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| Number | Title | Issue Date |
| 6514515 | Bioabsorbable, biocompatible polymers for tissue engineering Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or ten... | 02/04/2003 |
| 6514504 | Discontinuous films from skin care compositions The present invention relates to substantially uniform, discontinuous films of a skin care product having a defined average particle size, particle spacing and coverage value. The films provide improved skin appearance, e.g., good apparent coverage and a ... | 02/04/2003 |
| 6511681 | Aqueous solubility pharmaceutical formulations A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is ... | 01/28/2003 |
| 6509037 | Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof The present invention provides a novel sustained release composition and method for making such a composition of diclofenac and its pharmaceutically acceptable salts. The composition of the present invention provides a sustained release formulation of dic... | 01/21/2003 |
| 6509025 | Method of producing an impact resistant solid cosmetic composition A method is provided for producing an impact resistant solid cosmetic such as cheek rouge, powder, foundation and two way foundation by compacting powder materials into a dish mold. The powder materials are compression molded into a dish mold under a pres... | 01/21/2003 |
| 6506411 | Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also, provi... | 01/14/2003 |
| 6506410 | Sustained release microparticle and method for preparing the same Disclosed is a method for preparing sustained release microparticles which release a physiologically active substance for long periods of time. The sustained release microparticles are prepared through a multi-emulsion process. A drug of interest is disso... | 01/14/2003 |
| 6500463 | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles A solid active, sensitive encapsulant and/or a liquid encapsulant component which contains an active, sensitive encapsulant, is admixed with at least one plasticizable matrix material, a matrix component which is substantially non-plasticizable at tempera... | 12/31/2002 |
| 6500448 | Composition for sustained release of human growth hormone A pharmaceutical composition for the sustained release of human growth hormone from a polymer matrix is disclosed. The pharmaceutical composition comprises a biocompatible polymer, particles of metal cation-complexed human growth hormone wherein said part... | 12/31/2002 |
| 6497905 | Aqueous solubility pharmaceutical formulations A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is ... | 12/24/2002 |
| 6491953 | Controlled release compositions and method A controlled release composition comprising an adsorbent polymer, an active agent, and a release retardant is disclosed. The composition has an improved ability to release the active agent over an extended time period.... | 12/10/2002 |
| 6488952 | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic applications is provided which includes a biocompatible semisolid delivery system and a biocompatible combination semisolid, mu... | 12/03/2002 |
| 6489103 | In vitro sorting method The invention relates to a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to pro... | 12/03/2002 |
| 6485737 | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles and methods of using the same A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic or heterocyclic residue; x is ࣙ1; and ... | 11/26/2002 |
| 6485741 | Granulate with high content of L-carnitine or an alkanoyl L-carnitine A granulate is described containing granules of an active ingredient endowed with therapeutic/nutritional activity coated with a granulating/bonding agent, suitable for conversion into a solid administration form with a very high content of active ingredi... | 11/26/2002 |
| 6485738 | Delivery system for enhanced bioavailability of nutrients and supplements A gel delivery system for promoting bioavailability and uptake of vitamins, minerals and other nutritional supplements comprises a gel base, preferably including agar, water and a bioavailablity enhancing composition that promotes absorption of the carrie... | 11/26/2002 |
| 6482516 | Enrobed tablet A medicine tablet is described as a new article of manufacture. The tablet is enrobed in a gelatin coating formed by application of respective layers of elastic gelatin film to opposite sides of the tablet. The applied gelatin layers conform tightly to th... | 11/19/2002 |
| 6475507 | Sustained release compositions and the process for their preparation The invention relates to compositions in the form of microcapsules or implants comprising a biodegradable polymeric or copolymeric excipient or a mixture of such excipients with an inherent viscosity of between 0.5 dl/g and 1.6 dl/g in CHCl3, a... | 11/05/2002 |
| 6475496 | Gelled cosmetic remover composition An organic solvent based cosmetic remover composition gelled to a viscosity of 25 to 500,000 centipoise with a synthetic metal silicate gelling agent.... | 11/05/2002 |
| 6471996 | Biodegradable targetable microparticle delivery system Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of -hydroxy acid subunits such as D,L-lactide and -a... | 10/29/2002 |
| 6471995 | Apparatus and method for preparing microparticles using liquid-liquid extraction Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted ... | 10/29/2002 |
