is directed to methods of using Ig compositions to prevent and/or treat humans, livestock and/or domesticated animals suffering from stress induced respiratory disorders. The Ig composition comprises a concentrated amount of one or more immunoglobulins... | 08/03/2004 |
| 6709413 | Platelet gel manufacturer for use in a closed corporeal circuit The platelet gel manufacturer includes a platelet gel applicator, a controllable platelet receptacle, a controllable coagulant receptacle, and a controllable platelet gel receptacle. The controllable platelet receptacle is fluidly coupled to the closed corporeal sys... | 03/23/2004 |
| 6695805 | Systems and methods for removing free and entrained contaminants in plasma Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The sy... | 02/24/2004 |
