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| Number | Title | Issue Date |
| 6258297 | Water-redispersible granules including a liquid active material and a non ionic alkoxylated type surfactant Water-redispersible granules including at least one active material in the form of a hydrophobic liquid, at least one non-ionic surfactant selected from polyoxyalkylene derivatives, and at least one water-soluble compound selected from polyelectrolytes be... | 07/10/2001 |
| 6254889 | Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer. ##STR1## (In the above f... | 07/03/2001 |
| 6254890 | Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids The present invention provides biodegradable polymer nanospheres capable of transporting and releasing therapeutic agents, specifically nucleic acids. In preferred embodiments, a sub-150 nm nanosphere is formed containing nucleic acids. Thereafter, the ag... | 07/03/2001 |
| 6254893 | Composition for treating dry eye A calcium-based ophthalmic composition for treating dry eye including a hydrophobic carrier, such as petrolatum, and a calcium salt. Also a method for treating dry eye comprising the step of administering the composition according to the present invention... | 07/03/2001 |
| 6251421 | Pharmaceutical composition containing psyllium fiber and a lipase inhibitor The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of psyllium husk, its seeds and leaves thereof. Methods are pr... | 06/26/2001 |
| 6248364 | Encapsulation process and encapsulated products A process for encapsulating a partially water-miscible organic material within a polyurea or polyurethane shell is provided utilizing a water-soluble tertiary amine in the reaction dispersion. Microcapsules and methods of using microcapsules are also prov... | 06/19/2001 |
| 6238705 | Bioerodible porous compositions A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material wi... | 05/29/2001 |
| 6224909 | Fast decomposing pellets The invention concerns pharmaceutical forms of administration that are in the form of pellets which contain a retarding agent in which the release rate of the active substance is not delayed or is substantially identical compared to corresponding pellets ... | 05/01/2001 |
| 6221397 | Surface cross-linked particles suitable for controlled delivery Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidy... | 04/24/2001 |
| 6221399 | Method of making controlled release particles of complexed polymers A method of making a solid interpolymer for use as a controlled release matrix for a controlled release product for oral administration, involves dissolving a first polymer in a solvent therefor, dissolving one or more second complementary polymers capabl... | 04/24/2001 |
| 6217908 | Bioadhesive microspheres and their use as drug delivery and imaging systems Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres al... | 04/17/2001 |
| 6217893 | Sustained-release compositions and method for preparing same The invention relates to compositions in the form of microcapsules or implants comprising a biodegradable polymeric or copolymeric excipient or a mixture of such excipients with an inherent viscosity of between 0.5 dl/g and 1.6 dl/g in CHCl3, a... | 04/17/2001 |
| 6217912 | Polyester analogue of poly-L-lysine as a soluble, biodegradable gene delivery carrier Poly[-(4-aminobutyl)-L-glycolic acid] (PAGA) is disclosed as a biodegradable composition suitable for delivering a gene into a cell. Methods of making and using PAGA are also disclosed.... | 04/17/2001 |
| 6217911 | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blen... | 04/17/2001 |
| 6214387 | Biodegradable polymer matrices for sustained delivery of local anesthetic agents Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a biodegradable polymer degrading significantly within a mon... | 04/10/2001 |
| 6210717 | Biodegradable mixed polymeric micelles for gene delivery A biodegradable, mixed polymeric micelle used to deliver a selected nucleic acid into a targeted host cell contains an amphiphilic polyester-polycation copolymer and an amphiphilic polyester-sugar copolymer. The polyester-polycation copolymer forms an ele... | 04/03/2001 |
| 6207193 | Transdermal drug delivery system There is disclosed a transdermal drug delivery system wherein a drug or therapeutic agent is encapsulated in a water soluble carbohydrate. The carbohydrate-encapsulated drug or therapeutic agent, in the form of finely divided particles, is suspended in a ... | 03/27/2001 |
| 6203802 | Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by topical application to the skin, and corresponding preparation process Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper layers of the epidermis. The nanoparticles are preferably prepared... | 03/20/2001 |
| 6197346 | Bioadhesive microspheres and their use as drug delivery and imaging systems Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, diagnostic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric mic... | 03/06/2001 |
| 6197350 | Method of producing a sustained-release preparation A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides... | 03/06/2001 |
| 6197349 | Particles with modified physicochemical properties, their preparation and uses Particles comprising (a) a supercooled melt of a poorly water-soluble substance and (b) a stabilizing agent, which have a mean particle size of between 30 and 500 nm, and disperse compositions containing them, as administration forms and delivery systems for d... | 03/06/2001 |