| 6471952 | Cosmetic composition including at least one silicone-grafted polymer and at least one combination of an anionic polymer and a cationic polymer A cosmetic or dermatological composition for treating keratinous material, particularly hair, including a cosmetically or dermatologically acceptable medium containing as least one silicone-grafter polymer with a polysiloxane portion and a portion consist... | 10/29/2002 |
| 6465017 | Process for the preparation of solid oral dosage forms comprising alendronic acid The present invention relates to a process for preparing solid oral dosage forms e.g. tablets,capsules,coated tablets/capsules, etc. comprising as active ingredient 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid or one of its pharmaceutically acceptab... | 10/15/2002 |
| 6465011 | Formulations comprising lipid-regulating agents The present invention is directed to a solid formulation comprising the lipid-regulating agent dispersed in a hydrophilic, amorphous polymer in which said lipid-regulating agent is present as a meta-stable, amorphous phase.... | 10/15/2002 |
| 6461631 | Biodegradable polymer composition A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent ... | 10/08/2002 |
| 6462093 | Method for converting sparingly water-soluble medical substance to amorphous state A process for producing a solid dispersion of a sparingly water-soluble medical substance which comprises subjecting the sparingly water-soluble medical substance, an amorphous state-inducing agent and an amorphous state-stabilizing agent to heat treatmen... | 10/08/2002 |
| 6455074 | Methods for fabricating polymer-based controlled release devices The present invention relates to a polymer-based sustained release device, and methods of forming and using the device for the sustained release of an active agent. The improved method of the invention for forming a polymer-based sustained release device ... | 09/24/2002 |
| 6451345 | Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration The present invention provides taste-masked microcapsules of Linezolid or the like (any member of the orally effective oxazolidinone or macrolide antibiotics), suitable for oral administration as a suspension, a fast-disintegrating, effervescent or chewab... | 09/17/2002 |
| 6440461 | Poly(methylidene malonate) microspheres, preparation method and pharmaceutical compositions containing them The invention concerns novel microspheres particularly useful in pharmaceutics as particulate vectors for carrying biologically active substances, in particular hydrophilic substances, for oral administration. The invention is characterised in that said m... | 08/27/2002 |
| 6440462 | Agglomerates of ଲ-lactam antibiotics and processess for making agglomerates Agglomerates of ଲ-lactam antibiotics, such as penicilllin V potassium, amoxicillin trihydrate, cephalexin monohydrate, which are suitable for direct tablet formation.... | 08/27/2002 |
| 6436424 | Injectable and swellable microspheres for dermal augmentation The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention fu... | 08/20/2002 |
| 6433040 | Stabilized bioactive preparations and methods of use Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variatio... | 08/13/2002 |
| 6432451 | Film coated microbeads containing active compounds and method of making the same Disclosed is a composition for use in dermal application. The composition includes microbeads or chemically stable particles having an internal structure of pores. A chemical compound having a pharmaceutical or cosmetic activity is retained in the interna... | 08/13/2002 |
| 6432381 | Methods for targeting drug delivery to the upper and/or lower gastrointestinal tract Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.... | 08/13/2002 |
| 6428815 | Method of producing sub-micron particles of biologically active agents and uses thereof Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce f... | 08/06/2002 |
| 6428813 | Gastrointestinal mucosa-adherent pharmaceutical composition In order to provide a composition having a long gastroduodenal residence time and exhibiting an improved efficacy, is provided a gastrointestinal mucosa-adherent composition comprising an active ingredient and a material which swells a viscogenic agent ca... | 08/06/2002 |
| 6428814 | Bioadhesive nanoparticulate compositions having cationic surface stabilizers Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticle... | 08/06/2002 |
| 6426317 | Stable, high available halogen 1,3,5-triazine-2,4,6-trione compositions having rapid dissolution rates Dry, stable, high available halogen sanitizing granular compositions with a rapid rate of dissolution comprising halogenated 1,3,5-triazine-2,4,6-triones and a dissolution accelerant that is an alkali metal salt of 1,3,5-triazine-2,4,6-trione are disclose... | 07/30/2002 |
| 6423345 | Matrices formed of polymer and hydrophobic compounds for use in drug delivery A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as "hydrophobic compounds") is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the d... | 07/23/2002 |
| 6423339 | Liquisolid systems and methods of preparing same A method of producing a free flowing and compressible liquid/power admixture of an active drug substance, by converting the active substance into a liquisolid system. This is accomplished by introducing by the drug into a non-volatile liquid or a mixture ... | 07/23/2002 |
