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| Number | Title | Issue Date |
| 7335391 | Method for coating implantable devices A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. ... | 02/26/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7329413 | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof Coatings for implantable medical devices, and methods for fabricating thereof, are provided. The coatings include a first polymer layer and a second polymer layer, where the second polymer has a higher degree of hydration than the first polymer. ... | 02/12/2008 |
| 7323190 | Cell delivery system comprising a fibrous matrix and cells Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and ... | 01/29/2008 |
| 7318932 | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same A polymer coating for medical devices based on a derivatized poly(ethylene-co-vinyl alcohol) is disclosed. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include poly(ethylene-co-vinyl a... | 01/15/2008 |
| 7311980 | Polyactive/polylactic acid coatings for an implantable device A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided. ... | 12/25/2007 |
| 7309757 | Polymers for the delivery of bioactive agents and methods of their preparation Provided is a poly(amino ester) having a polymer backbone comprising at least one secondary amine linkage and at least one tertiary amine linkage in the polymer backbone. Poly(amino ester)s are prepared via the Michael addition of a bis(acrylate ester)monomer to a d... | 12/18/2007 |
| 7304122 | Elastomeric functional biodegradable copolyester amides and copolyester urethanes The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are u... | 12/04/2007 |
| 7300671 | Method and apparatus for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mix... | 11/27/2007 |
| 7299587 | Method and apparatus for controlling pests A method of controlling pests, such as insects, by trapping and/or killing them wherein at least a part of a pest to be trapped or killed is exposed a composition comprising particles containing or consisting of at least one magnetic material. ... | 11/27/2007 |
| 7291348 | Compositions and methods for biodegradable microspheres as carriers of bioactive substances A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to n... | 11/06/2007 |
| 7288319 | Forming a chemically cross-linked particle of a desired shape and diameter Chemically cross-linked polymeric particles are formed using mechanical rather than chemical processes, facilitating production of small-diameter particles in a manner largely independent of the viscosity or density of the polymer. For example, an uncross-linked res... | 10/30/2007 |
| 7288267 | Bioadhesive nanoparticulate compositions having cationic surface stabilizers Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biolog... | 10/30/2007 |
| 7285289 | Nanoparticle vaccines The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also displa... | 10/23/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7282338 | Cell migration assay The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers. ... | 10/16/2007 |
| 7282219 | Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability A powdery preparation for transmucosal administration comprising a medicine of high molecular weight, a cationic polymer and, as needed, a viscous polymer, further comprising an effective amount of a basic amino acid. The powdery preparation for transmucosal adminis... | 10/16/2007 |
| 7282220 | Genipin-crosslinked gelatin microspheres as drug carrier A pharmaceutical microsphere comprises a bioactive agent and a biological carrier that encapsulates the bioactive agent, wherein the biological carrier is crosslinked with a crosslinking agent. ... | 10/16/2007 |
| 7282194 | Nanoparticles for protein drug delivery The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery. ... | 10/16/2007 |
| 7282195 | Flavored sealants A single-component composition for repairing, protecting or sealing teeth comprising a polymerizable resin, a flavoring agent, wherein the flavoring agent is a non-oil containing natural flavoring agent, or an artificial flavoring agent, an ultraviolet light absorbe... | 10/16/2007 |
| 7279174 | Stent coatings comprising hydrophilic additives A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically... | 10/09/2007 |
| 7276254 | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same A method of forming polymeric microspheres for biomedical applications includes forming polymeric microspheres by an emulsion/aggregation process from a precursor monomer species, and treating the polymeric microspheres to attach a biomedical functional material to ... | 10/02/2007 |
| 7262221 | Amphiphilic star-like macromolecules for drug delivery The present invention provides polymeric compounds that can form micelles in solutions. These compounds have a hydrophobic, core that is coupled to a plurality of hydrophilic moieties. ... | 08/28/2007 |
| 7258850 | Methods and compositions for treating erectile dysfunction Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to treat erectile dysfunction or a combination of the testosterone and the ... | 08/21/2007 |
| 7258874 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are de... | 08/21/2007 |
| 7255877 | Fenofibrate microparticles Fenofibrate microparticles are prepared using a combination of surface modifiers with a phospholipid. Particle size growth and stability are controlled while significantly smaller sized fenofibrate particles are produced. ... | 08/14/2007 |
| 7252842 | Induced phase transition method for the production of microparticles containing hydrophilic active agents Microparticles and a method for their production is described. The process of the present invention provides a simple, quick, and efficient one-pot process for the production of microparticles containing a hydrophilic active agent of various and uniform morphologies... | 08/07/2007 |
| 7250177 | Multiblock biodegradable hydrogels for drug delivery and tissue treatment Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue su... | 07/31/2007 |
| 7247319 | Preparation of microparticles having improved flowability Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintain... | 07/24/2007 |
| 7244443 | Polymers of fluorinated monomers and hydrophilic monomers A polymer of fluorinated monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains a polymer of fluorinated monomers and another biocompatible polymer. The polymer of fluorinated monomers or polymer blend described herein and o... | 07/17/2007 |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7241813 | End-capped polymers and compositions containing such compounds End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula: and may be combin... | 07/10/2007 |
| 7229645 | Spray freeze-dried compositions A process for producing a powder comprises spray freeze-drying an aqueous solution or suspension comprising a pharmaceutical agent, said solution or suspension having a solids content of 20% by weight or more. The spray freeze-dried powder may be administered to a s... | 06/12/2007 |
| 7226978 | Techniques to improve polyurethane membranes for implantable glucose sensors The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains wh... | 06/05/2007 |
| 7226617 | Thermosensitive and biodegradable microgel and a method for the preparation thereof The present invention provides a thermosensitive and biodegradable microgel and a method of synthesizing such microgels. The thermosensitive and biodegradable microgel is synthesized from a macromer comprising a thermosensitive block polymer co-polymerized with a bi... | 06/05/2007 |
| 7223419 | Production process for polymeric micelle charged therein with drug and polymeric micelle composition Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a spe... | 05/29/2007 |
| 7223282 | Remote activation of an implantable device The invention is directed to an implantable device, such as a stent, for delivering a therapeutic substance. The device includes a reservoir containing a therapeutic substance and an energy converter to cause the release of the substance. ... | 05/29/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7220434 | Dual-release compositions of a cyclooxygenase-2 inhibitor Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, in an immediate-release fraction and a controlled-release, slo... | 05/22/2007 |
| 7220816 | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same Coatings for an implantable medical devices such as stents and methods of fabricating thereof are disclosed. The coatings comprise a biologically absorbable poly(ester amide), which is a polymeric product of a reaction between a diol-diamine and a dicarboxylic acid.... | 05/22/2007 |