| 6190700 | Production of sustained-release preparation for injection Disclosed is a method of producing a sustained-release preparation for injection, which comprises adding to microspheres which are obtained from w/o emulsion with a solution containing a physiologically active peptide as an internal aqueous phase and a so... | 02/20/2001 |
| 6190702 | Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase A sustained-release preparation containing a bioactive polypeptide is prepared using a starting material containing a lyophilized product of an aqueous solution or suspension of the bioactive polypeptide in a non-ionic surfactant. The lyophilized product ... | 02/20/2001 |
| 6190701 | Composition and method for stable injectable liquids A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, the first component comprises microparticles of sugar glass or a phosphate glass containing the bioactive agent. The sugar glass or... | 02/20/2001 |
| 6183781 | Method for fabricating polymer-based controlled-release devices The present invention includes a method for producing an implantable polymer/drug matrix mass, comprising the steps of (1) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a suspended labile drug; (2) removi... | 02/06/2001 |
| 6159490 | Implants containing bioactive peptides A pharmaceutical implant for the delivery of an effective amount of a bioactive peptide or peptide analog over a period of 1 to 12 months. This implant has a diameter of about 1 to 2 mm, a length of between about 10 and 25 mm and is obtainable from a proc... | 12/12/2000 |
| 6156348 | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability o... | 12/05/2000 |
| 6153225 | Injectable formulations of nanoparticulate naproxen Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxe... | 11/28/2000 |
| 6149843 | Microcapsules containing suspensions of biologically active compounds and ultraviolet protectant Microcapsules containing a biologically active material which is sensitive to ultraviolet light are prepared which contain an ultraviolet light protectant selected from titanium dioxide, zinc oxide and mixtures thereof, suspended and thoroughly dispersed ... | 11/21/2000 |
| 6149944 | Preparation method for biodegradable polymeric microspheres using solvent extraction and preparation method for microspheres for treating local inflammation using the same A preparation method for biodegradable polymeric microspheres using a solvent extraction method for biodegradable polymeric microspheres for treating a local inflammation disease using the same which are capable of effectively curing ozena such as sinusit... | 11/21/2000 |
| 6146663 | Stabilized nanoparticles which may be filtered under sterile conditions This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified... | 11/14/2000 |
| 6132772 | Extended-release solid oral dosage forms of drugs having low solubility in water The present invention relates to extended-release solid oral dosage forms of a drug having low solubility in water are obtained by dissolving the drug in polyethylene glycol having a mean molecular weight of at least 1000 and adding thereto a hydrophilic ... | 10/17/2000 |
| 6132749 | Sustained release pheromone-containing preparations A sustained release pheromone-containing preparation is obtained by incorporating a sex pheromone having a heat of evaporation ranging from 21,000 to 27,000 cal/mole and a parameter, as a measure for the solubility, ranging from 8 to 9 cal1/2 c... | 10/17/2000 |
| 6126948 | Stable oil-in-water emulsion, process for its manufacture and its use in the cosmetic and dermatological fields A fine and stable emulsion of an oily phase in an aqueous phase containing ionic polymer particles, the oil globules of the emulsion having a mean size of at most 500 nm, a process for the stabilization of fluid emulsions, a process for the preparation of... | 10/03/2000 |
| 6126929 | Cosmetic composition comprising a mixture of polymer particles capable of being film-formed and particles not capable of being film-formed The present invention is directed to cosmetic or dermatological compositions comprising, in a cosmetically acceptable aqueous medium, as an agent for coating keratin fibres, from 15 to 60% by weight of solids of a film-forming mixture comprising: (A) at l... | 10/03/2000 |
| 6123956 | Methods for universally distributing therapeutic agents to the brain A method for universally distributing a therapeutic agent, in an encapsulated form, to the brain of a subject using intrathecal administration, excluding the lumbar region, is described. Methods for treating stroke and/or Traumatic Brain Injury (TBI) are ... | 09/26/2000 |
| 6120807 | Prolonged release of GM-CSF Formulations for controlled, prolonged release of GM-CSF have been developed. These are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers... | 09/19/2000 |
| 6120759 | Anhydrous skin cleansing agent and use thereof An anhydrous skin cleansing agent comprising a surfactant, organic solvent and water-insoluble abrasive as active components and a water-swellable organic polymer as a soil carrier and abrasive.... | 09/19/2000 |
| 6120805 | Microspheres, process for their preparation and their use Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepa... | 09/19/2000 |
| 6117949 | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties A water soluble biodegradable ABA- or BAB-type triblock polymer is disclosed that is made up of a major amount of a hydrophobic polymer made of a poly(lactide-co-glycolide) copolymer or poly(lactide) polymer as the A-blocks and a minor amount of a hydroph... | 09/12/2000 |
