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| Number | Title | Issue Date |
| 7588780 | Embolization Embolic polymer particles are described. For example, the particles include pores such that the predominant size of pores near the center of the particles is greater than the predominant size of pores adjacent to periphery of the particle ... | 09/15/2009 |
| 7585521 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are de... | 09/08/2009 |
| 7442385 | Chemoembolisation A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin. | 10/28/2008 |
| 7419685 | Process for producing solid dosage forms Solid dosage forms containing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives, wherein a physiologically tolerated, water-swellable graft copolymer or a mixture of graft copolymers is employed as polymeric b... | 09/02/2008 |
| 7413752 | Composite hydrogel drug delivery systems Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. Th... | 08/19/2008 |
| 7387994 | Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculat... | 06/17/2008 |
| 7374778 | Enhanced transport using membrane disruptive agents Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enh... | 05/20/2008 |
| 7371781 | Tumor environment-induced ligand-expressing nanocarrier system Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted... | 05/13/2008 |
| 7371738 | Method of transdermal drug delivery using hyaluronic acid nanoparticles The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other hydrophilic or hydrophobic molecules, the composition of hyaluronic acid and ... | 05/13/2008 |
| 7364748 | Controlled morphologies in polymer drug for release of drugs from polymer films The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase. ... | 04/29/2008 |
| 7357339 | Wet pulverizing of polysaccharides Polysaccharide is wet pulverized by ejecting a liquid dispersion of polysaccharide from a pair of nozzles under a high pressure of 70 to 250 MPa to form a pair of jets so that the jets collide against each other. The nozzles are oriented to define a collision angle ... | 04/15/2008 |
| 7357948 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are de... | 04/15/2008 |
| 7354603 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are de... | 04/08/2008 |
| 7354602 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are de... | 04/08/2008 |
| 7351430 | Shape-retentive hydrogel particle aggregates and their uses The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wid... | 04/01/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7348031 | Method for preparing colloidal particles in the form of nanocapsules The invention relates to a process for the preparation of dispersible colloidal systems in the form of nanocapsules whose wall consists of a polymer obtained by the polycondensation of two monomers, α and β, and whose core consists of a substance B, characterized ... | 03/25/2008 |
| 7344705 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarb... | 03/18/2008 |
| 7338657 | Injectable microspheres for tissue construction The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tiss... | 03/04/2008 |
| 7335391 | Method for coating implantable devices A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. ... | 02/26/2008 |
| 7335379 | Transdermal pharmaceutical formulation for minimizing skin residues This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically act... | 02/26/2008 |
| 7329413 | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof Coatings for implantable medical devices, and methods for fabricating thereof, are provided. The coatings include a first polymer layer and a second polymer layer, where the second polymer has a higher degree of hydration than the first polymer. ... | 02/12/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7323190 | Cell delivery system comprising a fibrous matrix and cells Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and ... | 01/29/2008 |
| 7318932 | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same A polymer coating for medical devices based on a derivatized poly(ethylene-co-vinyl alcohol) is disclosed. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include poly(ethylene-co-vinyl a... | 01/15/2008 |
| 7311980 | Polyactive/polylactic acid coatings for an implantable device A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided. ... | 12/25/2007 |
| 7309757 | Polymers for the delivery of bioactive agents and methods of their preparation Provided is a poly(amino ester) having a polymer backbone comprising at least one secondary amine linkage and at least one tertiary amine linkage in the polymer backbone. Poly(amino ester)s are prepared via the Michael addition of a bis(acrylate ester)monomer to a d... | 12/18/2007 |
| 7304122 | Elastomeric functional biodegradable copolyester amides and copolyester urethanes The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are u... | 12/04/2007 |
| 7300671 | Method and apparatus for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mix... | 11/27/2007 |
| 7299587 | Method and apparatus for controlling pests A method of controlling pests, such as insects, by trapping and/or killing them wherein at least a part of a pest to be trapped or killed is exposed a composition comprising particles containing or consisting of at least one magnetic material. ... | 11/27/2007 |
| 7291348 | Compositions and methods for biodegradable microspheres as carriers of bioactive substances A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to n... | 11/06/2007 |
| 7288319 | Forming a chemically cross-linked particle of a desired shape and diameter Chemically cross-linked polymeric particles are formed using mechanical rather than chemical processes, facilitating production of small-diameter particles in a manner largely independent of the viscosity or density of the polymer. For example, an uncross-linked res... | 10/30/2007 |
| 7288267 | Bioadhesive nanoparticulate compositions having cationic surface stabilizers Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biolog... | 10/30/2007 |
| 7285289 | Nanoparticle vaccines The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also displa... | 10/23/2007 |
| 7282338 | Cell migration assay The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers. ... | 10/16/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7282220 | Genipin-crosslinked gelatin microspheres as drug carrier A pharmaceutical microsphere comprises a bioactive agent and a biological carrier that encapsulates the bioactive agent, wherein the biological carrier is crosslinked with a crosslinking agent. ... | 10/16/2007 |
| 7282194 | Nanoparticles for protein drug delivery The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery. ... | 10/16/2007 |
| 7282195 | Flavored sealants A single-component composition for repairing, protecting or sealing teeth comprising a polymerizable resin, a flavoring agent, wherein the flavoring agent is a non-oil containing natural flavoring agent, or an artificial flavoring agent, an ultraviolet light absorbe... | 10/16/2007 |
| 7282219 | Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability A powdery preparation for transmucosal administration comprising a medicine of high molecular weight, a cationic polymer and, as needed, a viscous polymer, further comprising an effective amount of a basic amino acid. The powdery preparation for transmucosal adminis... | 10/16/2007 |